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4XEY
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BU of 4xey by Molmil
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
Descriptor: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase ABL1
Authors:Lorenz, S, Deng, P, Kuriyan, J.
Deposit date:2014-12-25
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.891 Å)
Cite:Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
Biochem.J., 468, 2015
2VZG
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BU of 2vzg by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD2 motif
Descriptor: 1,2-ETHANEDIOL, Alpha-parvin, Paxillin, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-08-01
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.
Structure, 16, 2008
2VZD
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BU of 2vzd by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha parvin in complex with paxillin LD1 motif
Descriptor: 1,2-ETHANEDIOL, ALPHA-PARVIN, GLYCEROL, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-07-31
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of the Interactions between Paxillin Ld Motifs and Alpha-Parvin
Structure, 16, 2008
2VZI
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BU of 2vzi by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD4 motif
Descriptor: 1,2-ETHANEDIOL, Alpha-parvin, Paxillin,Paxillin, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-08-01
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.
Structure, 16, 2008
2VZC
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BU of 2vzc by Molmil
Crystal structure of the C-terminal calponin homology domain of alpha parvin
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K.
Deposit date:2008-07-31
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structural Analysis of the Interactions between Paxillin Ld Motifs and Alpha-Parvin
Structure, 16, 2008
6XZ1
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BU of 6xz1 by Molmil
Conjugate of the HECT domain of HUWE1 with ubiquitin
Descriptor: HECT, UBA and WWE domain containing 1, isoform CRA_a, ...
Authors:Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S.
Deposit date:2020-01-31
Release date:2021-08-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
8Q0N
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BU of 8q0n by Molmil
HACE1 in complex with RAC1 Q61L
Descriptor: E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ...
Authors:Wolter, M, Duering, J, Dienemann, C, Lorenz, S.
Deposit date:2023-07-28
Release date:2024-01-10
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
8PWL
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BU of 8pwl by Molmil
Cryo-EM structure of a full-length HACE1 dimer
Descriptor: E3 ubiquitin-protein ligase HACE1
Authors:Duering, J, Wolter, M, Dienemann, C, Lorenz, S.
Deposit date:2023-07-20
Release date:2024-01-10
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.73 Å)
Cite:Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
353D
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BU of 353d by Molmil
CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE
Descriptor: RNA (5'-R(*AP*UP*CP*CP*CP*CP*CP*GP*UP*GP*CP*C)-3'), RNA (5'-R(*GP*GP*UP*GP*CP*GP*GP*GP*GP*GP*AP*U)-3')
Authors:Betzel, C, Lorenz, S, Furste, J.P, Bald, R, Zhang, M, Schneider, T.R, Wilson, K.S, Erdmann, V.A.
Deposit date:1997-09-29
Release date:1997-11-10
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of domain A of Thermus flavus 5S rRNA and the contribution of water molecules to its structure.
FEBS Lett., 351, 1994
6QH3
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BU of 6qh3 by Molmil
Catalytic domain of the human ubiquitin-conjugating enzyme UBE2S C118M
Descriptor: 1,2-ETHANEDIOL, Ubiquitin-conjugating enzyme E2 S
Authors:Liess, A.K.L, Lorenz, S.
Deposit date:2019-01-15
Release date:2019-07-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Structure, 27, 2019
6QHK
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BU of 6qhk by Molmil
PAO-linked dimer of the catalytic domain of the human ubiquitin-conjugating enzyme UBE2S
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Phenylarsine oxide, ...
Authors:Liess, A.K.L, Lorenz, S.
Deposit date:2019-01-16
Release date:2019-07-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Structure, 27, 2019
1JXB
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BU of 1jxb by Molmil
I53A, a point mutant of the cysteine-free variant of E. coli Rnase HI
Descriptor: Ribonuclease HI
Authors:Spudich, G, Lorenz, S, Marqusee, S.
Deposit date:2001-09-06
Release date:2002-03-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state.
Protein Sci., 11, 2002
6S98
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BU of 6s98 by Molmil
Crystal structure of the catalytic domain of UBE2S WT.
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, SODIUM ION, ...
Authors:Liess, A.K.L, Lorenz, S.
Deposit date:2019-07-11
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Sci.Signal., 13, 2020
6S96
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BU of 6s96 by Molmil
Crystal structure of the catalytic domain of UBE2S C118A.
Descriptor: FORMIC ACID, SODIUM ION, Ubiquitin-conjugating enzyme E2 S
Authors:Liess, A.K.L, Lorenz, S.
Deposit date:2019-07-11
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Sci.Signal., 13, 2020
6TGK
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BU of 6tgk by Molmil
Domain swapped E6AP C-lobe dimer
Descriptor: ACETATE ION, CALCIUM ION, Ubiquitin-protein ligase E3A
Authors:Ries, L.K, Feiler, C, Lowe, L.D, Liess, A.K.L, Lorenz, S.
Deposit date:2019-11-16
Release date:2020-02-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.
Protein Sci., 29, 2020
7AZW
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BU of 7azw by Molmil
Crystal structure of the MIZ1-BTB-domain
Descriptor: GLYCEROL, Zinc finger and BTB domain-containing protein 17 isoform X1
Authors:Orth, B, Sander, B, Diederichs, K, Lorenz, S.
Deposit date:2020-11-17
Release date:2021-06-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
Structure, 29, 2021
7AZX
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BU of 7azx by Molmil
Crystal structure of the MIZ1-BTB-domain in complex with a HUWE1-derived peptide
Descriptor: E3 ubiquitin-protein ligase HUWE1, Zinc finger and BTB domain-containing protein 17 isoform X1
Authors:Orth, B, Sander, B, Diederichs, K, Lorenz, S.
Deposit date:2020-11-17
Release date:2021-06-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
Structure, 29, 2021
7AHF
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BU of 7ahf by Molmil
Dimeric structure of the catalytic domain of the human ubiquitin-conjugating enzyme UBE2S L114E varaiant
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Ubiquitin-conjugating enzyme E2 S
Authors:Liess, A.K.L, Feiler, C.G, Lorenz, S.
Deposit date:2020-09-24
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural analyses of the ubiquitin-conjugating enzyme UBE2S in different crystal forms
To Be Published
361D
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BU of 361d by Molmil
CRYSTAL STRUCTURE OF DOMAIN E OF THERMUS FLAVUS 5S RRNA: A HELICAL RNA-STRUCTURE INCLUDING A TETRALOOP
Descriptor: RNA (5'-R(*CP*UP*GP*GP*GP*CP*GP*GP*GP*CP*GP*AP*CP*CP*GP*CP*C P*UP*GP*G)-3')
Authors:Perbandt, M, Nolte, A, Lorenz, S, Erdmann, V.A, Betzel, C.
Deposit date:1997-11-10
Release date:1998-07-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of domain E of Thermus flavus 5S rRNA: a helical RNA structure including a hairpin loop.
FEBS Lett., 429, 1998
5BNB
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BU of 5bnb by Molmil
Crystal structure of a Ube2S-ubiquitin conjugate
Descriptor: Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 S
Authors:Lorenz, S.G, Feiler, C.G, Kuriyan, J.
Deposit date:2015-05-25
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal Structure of a Ube2S-Ubiquitin Conjugate.
Plos One, 11, 2016
5LP8
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BU of 5lp8 by Molmil
Crystal structure of an asymmetric dimer of the ubiquitin ligase HUWE1
Descriptor: E3 ubiquitin-protein ligase HUWE1
Authors:Sander, B, Lorenz, S.G.
Deposit date:2016-08-12
Release date:2017-02-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conformational switch regulates the ubiquitin ligase HUWE1.
Elife, 6, 2017
6ELJ
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BU of 6elj by Molmil
FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
Descriptor: fAB heavy chain, fAB light chain
Authors:Benz, J, Weigand, S, Dengl, S, Schlothauer, T, Auer, J, Ehler, A, Kettenberger, H, Lorenz, S, Hirschheydt, T, Georges, G.
Deposit date:2017-09-29
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELE
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BU of 6ele by Molmil
FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
Descriptor: 1,2-ETHANEDIOL, SODIUM ION, fAB heavy chain, ...
Authors:Benz, J, Weigand, S, Dengl, S, Schlothauer, T, Auer, J, Ehler, A, Kettenberger, H, Lorenz, S, Hirschheydt, T, Georges, G.
Deposit date:2017-09-28
Release date:2017-11-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELL
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BU of 6ell by Molmil
FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
Descriptor: fAB heavy chain, fAB light chain
Authors:Benz, J, Weigand, S, Dengl, S, Schlothauer, T, Auer, J, Ehler, A, Kettenberger, H, Lorenz, S, Hirschheydt, T, Georges, G.
Deposit date:2017-09-29
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6EMJ
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BU of 6emj by Molmil
FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
Descriptor: SODIUM ION, fAB heavy chain, fAb light chain
Authors:Benz, J, Weigand, S, Dengl, S, Schlothauer, T, Auer, J, Ehler, A, Kettenberger, H, Lorenz, S, Hirschheydt, T, Georges, G.
Deposit date:2017-10-02
Release date:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published

 

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