Author results

1M63
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CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
Descriptor:SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, ...
Authors:Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.
Deposit date:2002-07-12
Release date:2002-09-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
3P57
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CRYSTAL STRUCTURE OF THE P300 TAZ2 DOMAIN BOUND TO MEF2 ON DNA
Descriptor:Myocyte-specific enhancer factor 2A, DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), ...
Authors:He, J., Ye, J., Riquelme, C., Liu, J.O.
Deposit date:2010-10-08
Release date:2011-08-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1921 Å)
Cite:Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
1N6J
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STRUCTURAL BASIS OF SEQUENCE-SPECIFIC RECRUITMENT OF HISTONE DEACETYLASES BY MYOCYTE ENHANCER FACTOR-2
Descriptor:5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3', Myocyte-specific enhancer factor 2B, ...
Authors:Han, A., Pan, F., Stroud, J.C., Youn, H.D., Liu, J.O., Chen, L.
Deposit date:2002-11-11
Release date:2003-11-11
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2
Nature, 422, 2003
1TQE
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MECHANISM OF RECRUITMENT OF CLASS II HISTONE DEACETYLASES BY MYOCYTE ENHANCER FACTOR-2
Descriptor:MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B, Histone deacetylase 9
Authors:Chen, L., Han, A., He, J., Wu, Y., Liu, J.O.
Deposit date:2004-06-17
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2.
J.Mol.Biol., 345, 2005
1Y1N
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IDENTIFICATION OF SH3 MOTIF IN M. TUBERCULOSIS METHIONINE AMINOPEPTIDASE SUGGESTS A MODE OF INTERACTION WITH THE RIBOSOME
Descriptor:Methionine aminopeptidase 1B, POTASSIUM ION
Authors:Addlagatta, A., Quillin, M.L., Omotoso, O., Liu, J.O., Matthews, B.W.
Deposit date:2004-11-18
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Identification of an SH3-Binding Motif in a New Class of Methionine Aminopeptidases from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome
Biochemistry, 44, 2005
1YJ3
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CRYSTAL STRUCTURE ANALYSIS OF PRODUCT BOUND METHIONINE AMINOPEPTIDASE TYPE 1C FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Methionine aminopeptidase, COBALT (II) ION, POTASSIUM ION, ...
Authors:Addlagatta, A., Quillin, M.L., Omotoso, O., Liu, J.O., Matthews, B.W.
Deposit date:2005-01-13
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.
Biochemistry, 44, 2005
2B3H
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CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE TYPE I WITH A THIRD COBALT IN THE ACTIVE SITE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Addlagatta, A., Hu, X., Liu, J.O., Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2B3K
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CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE TYPE I IN THE HOLO FORM
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Addlagatta, A., Hu, X., Liu, J.O., Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2B3L
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CRYSTAL STRUCTURE OF TYPE I HUMAN METHIONINE AMINOPEPTIDASE IN THE APO FORM
Descriptor:Methionine aminopeptidase 1, POTASSIUM ION, GLYCEROL, ...
Authors:Addlagatta, A., Hu, X., Liu, J.O., Matthews, B.W.
Deposit date:2005-09-20
Release date:2005-11-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
Biochemistry, 44, 2005
2G6P
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH PYRIDYL PYRIMIDINE DERIVATIVE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Addlagatta, A., Hu, X., Liu, J.O., Matthews, B.W.
Deposit date:2006-02-24
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases.
Angew.Chem.Int.Ed.Engl., 45, 2006
5MEI
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CRYSTAL STRUCTURE OF AGELASTATIN A BOUND TO THE 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J.C.P., Lu, J., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R., Liu, J.O.
Deposit date:2016-11-15
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
4HXX
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PYRIDINYLPYRIMIDINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Gabelli, S.B., Zhang, F., Liu, J., Amzel, L.M.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Bioorg.Med.Chem., 21, 2013
4IU6
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HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH FZ1: PYRIDINYLQUINAZOLINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.
Deposit date:2013-01-19
Release date:2013-05-01
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
J.Med.Chem., 56, 2013
2NQ6
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CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH 3-TERT-BUTOXYCARBONYLAMINOPYRIDINE-2-CARBOXYLIC ACID THIAZOLE-2-YLAMIDE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, CALCIUM ION, ...
Authors:Addlagatta, A., Matthews, B.W.
Deposit date:2006-10-30
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2NQ7
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CRYSTAL STRUCTURE OF TYPE 1 HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH 3-(2,2-DIMETHYLPROPIONYLAMINO)PYRIDINE-2-CARBOXYLIC ACID THIAZOLE-2-YLAMIDE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Addlagatta, A., Matthews, B.W.
Deposit date:2006-10-30
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2OJU
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X-RAY STRUCTURE OF COMPLEX OF HUMAN CYCLOPHILIN J WITH CYCLOSPORIN A
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3, CYCLOSPORIN A
Authors:Xia, Z., Huang, L.
Deposit date:2007-01-14
Release date:2008-01-22
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeting Cyclophilin J, a Novel Peptidyl-Prolyl Isomerase, Can Induce Cellular G1/S Arrest and Repress the Growth of Hepatocellular Carcinoma
To be Published
2OK3
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X-RAY STRUCTURE OF HUMAN CYCLOPHILIN J AT 2.0 ANGSTROM
Descriptor:Peptidyl-prolyl cis-trans isomerase-like 3, NICKEL (II) ION
Authors:Xia, Z.
Deposit date:2007-01-15
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting Cyclophilin J, a novel peptidyl-prolyl isomerase, can induce cellular G1/S arrest and repress the growth of Hepatocellular carcinoma
To be Published
4IKR
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CRYSTAL STRUCTURE OF TYPE 1 HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH 2-(4-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)PIPERAZIN-1-YL)ETHANOL
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKS
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH N1-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)-N2-(6-(TRIFLUOROMETHYL)PYRIDIN-2-YL)ETHANE-1,2-DIAMINE
Descriptor:Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKT
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH N1-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)-N2-(5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)ETHANE-1,2-DIAMINE
Descriptor:Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKU
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH 2-((5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)AMINO)-3-PHENYLPROPANAMIDE
Descriptor:Methionine aminopeptidase 1, Nalpha-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-D-phenylalaninamide, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4RDD
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CO-CRYSTAL STRUCTURE OF SHP2 IN COMPLEX WITH A CEFSULODIN DERIVATIVE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium
Authors:Zhang, Z.Y., Yu, Z.H., He, R., Zhang, R.Y.
Deposit date:2014-09-18
Release date:2015-07-01
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015