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7BZ5
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STRUCTURE OF COVID-19 VIRUS SPIKE RECEPTOR-BINDING DOMAIN COMPLEXED WITH A NEUTRALIZING ANTIBODY
分子名称:Spike protein S1, Heavy chain of B38, Light chain of B38, ...
著者Wu, Y., Qi, J., Gao, F.
登録日2020-04-26
公開日2020-05-13
最終更新日2020-05-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Science, 2020
6VBN
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CRYSTAL STRUCTURE OF HTDO2 BOUND TO INHIBITOR GNE1
分子名称:Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol
著者Harris, S.F., Oh, A.
登録日2019-12-19
公開日2020-05-06
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Acs Med.Chem.Lett., 11, 2020
6V2S
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF MPP8 IN COMPLEX WITH INHIBITOR UNC3866
分子名称:M-phase phosphoprotein 8, UNC3866, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-11-25
公開日2019-12-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866
to be published
6V2R
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX7 MUTANT V13A IN COMPLEX WITH INHIBITOR UNC3866
分子名称:Chromobox protein homolog 7, UNC3866, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-11-25
公開日2019-12-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
to be published
6V2D
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CDYL2 IN COMPLEX WITH INHIBITOR UNC3866
分子名称:Chromodomain Y-like protein 2, UNC3866, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-11-22
公開日2019-12-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of chromodomain of CDYL2 in complex with inhibitor UNC3866
to be published
6UPL
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STRUCTURE OF FACT_SUBNUCLEOSOME COMPLEX 2
分子名称:Histone H3.1, Histone H4, Histone H2A, ...
著者Zhou, K., Tan, Y.Z., Wei, H., Liu, Y., Carragher, B., Potter, C., Luger, K.
登録日2019-10-17
公開日2019-12-11
最終更新日2020-01-29
実験手法ELECTRON MICROSCOPY (7.4 Å)
主引用文献FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
6UPK
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STRUCTURE OF FACT_SUBNUCLEOSOME COMPLEX 1
分子名称:Histone H3.1, Histone H4, Histone H2A, ...
著者Zhou, K., Tan, Y.Z., Wei, H., Liu, Y., Carragher, B., Potter, C., Luger, K.
登録日2019-10-17
公開日2019-12-11
最終更新日2020-01-29
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
6UE6
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PWWP1 DOMAIN OF NSD2 IN COMPLEX WITH MR837
分子名称:Histone-lysine N-methyltransferase NSD2, 4-cyano-N-cyclopropyl-N-[(thiophen-2-yl)methyl]benzamide, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., De Freitas, R.F., Schapira, M., Brown, P.J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC)
登録日2019-09-20
公開日2019-11-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献PWWP1 domain of NSD2 in complex with MR837
To Be Published
6U95
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ADENO-ASSOCIATED VIRUS STRAIN AAVHU.37 CAPSID ICOSAHEDRAL STRUCTURE
分子名称:Capsid protein VP1
著者Kaelber, J.T., Yost, S.A., Firlar, E., Mercer, A.C.
登録日2019-09-06
公開日2019-09-18
最終更新日2020-02-19
実験手法ELECTRON MICROSCOPY (2.56 Å)
主引用文献Structure of the AAVhu.37 capsid by cryoelectron microscopy
Acta Crystallogr.,Sect.F, 76, 2020
6U8A
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CBD-BOUND FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 1
分子名称:Transient receptor potential cation channel subfamily V member 2, cannabidiol
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U88
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CBD-BOUND FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 2
分子名称:Transient receptor potential cation channel subfamily V member 2, cannabidiol
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U86
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APO FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 2
分子名称:Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U84
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APO FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 1
分子名称:Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6RYK
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CRYSTAL STRUCTURE OF THE PARB-LIKE PROTEIN PADC
分子名称:ParB-like nuclease domain protein, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Altegoer, F., Bange, G.
登録日2019-06-10
公開日2020-01-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches.
Cell, 179, 2019
6RYB
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STRUCTURE OF DEUBIQUITINASE FOR PR-UBIQUITINATION 1 -DUP1
分子名称:Septation initiation protein
著者Donghyuk, S., Ivan, D.
登録日2019-06-10
公開日2019-11-13
最終更新日2020-05-27
実験手法X-RAY DIFFRACTION (2.315 Å)
主引用文献Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.
Mol.Cell, 77, 2020
6RYA
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STRUCTURE OF DUP1 MUTANT H67A:UBIQUITIN COMPLEX
分子名称:Septation initiation protein, Polyubiquitin-C
著者Donghyuk, S., Ivan, D.
登録日2019-06-10
公開日2019-11-13
最終更新日2020-05-27
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.
Mol.Cell, 77, 2020
6R47
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THE STRUCTURE OF PISTOL RIBOZYME BOUND TO MAGNESIUM
分子名称:RNA (50-MER), RNA, MAGNESIUM ION
著者Lilley, D.M.J., Wilson, T.M., Liu, Y.
登録日2019-03-22
公開日2019-07-03
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
J.Am.Chem.Soc., 141, 2019
6PSF
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RHINOVIRUS C15 COMPLEXED WITH DOMAINS I AND II OF RECEPTOR CDHR3
分子名称:Capsid protein VP1, Capsid protein VP3, Capsid protein VP2, ...
著者Sun, Y., Watters, K., Klose, T., Palmenberg, A.C.
登録日2019-07-12
公開日2020-03-11
最終更新日2020-04-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PPO
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RHINOVIRUS C15 COMPLEXED WITH DOMAIN I OF RECEPTOR CDHR3
分子名称:Capsid protein VP1, Capsid protein VP3, Capsid protein VP2, ...
著者Sun, Y., Watters, K., Klose, T., Palmenberg, A.C.
登録日2019-07-08
公開日2020-03-11
最終更新日2020-04-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor.
Proc.Natl.Acad.Sci.USA, 117, 2020
6P9V
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CRYSTAL STRUCTURE OF HMAT MUTANT K289L
分子名称:S-adenosylmethionine synthase isoform type-2, ADENOSINE, POTASSIUM ION, ...
著者Miller, M.D., Xu, W., Huber, T.D., Clinger, J.A., Liu, Y., Thorson, J.S., Philips Jr., G.N.
登録日2019-06-10
公開日2020-04-22
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes.
Acs Chem.Biol., 15, 2020
6OJ0
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CRYO-EM RECONSTRUCTION OF SULFOLOBUS POLYHEDRAL VIRUS 1 (SPV1)
分子名称:Structural protein VP4, Uncharacterized protein
著者Wang, F., Liu, Y., Conway, J.F., Krupovic, M., Prangishvili, D., Egelman, E.H.
登録日2019-04-10
公開日2019-10-02
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献A packing for A-form DNA in an icosahedral virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OAI
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CRYSTAL STRUCTURE OF P[6] ROTAVIRUS VP8* COMPLEXED WITH LNFPI
分子名称:Protease-sensitive outer capsid protein, 6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose
著者Xu, S., Liu, Y., Jiang, X., Kennedy, M.A.
登録日2019-03-16
公開日2020-03-18
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens.
Plos Pathog., 16, 2020
6O8C
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CRYSTAL STRUCTURE OF STING CTT IN COMPLEX WITH TBK1
分子名称:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
著者Li, P., Zhao, B., Du, F.
登録日2019-03-09
公開日2019-05-22
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6O8B
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CRYSTAL STRUCTURE OF STING CTD IN COMPLEX WITH TBK1
分子名称:Stimulator of interferon genes protein, Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
著者Li, P., Zhao, B., Du, F.
登録日2019-03-09
公開日2019-05-22
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6O5I
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MENIN IN COMPLEX WITH MI-3454
分子名称:Menin, ~{N}-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]methanamide, DIMETHYL SULFOXIDE, ...
著者Linhares, B.M., Klossowski, S., Cierpicki, T., Grembecka, J.
登録日2019-03-03
公開日2020-01-08
最終更新日2020-02-19
実験手法X-RAY DIFFRACTION (1.240256 Å)
主引用文献Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J.Clin.Invest., 130, 2020