Author results

6NYT
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MUNC13-1 C2B-DOMAIN, CALCIUM BOUND
Descriptor:Protein unc-13 homolog A, CALCIUM ION, CHLORIDE ION, ...
Authors:Tomchick, D.R., Rizo, J., Machius, M., Lu, J.
Deposit date:2019-02-12
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.369 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
6NYC
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MUNC13-1 C2B-DOMAIN, CALCIUM FREE
Descriptor:Munc13-1, CHLORIDE ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Tomchick, D.R., Rizo, J., Machius, M., Lu, J.
Deposit date:2019-02-11
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
6MET
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-07
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6MEO
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-06
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6AHF
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CRYOEM RECONSTRUCTION OF HSP104 N728A HEXAMER
Descriptor:Heat shock protein 104, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Zhang, X., Zhang, L., Zhang, S.
Deposit date:2018-08-17
Release date:2019-02-13
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (6.78 Å)
Cite:Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity.
J. Biol. Chem., 2019
6E3S
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST PT2385
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3T
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST T1001
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3U
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH AGONIST M1001
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione
Authors:Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6DAD
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1.65 ANGSTROM CRYSTAL STRUCTURE OF THE N97I CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAE
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2.0 ANGSTROM CRYSTAL STRUCTURE OF THE D95V CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Lu, J., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAF
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2.4 ANGSTROM CRYSTAL STRUCTURE OF THE F141L CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAH
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2.5 ANGSTROM CRYSTAL STRUCTURE OF THE N97S CAM MUTANT
Descriptor:Calmodulin-1, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6GDK
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CALCIUM BOUND FORM OF HUMAN CALMODULIN MUTANT F141L
Descriptor:Calmodulin-1, CALCIUM ION
Authors:Grachov, O., Holt, C., Overgaard, M.T., Wimmer, R.
Deposit date:2018-04-23
Release date:2018-10-17
Last modified:2018-11-14
Method:SOLUTION NMR
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6GDL
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CALMODULIN MUTANT - F141L APO-FORM UNSTRUCTURED C-DOMAIN
Descriptor:Calmodulin-1
Authors:Holt, C., Overgaard, M.T., Wimmer, R.
Deposit date:2018-04-23
Release date:2018-10-17
Last modified:2018-11-14
Method:SOLUTION NMR
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CYB
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PDE2 IN COMPLEX WITH COMPOUND 7
Descriptor:cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Lu, J.
Deposit date:2018-04-05
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ACS Med Chem Lett, 9, 2018
6CYC
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PDE2 IN COMPLEX WITH COMPOUND 5
Descriptor:cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Lu, J.
Deposit date:2018-04-05
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ACS Med Chem Lett, 9, 2018
6CYD
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PDE2 IN COMPLEX WITH COMPOUND 7
Descriptor:cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Lu, J.
Deposit date:2018-04-05
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ACS Med Chem Lett, 9, 2018
6CFH
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SWGMMGMLASQ SEGMENT FROM THE LOW COMPLEXITY DOMAIN OF TDP-43
Descriptor:SWGMMGMLASQ
Authors:Guenther, E.L., Rodriguez, J.A., Sawaya, M.R., Eisenberg, D.S.
Deposit date:2018-02-15
Release date:2018-05-23
Last modified:2018-06-13
Method:ELECTRON CRYSTALLOGRAPHY (1.5 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CF4
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SEGMENT NFGTFS, WITH FAMILIAL MUTATION A315T AND PHOSPHORYLATED THREONINE, FROM THE LOW COMPLEXITY DOMAIN OF TDP-43, RESIDUES 312-317
Descriptor:NFGTFS
Authors:Guenther, E.L., Cao, Q., Boyer, D.R., Sawaya, M.R., Eisenberg, D.S.
Deposit date:2018-02-13
Release date:2018-05-23
Last modified:2018-06-13
Method:ELECTRON CRYSTALLOGRAPHY (0.75 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CEW
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SEGMENT AMMAAA FROM THE LOW COMPLEXITY DOMAIN OF TDP-43, RESIDUES 321-326
Descriptor:AMMAAA
Authors:Guenther, E.L., Cao, Q., Lu, J., Sawaya, M.R., Eisenberg, D.S.
Deposit date:2018-02-12
Release date:2018-04-18
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CB9
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SEGMENT AALQSS FROM THE LOW COMPLEXITY DOMAIN OF TDP-43, RESIDUES 328-333
Descriptor:AALQSS
Authors:Guenther, E.L., Cao, Q., Lu, J., Sawaya, M.R., Eisenberg, D.S.
Deposit date:2018-02-02
Release date:2018-04-18
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
5Z6Q
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CRYSTAL STRUCTURE OF AAA OF SPASTIN
Descriptor:Spastin, CHLORIDE ION
Authors:Lin, Z., Wang, C., Shen, Y.
Deposit date:2018-01-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The AAA protein spastin possesses two levels of basal ATPase activity
FEBS Lett., 592, 2018
6C68
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MHC-INDEPENDENT T CELL RECEPTOR A11
Descriptor:T-cell receptor alpha chain, T-cell receptor beta chain
Authors:Lu, J., Van Laethem, F., Saba, I., Chu, J., Bhattacharya, A., Love, N.C., Tikhonova, A., Radaev, S., Sun, X., Ko, A., Arnon, T., Shifrut, E., Friedman, N., Weng, N., Singer, A., Sun, P.D.
Deposit date:2018-01-18
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:MHC-independent t cell receptor A11
To Be Published
6C61
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MHC-INDEPENDENT T-CELL RECEPTOR B12A
Descriptor:T-cell receptor alpha chain, T-cell receptor beta chain
Authors:Lu, J., Sun, P.
Deposit date:2018-01-17
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:MHC-independent T-cell receptor B12A
To Be Published
6BP1
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CRYSTAL STRUCTURE OF HUMAN KRAS A59G MUTANT IN COMPLEX WITH GCP
Descriptor:GTPase KRas, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Bera, A.K., Lu, J., Westover, K.D.
Deposit date:2017-11-21
Release date:2018-01-24
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
Biochemistry, 57, 2018