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5JKV
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL
Descriptor:Aromatase, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ...
Authors:Ghosh, D., Lo, J., Egbuta, C.
Deposit date:2016-04-26
Release date:2017-04-26
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Testosterone complex and non-steroidal ligands of human aromatase.
J. Steroid Biochem. Mol. Biol., 2018
5JKW
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) COMPLEXED WITH TESTOSTERONE
Descriptor:Aromatase, PROTOPORPHYRIN IX CONTAINING FE, TESTOSTERONE
Authors:Ghosh, D., Egbuta, C., Lo, J.
Deposit date:2016-04-26
Release date:2017-04-26
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Testosterone complex and non-steroidal ligands of human aromatase.
J. Steroid Biochem. Mol. Biol., 2018
5JL6
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #2
Descriptor:Aromatase, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE
Authors:Ghosh, D., Lo, J., Egbuta, C.
Deposit date:2016-04-26
Release date:2017-04-26
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Testosterone complex and non-steroidal ligands of human aromatase.
J. Steroid Biochem. Mol. Biol., 2018
5JL7
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #3
Descriptor:Aromatase, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE
Authors:Ghosh, D., Lo, J., Egbuta, C.
Deposit date:2016-04-26
Release date:2017-04-26
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Testosterone complex and non-steroidal ligands of human aromatase.
J. Steroid Biochem. Mol. Biol., 2018
5JL9
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #4
Descriptor:Aromatase, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE
Authors:Ghosh, D., Lo, J., Egbuta, C.
Deposit date:2016-04-26
Release date:2017-04-26
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Testosterone complex and non-steroidal ligands of human aromatase.
J. Steroid Biochem. Mol. Biol., 2018
4KQ8
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STRUCTURE OF RECOMBINANT HUMAN CYTOCHROME P450 AROMATASE
Descriptor:Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ...
Authors:Ghosh, D., Di Nardo, G., Griswold, J.
Deposit date:2013-05-14
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural basis for the functional roles of critical residues in human cytochrome p450 aromatase.
Biochemistry, 52, 2013
2FLU
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CRYSTAL STRUCTURE OF THE KELCH-NEH2 COMPLEX
Descriptor:Kelch-like ECH-associated protein 1, Nrf2
Authors:Li, X., Lo, J., Beamer, L., Hannink, M.
Deposit date:2006-01-06
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006
3S79
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HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) REFINED AT 2.75 ANGSTROM
Descriptor:Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ...
Authors:Ghosh, D.
Deposit date:2011-05-26
Release date:2012-06-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Novel aromatase inhibitors by structure-guided design.
J.Med.Chem., 55, 2012
3S7S
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CRYSTAL STRUCTURE OF HUMAN PLACENTAL AROMATASE COMPLEXED WITH BREAST CANCER DRUG EXEMESTANE
Descriptor:Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (8alpha,10alpha,13alpha)-6-methylideneandrosta-1,4-diene-3,17-dione
Authors:Ghosh, D.
Deposit date:2011-05-26
Release date:2012-06-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Novel aromatase inhibitors by structure-guided design.
J.Med.Chem., 55, 2012
4GL5
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STRUCTURE OF HUMAN PLACENTAL AROMATASE COMPLEXED WITH DESIGNED INHIBITOR HDDG029 (COMPOUND 4)
Descriptor:Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (6alpha,8alpha)-6-(but-2-yn-1-yloxy)androsta-1,4-diene-3,17-dione
Authors:Ghosh, D.
Deposit date:2012-08-13
Release date:2012-09-12
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Novel aromatase inhibitors by structure-guided design.
J.Med.Chem., 55, 2012
4GL7
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STRUCTURE OF HUMAN PLACENTAL AROMATASE COMPLEXED WITH DESIGNED INHIBITOR HDDG046 (COMPOUND 5)
Descriptor:Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (6alpha,8alpha)-6-(pent-2-yn-1-yloxy)androsta-1,4-diene-3,17-dione
Authors:Ghosh, D.
Deposit date:2012-08-13
Release date:2012-09-12
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Novel aromatase inhibitors by structure-guided design.
J.Med.Chem., 55, 2012
2N59
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SOLUTION STRUCTURE OF R. PALUSTRIS CSGH
Descriptor:Putative uncharacterized protein CsgH
Authors:Hawthorne, W.J., Taylor, J.D., Escalera-Maurer, A., Lambert, S., Koch, M., Scull, N., Sefer, L., Xu, Y., Matthews, S.J.
Deposit date:2015-07-13
Release date:2016-05-11
Method:SOLUTION NMR
Cite:Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
Sci Rep, 6, 2016
4KJU
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CRYSTAL STRUCTURE OF XIAP-BIR2 WITH A BOUND BENZODIAZEPINONE INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase XIAP, ZINC ION, N-{(3S)-5-(4-aminobenzoyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N~2~-methyl-L-alaninamide
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-05-03
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain.
J.Med.Chem., 56, 2013
4KJV
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CRYSTAL STRUCTURE OF XIAP-BIR2 WITH A BOUND SPIROCYCLIC BENZOXAZEPINONE INHIBITOR.
Descriptor:E3 ubiquitin-protein ligase XIAP, ZINC ION, 6-methoxy-5-({(3S)-3-[(N-methyl-L-alanyl)amino]-4-oxo-2',3,3',4,5',6'-hexahydro-5H-spiro[1,5-benzoxazepine-2,4'-pyran]-5-yl}methyl)naphthalene-2-carboxylic acid
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-05-03
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain.
J.Med.Chem., 56, 2013