Author results

1Q1M
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A HIGHLY EFFICIENT APPROACH TO A SELECTIVE AND CELL ACTIVE PTP1B INHIBITORS
分子名称:Protein-tyrosine phosphatase, non-receptor type 1, 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID
著者Liu, G., Xin, Z., Pei, Z., Hajduk, P.J., Abad-Zapatero, C., Hutchins, C.W., Zhao, H., Lubben, T.H., Ballaron, S.J., Haasch, D.L., Kaszubska, W., Rondinone, C.M., Trevillyan, J.M., Jirousek, M.R.
登録日2003-07-22
公開日2003-09-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
J.Med.Chem., 46, 2003
2JWY
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SOLUTION NMR STRUCTURE OF UNCHARACTERIZED LIPOPROTEIN YAJI FROM ESCHERICHIA COLI. NORTHEAST STRUCTURAL GENOMICS TARGET ER540
分子名称:Uncharacterized lipoprotein yajI
著者Liu, G., Xiao, R., Chen, C., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2007-10-31
公開日2007-11-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of uncharacterized lipoprotein yajI from Escherichia coli.
To be Published
5HLG
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STRUCTURE OF REDUCED ABFR BOUND TO DNA
分子名称:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
著者Liu, G., Liu, X., Gan, J., Yang, C.G.
登録日2016-01-15
公開日2017-01-25
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLH
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CRYSTAL STRUCTURE OF THE OVEROXIDIZED ABFR BOUND TO DNA
分子名称:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
著者Liu, G., Liu, X., Gan, J., Yang, C.-G.
登録日2016-01-15
公開日2017-01-25
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLI
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STRUCTURE OF DISULFIDE FORMED ABFR
分子名称:MarR family transcriptional regulator, COPPER (II) ION, CHLORIDE ION
著者Liu, G., Liu, X., Gan, J., Yang, C.-G.
登録日2016-01-15
公開日2017-01-25
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
1ONY
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 17
分子名称:Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID
著者Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
登録日2003-03-02
公開日2003-05-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
1ONZ
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 8B
分子名称:Protein-tyrosine phosphatase, non-receptor type 1, 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
著者Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
登録日2003-03-02
公開日2003-05-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
2JXT
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SOLUTION STRUCTURE OF 50S RIBOSOMAL PROTEIN LX FROM METHANOBACTERIUM THERMOAUTOTROPHICUM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR80
分子名称:50S ribosomal protein LX
著者Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2007-11-29
公開日2007-12-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of 50S ribosomal protein LX from Methanobacterium thermoautotrophicum.
To be Published
2KCP
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SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E; FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
分子名称:30S ribosomal protein S8e
著者Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2008-12-24
公開日2009-07-14
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET
To be Published
2KCV
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SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C
分子名称:Tetratricopeptide repeat domain protein
著者Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2008-12-29
公開日2009-01-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c
To be Published
2KCY
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SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
分子名称:30S ribosomal protein S8e
著者Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B.C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2008-12-30
公開日2009-01-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
To be Published
2KK0
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SOLUTION STRUCTURE OF DEAD RINGER-LIKE PROTEIN 1 (AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A) FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR4394C
分子名称:AT-rich interactive domain-containing protein 3A
著者Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2009-06-14
公開日2009-07-14
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target.
Proteins, 78, 2010
2KK1
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SOLUTION STRUCTURE OF C-TERMINAL DOMAIN OF TYROSINE-PROTEIN KINASE ABL2 FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR5537A
分子名称:Tyrosine-protein kinase ABL2
著者Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2009-06-14
公開日2009-08-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.
Proteins, 78, 2010
2HFI
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SOLUTION NMR STRUCTURE OF PROTEIN YPPE FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR213
分子名称:Hypothetical protein yppE
著者Liu, G., Singarapu, K.K., Parish, D., Eletsky, A., Xu, D., Sukumaran, D., Ho, C.K., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
登録日2006-06-23
公開日2006-07-25
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of hypothetical protein yppE: Northeast Structural Genomics Consortium Target SR213
TO BE PUBLISHED
2HG7
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SOLUTION NMR STRUCTURE OF PHAGE-LIKE ELEMENT PBSX PROTEIN XKDW, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR355
分子名称:Phage-like element PBSX protein xkdW
著者Liu, G., Parish, D., Xu, D., Atreya, H., Sukumaran, D., Ho, C.K., Jiang, M., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
登録日2006-06-26
公開日2006-08-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of Phage-like element PBSX protein xkdW, Northeast Structural Genomics Consortium Target SR355
TO BE PUBLISHED
2HI6
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SOLUTION NMR STRUCTURE OF UPF0107 PROTEIN AF_0055, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET GR101
分子名称:UPF0107 protein AF0055
著者Liu, G., Atreya, H., Xu, D., Sukumaran, D.K., Chen, C.X., Janjua, H., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
登録日2006-06-29
公開日2006-08-29
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of UPF0107 protein AF_0055, Northeast Structural Genomics Consortium Target GR101 (CASP Target)
To be Published
2KCL
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SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C
分子名称:Tetratricopeptide repeat domain protein
著者Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2008-12-22
公開日2009-01-06
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution NMR structure of tetratricopeptide repeat domain protein SrU_0103 from Salinibacter ruber, Northeast Structural Genomics Consortium (NESG) Target SrR115C
To be Published
2K07
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SOLUTION NMR STRUCTURE OF HUMAN E2-LIKE UBIQUITIN-FOLD MODIFIER CONJUGATING ENZYME 1 (UFC1). NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR41
分子名称:Ufm1-conjugating enzyme 1
著者Liu, G., Eletsky, A., Atreya, H.S., Aramini, J.M., Xiao, R., Acton, T., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
登録日2008-01-25
公開日2008-02-19
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
J.STRUCT.FUNCT.GENOM., 10, 2009
2MBL
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33
分子名称:Top7 Fold Protein Top7m13
著者Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2013-08-02
公開日2013-11-13
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
2MBM
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33
分子名称:Top7 Fold Protein Top7m13
著者Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2013-08-02
公開日2013-11-13
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
2MTL
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FR55, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR109
分子名称:De novo designed protein FR55 OR109
著者Liu, G., Koga, N., Koga, R., Xiao, R., Hamilton, K., Ciccosanti, C., Sahdev, S., Kohan, E., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2014-08-19
公開日2014-10-29
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109
To be Published
2N2T
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN (FDA_60), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR303
分子名称:OR303
著者Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2015-05-14
公開日2015-09-16
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303
To be Published
2N2U
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FERREDOXIN FOLD PROTEIN SFR3, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR358
分子名称:OR358
著者Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2015-05-14
公開日2015-09-16
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358
To be Published
2N3Z
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN, ROSSMANN2X2 FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR446
分子名称:OR446
著者Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2015-06-15
公開日2015-09-16
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446
To be Published
2N41
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN TOP7NNSTYCC, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR34
分子名称:OR34
著者Liu, G., Chan, K., Basanta, B., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2015-06-16
公開日2016-03-02
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of DE NOVO DESIGNED PROTEIN Top7NNSTYCC, Northeast Structural Genomics Consortium (NESG) Target OR34
To be Published