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1M63
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BU of 1m63 by Molmil
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
Descriptor: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ...
Authors:Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H.
Deposit date:2002-07-12
Release date:2002-09-25
Last modified:2021-07-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
5MEI
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BU of 5mei by Molmil
Crystal structure of Agelastatin A bound to the 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O.
Deposit date:2016-11-15
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
3P57
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BU of 3p57 by Molmil
Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA
Descriptor: DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ...
Authors:He, J, Ye, J, Riquelme, C, Liu, J.O.
Deposit date:2010-10-08
Release date:2011-08-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1921 Å)
Cite:Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
1TQE
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BU of 1tqe by Molmil
Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2
Descriptor: Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B
Authors:Chen, L, Han, A, He, J, Wu, Y, Liu, J.O.
Deposit date:2004-06-17
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2.
J.Mol.Biol., 345, 2005
1Y1N
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BU of 1y1n by Molmil
Identification of SH3 motif in M. Tuberculosis methionine aminopeptidase suggests a mode of interaction with the ribosome
Descriptor: Methionine aminopeptidase 1B, POTASSIUM ION
Authors:Addlagatta, A, Quillin, M.L, Omotoso, O, Liu, J.O, Matthews, B.W.
Deposit date:2004-11-18
Release date:2005-05-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Identification of an SH3-Binding Motif in a New Class of Methionine Aminopeptidases from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome
Biochemistry, 44, 2005
1YJ3
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BU of 1yj3 by Molmil
Crystal structure analysis of product bound methionine aminopeptidase Type 1c from Mycobacterium Tuberculosis
Descriptor: BETA-MERCAPTOETHANOL, COBALT (II) ION, METHIONINE, ...
Authors:Addlagatta, A, Quillin, M.L, Omotoso, O, Liu, J.O, Matthews, B.W.
Deposit date:2005-01-13
Release date:2005-07-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.
Biochemistry, 44, 2005
1N6J
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BU of 1n6j by Molmil
Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2
Descriptor: 5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3', Calcineurin-binding protein Cabin 1, ...
Authors:Han, A, Pan, F, Stroud, J.C, Youn, H.D, Liu, J.O, Chen, L.
Deposit date:2002-11-11
Release date:2003-11-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2
Nature, 422, 2003
2B3K
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BU of 2b3k by Molmil
Crystal structure of Human Methionine Aminopeptidase Type I in the holo form
Descriptor: ACETATE ION, COBALT (II) ION, GLYCEROL, ...
Authors:Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2B3L
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BU of 2b3l by Molmil
Crystal structure of type I human methionine aminopeptidase in the apo form
Descriptor: ACETIC ACID, GLYCEROL, Methionine aminopeptidase 1, ...
Authors:Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2B3H
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BU of 2b3h by Molmil
Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site
Descriptor: CHLORIDE ION, COBALT (II) ION, GLYCEROL, ...
Authors:Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2G6P
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BU of 2g6p by Molmil
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE, COBALT (II) ION, ...
Authors:Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W.
Deposit date:2006-02-24
Release date:2006-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases.
Angew.Chem.Int.Ed.Engl., 45, 2006
7MU5
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BU of 7mu5 by Molmil
Human DCTPP1 bound to Triptolide
Descriptor: MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide
Authors:Hauk, G, Berger, J.M.
Deposit date:2021-05-14
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
To Be Published
4RDD
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BU of 4rdd by Molmil
Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11
Authors:Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y.
Deposit date:2014-09-18
Release date:2015-07-01
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015
4HXX
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BU of 4hxx by Molmil
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Descriptor: (1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine, COBALT (II) ION, Methionine aminopeptidase 1, ...
Authors:Gabelli, S.B, Zhang, F, Liu, J, Amzel, L.M.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Bioorg.Med.Chem., 21, 2013
4IU6
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BU of 4iu6 by Molmil
Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1
Descriptor: 4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-(pyridin-2-yl)quinazoline, COBALT (II) ION, Methionine aminopeptidase 1, ...
Authors:Gabelli, S.B, Zhang, F, Miller, M, Liu, J, Amzel, L.M.
Deposit date:2013-01-19
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
J.Med.Chem., 56, 2013
2NQ7
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BU of 2nq7 by Molmil
Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide
Descriptor: 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE, COBALT (II) ION, GLYCEROL, ...
Authors:Addlagatta, A, Matthews, B.W.
Deposit date:2006-10-30
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2NQ6
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BU of 2nq6 by Molmil
Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-Butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2-ylamide
Descriptor: CALCIUM ION, COBALT (II) ION, GLYCEROL, ...
Authors:Addlagatta, A, Matthews, B.W.
Deposit date:2006-10-30
Release date:2006-11-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2OJU
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BU of 2oju by Molmil
X-ray structure of complex of human cyclophilin J with cyclosporin A
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3
Authors:Xia, Z, Huang, L.
Deposit date:2007-01-14
Release date:2008-01-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeting Cyclophilin J, a Novel Peptidyl-Prolyl Isomerase, Can Induce Cellular G1/S Arrest and Repress the Growth of Hepatocellular Carcinoma
To be Published
2OK3
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BU of 2ok3 by Molmil
X-ray structure of human cyclophilin J at 2.0 angstrom
Descriptor: NICKEL (II) ION, Peptidyl-prolyl cis-trans isomerase-like 3
Authors:Xia, Z.
Deposit date:2007-01-15
Release date:2008-01-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting Cyclophilin J, a novel peptidyl-prolyl isomerase, can induce cellular G1/S arrest and repress the growth of Hepatocellular carcinoma
To be Published
4IKT
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BU of 4ikt by Molmil
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine
Descriptor: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ...
Authors:Addlagatta, A, Kishor, C, Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKS
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BU of 4iks by Molmil
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine
Descriptor: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ...
Authors:Addlagatta, A, Kishor, C, Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKU
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BU of 4iku by Molmil
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
Descriptor: COBALT (II) ION, Methionine aminopeptidase 1, Nalpha-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-D-phenylalaninamide, ...
Authors:Addlagatta, A, Kishor, C, Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKR
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BU of 4ikr by Molmil
Crystal structure of Type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol
Descriptor: 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol, COBALT (II) ION, GLYCEROL, ...
Authors:Addlagatta, A, Kishor, C, Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013

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