Author results

4M9V
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ZFP57 MUTANT (E182Q) IN COMPLEX WITH 5-CARBOXYLCYTOSINE DNA
分子名称:DNA (5'-D(*TP*AP*TP*TP*GP*CP*(5CM)P*GP*CP*AP*G)-3'), DNA (5'-D(*AP*CP*TP*GP*(1CC)P*GP*GP*CP*AP*AP*T)-3'), Zinc finger protein 57, ...
著者Liu, Y., Olanrewaju, Y.O., Zhang, X., Cheng, X.
登録日2013-08-15
公開日2013-11-27
最終更新日2014-01-22
実験手法X-RAY DIFFRACTION (0.969 Å)
主引用文献DNA recognition of 5-carboxylcytosine by a zfp57 mutant at an atomic resolution of 0.97 angstrom.
Biochemistry, 52, 2013
4GZN
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MOUSE ZFP57 ZINC FINGERS IN COMPLEX WITH METHYLATED DNA
分子名称:DNA (5'-D(*TP*AP*TP*TP*GP*CP*(5CM)P*GP*CP*AP*G)-3'), DNA (5'-D(*AP*CP*TP*GP*(5CM)P*GP*GP*CP*AP*AP*T)-3'), Zinc finger protein 57, ...
著者Liu, Y., Zhang, X., Cheng, X.
登録日2012-09-06
公開日2012-10-17
最終更新日2012-11-21
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence.
Genes Dev., 26, 2012
4TXR
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CRYSTAL STRUCTURE OF LIP5 N-TERMINAL DOMAIN COMPLEXED WITH CHMP1B MIM AND CHMP5 MIM
分子名称:Charged multivesicular body protein 1b, Vacuolar protein sorting-associated protein VTA1 homolog, Charged multivesicular body protein 5, ...
著者Vild, C.J., Xu, Z.
登録日2014-07-04
公開日2015-02-11
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献A Novel Mechanism of Regulating the ATPase VPS4 by Its Cofactor LIP5 and the Endosomal Sorting Complex Required for Transport (ESCRT)-III Protein CHMP5.
J.Biol.Chem., 290, 2015
4L1T
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TRANSTHYRETIN IN COMPLEX WITH (E)-3-(DIMETHYLAMINO)-5-(4-HYDROXY-3,5-DIMETHYLSTYRYL)BENZOIC ACID
分子名称:Transthyretin, 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid
著者Connelly, S., Wilson, I.A.
登録日2013-06-03
公開日2013-10-02
最終更新日2014-08-20
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn.
Biopolymers, 101, 2014
5EQ0
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX8 IN COMPLEX WITH INHIBITOR UNC3866
分子名称:Chromobox protein homolog 8, unc3866, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-11-12
公開日2015-12-23
最終更新日2016-02-24
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat.Chem.Biol., 12, 2016
5J41
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GLUTATHIONE S-TRANSFERASE BOUND WITH HYDROLYZED PIPERLONGUMINE
分子名称:Glutathione S-transferase P, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ...
著者Harshbarger, W., Gondi, S., Ficarro, S., Hunter, J., Udayakumar, D., Gurbani, D., Marto, J., Westover, K.
登録日2016-03-31
公開日2016-11-30
最終更新日2017-01-18
実験手法X-RAY DIFFRACTION (1.190354 Å)
主引用文献Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.
J. Biol. Chem., 292, 2017
3A9B
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CCCEL6C, A GLYCOSIDE HYDROLASE FAMILY 6 ENZYME, COMPLEXED WITH CELLOBIOSE
分子名称:Cellobiohydrolase, MAGNESIUM ION, BETA-D-GLUCOSE, ...
著者Liu, Y., Yoshida, M., Kurakata, Y., Miyazaki, T., Nishikawa, A., Tonozuka, T.
登録日2009-10-22
公開日2009-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of a glycoside hydrolase family 6 enzyme, CcCel6C, a cellulase constitutively produced by Coprinopsis cinerea
Febs J., 277, 2010
3MI2
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CRYSTAL STRUCTURE OF HUMAN OROTIDINE-5'-MONOPHOSPHATE DECARBOXYLASE COMPLEXED WITH PYRAZOFURIN MONOPHOSPHATE
分子名称:Uridine 5'-monophosphate synthase, (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol
著者Liu, Y., To, T., Kotra, L.P., Pai, E.F.
登録日2010-04-09
公開日2010-05-26
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.
Bioorg.Med.Chem., 18, 2010
4D0Q
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HYALURONAN BINDING MODULE OF THE STREPTOCOCCAL PNEUMONIAE HYALURONATE LYASE
分子名称:HYALURONATE LYASE, 1,2-ETHANEDIOL
著者Suits, M.D.L., Pluvinage, B., Law, A., Liu, Y., Palma, A.S., Chai, W., Feizi, T., Boraston, A.B.
登録日2014-04-29
公開日2014-08-06
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Conformational Analysis of the Streptococcus Pneumoniae Hyaluronate Lyase and Characterization of its Hyaluronan-Specific Carbohydrate-Binding Module.
J.Biol.Chem., 289, 2014
6DUB
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CRYSTAL STRUCTURE OF A METHYLTRANSFERASE
分子名称:Alpha N-terminal protein methyltransferase 1B, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-06-20
公開日2018-07-25
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
4HJS
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KINETIC STABILIZATION OF TRANSTHYRETIN THROUGH COVALENT MODIFICATION OF K15 BY (E)-N-(4-(4-HYDROXY-3,5-DIMETHYLSTYRYL)ETHANESULFONAMIDE
分子名称:Transthyretin, N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide
著者Connelly, S., Wilson, I.A.
登録日2012-10-14
公開日2013-12-04
最終更新日2013-12-11
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
5J4U
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CRYSTAL STRUCTURE OF A GLUTATHIONE S-TRANSFERASE PTGSTU30 FROM POPULUS TRICHOCARPA IN COMPLEX WITH GSH
分子名称:Glutathione transferase family protein, GLUTATHIONE
著者Yang, Q., Gu, J., Yang, M., Zeng, Q.
登録日2016-04-01
公開日2017-04-12
実験手法X-RAY DIFFRACTION (1.249 Å)
主引用文献Functional and Structural Profiles of GST Gene Family from Three Populus Species Revealed the Sequence-function Decoupling of Orthologous Genes
To Be Published
4OU1
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CRYSTAL STRUCTURE OF A COMPUTATIONALLY DESIGNED RETRO-ALDOLASE COVALENTLY BOUND TO FOLDING PROBE 1 [(6-METHOXYNAPHTHALEN-2-YL)(OXIRAN-2-YL)METHANOL]
分子名称:Retro-aldolase, design RA114, (1S,2S)-1-(6-methoxynaphthalen-2-yl)propane-1,2-diol, ...
著者Bhabha, G., Zhang, X., Ekiert, D.C.
登録日2014-02-14
公開日2014-03-05
最終更新日2014-04-23
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts.
Proc.Natl.Acad.Sci.USA, 111, 2014
4YDM
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN BOUND TO LIGAND AND CONJUGATES OF 3-(5-(3,5-DICHLORO-4-HYDROXYPHENYL)-1,3,4-OXADIAZOL-2-YL)PHENYL FLUOROSULFATE
分子名称:Transthyretin, 2,6-dichloro-4-[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol
著者Connelly, S., Bradbury, N.C.
登録日2015-02-22
公開日2015-07-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans.
J.Am.Chem.Soc., 137, 2015
5EWU
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA C-TERMINAL CHLH AT 1.25A
分子名称:Magnesium-chelatase subunit ChlH, chloroplastic, BENZOIC ACID, ...
著者Chen, Z., Zhang, X., Liu, Y., Jiang, L.
登録日2015-11-21
公開日2016-12-07
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of the Arabidopsis thaliana C-terminal Chlh at 1.25A
To Be Published
6BHD
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION, ...
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
4LYP
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CRYSTAL STRUCTURE OF GLYCOSIDE HYDROLASE FAMILY 5 MANNOSIDASE FROM RHIZOMUCOR MIEHEI
分子名称:Exo-beta-1,4-mannosidase, GUANIDINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Jiang, Z.Q., Zhou, P., Yang, S.Q., Liu, Y., Yan, Q.J.
登録日2013-07-31
公開日2014-08-06
最終更新日2014-11-26
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Structural insights into the substrate specificity and transglycosylation activity of a fungal glycoside hydrolase family 5 beta-mannosidase.
Acta Crystallogr.,Sect.D, 70, 2014
3TV3
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CRYSTAL STRUCTURE OF BROAD AND POTENT HIV-1 NEUTRALIZING ANTIBODY PGT128 IN COMPLEX WITH MAN9
分子名称:PGT128 light chain, Ig lambda-2 chain C regions, PGT128 heavy chain, ...
著者Pejchal, R., Wilson, I.A.
登録日2011-09-19
公開日2011-10-19
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
6B0V
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-107 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one, ...
著者Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M.R., Li, L.-S., Ren, P., Liu, Y., Zarrinkar, P.P.
登録日2017-09-15
公開日2018-05-16
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.
Nat. Struct. Mol. Biol., 25, 2018
4GEV
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E. COLI THYMIDYLATE SYNTHASE Y209W VARIANT IN COMPLEX WITH SUBSTRATE AND A COFACTOR ANALOG
分子名称:Thymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
著者Newby, Z., Lee, T.T., Finer-Moore, J., Stroud, R.M.
登録日2012-08-02
公開日2012-08-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.
J.Am.Chem.Soc., 134, 2012
5GWN
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CRYSTAL STRUCTURE OF HUMAN RCC2
分子名称:Protein RCC2, SULFATE ION
著者Liang, L., Yun, C.H., Yin, Y.X.
登録日2016-09-12
公開日2017-09-13
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.309 Å)
主引用文献RCC2 is a novel p53 target in suppressing metastasis.
Oncogene, 37, 2018
4ENF
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CRYSTAL STRUCTURE OF THE CAP-BINDING DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/PUERTO RICO/8/34(H1N1)
分子名称:Polymerase basic protein 2, NITRATE ION, 1,4-BUTANEDIOL
著者Meng, G., Liu, Y., Zheng, X.
登録日2012-04-13
公開日2013-03-06
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus
J.Biol.Chem., 288, 2013
6GSC
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SPHINGOBACTERIUM SP. T2 MANGANESE SUPEROXIDE DISMUTASE CATALYSES THE OXIDATIVE DEMETHYLATION OF POLYMERIC LIGNIN VIA GENERATION OF HYDROXYL RADICAL
分子名称:Superoxide dismutase, MANGANESE (II) ION
著者Rashid, G.M.M., Zhang, X., Wilkinson, R.C., Fulop, V., Cottyn, B., Baumberger, S., Bugg, T.D.H.
登録日2018-06-13
公開日2018-10-03
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Sphingobacterium sp. T2 Manganese Superoxide Dismutase Catalyzes the Oxidative Demethylation of Polymeric Lignin via Generation of Hydroxyl Radical.
ACS Chem. Biol., 13, 2018
5VEI
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF HUMAN SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 2
分子名称:Sorbin and SH3 domain-containing protein 2, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-04-04
公開日2017-08-02
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
To be Published
3MO7
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CRYSTAL STRUCTURE OF HUMAN OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE COVALENTLY MODIFIED BY 2'-FLUORO-6-IODO-UMP
分子名称:Uridine 5'-monophosphate synthase, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL
著者Liu, Y., Kotra, L.P., Pai, E.F.
登録日2010-04-22
公開日2011-04-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
J.Med.Chem., 54, 2011