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3O62
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BU of 3o62 by Molmil
Nucleosome core particle modified with a cisplatin 1,3-cis-{Pt(NH3)2}2+-d(GpTpG) intrastrand cross-link
Descriptor: Cisplatin, DNA (146-MER), Histone H2A type 1, ...
Authors:Lippard, S.J, Todd, R.C.
Deposit date:2010-07-28
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.216 Å)
Cite:Consequences of Cisplatin binding on nucleosome structure and dynamics.
Chem.Biol., 17, 2010
1AIO
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BU of 1aio by Molmil
CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN
Descriptor: Cisplatin, DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3')
Authors:Takahara, P.M, Rosenzweig, A.C, Frederick, C.A, Lippard, S.J.
Deposit date:1997-04-23
Release date:1997-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Nature, 377, 1995
4GAM
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BU of 4gam by Molmil
Complex structure of Methane monooxygenase hydroxylase and regulatory subunit
Descriptor: FE (III) ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ...
Authors:Lee, S.J, Lippard, S.J, Cho, U.-S.
Deposit date:2012-07-25
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Control of substrate access to the active site in methane monooxygenase.
Nature, 494, 2013
1MTY
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BU of 1mty by Molmil
METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH)
Descriptor: FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE
Authors:Rosenzweig, A.C, Nordlund, P, Lippard, S.J, Frederick, C.A.
Deposit date:1996-07-10
Release date:1997-04-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins, 29, 1997
1A84
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BU of 1a84 by Molmil
NMR SOLUTION STRUCTURE OF A DNA DODECAMER DUPLEX CONTAINING A CIS-DIAMMINEPLATINUM(II) D(GPG) INTRASTRAND CROSS-LINK, THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN, 1 STRUCTURE
Descriptor: Cisplatin, DNA D(CCTCTG*G*TCTCC), DNA D(GGAGACCAGAGG)
Authors:Gelasco, A, Lippard, S.J.
Deposit date:1998-04-02
Release date:1998-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin.
Biochemistry, 37, 1998
3CO3
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BU of 3co3 by Molmil
X-Ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2(pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex
Descriptor: 5'-D(*DCP*DCP*DTP*DCP*DTP*DCP*DGP*DTP*DCP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DGP*DAP*DGP*DAP*DGP*DG)-3', cis-diammine(pyridine)chloroplatinum(II)
Authors:Lovejoy, K.S, Todd, R.C, Zhang, S, McCormick, M.S, D'Aquino, J.A, Reardon, J.T, Sancar, A, Giacomini, K.M, Lippard, S.J.
Deposit date:2008-03-27
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3LPV
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BU of 3lpv by Molmil
X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link
Descriptor: 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', Cisplatin, ...
Authors:Todd, R.C, Lippard, S.J.
Deposit date:2010-02-06
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link at 1.77A resolution.
J.Inorg.Biochem., 104, 2010
2RDB
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BU of 2rdb by Molmil
X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase I100W Mutant
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE (III) ION, GLYCEROL, ...
Authors:Murray, L.J, Garcia-Serres, R, McCormick, M.S, Davydov, R, Naik, S, Hoffman, B.M, Huynh, B.H, Lippard, S.J.
Deposit date:2007-09-21
Release date:2007-12-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.
Biochemistry, 46, 2007
3U52
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BU of 3u52 by Molmil
X-ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas sp. OX1
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, COPPER (II) ION, ...
Authors:McCormick, M.S, Lippard, S.J.
Deposit date:2011-10-10
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas sp. OX1.
Biochemistry, 50, 2011
1LU5
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BU of 1lu5 by Molmil
2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex
Descriptor: 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX
Authors:Silverman, A.P, Bu, W, Cohen, S.M, Lippard, S.J.
Deposit date:2002-05-21
Release date:2002-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex
J.Biol.Chem., 277, 2002
2IND
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BU of 2ind by Molmil
Mn(II) Reconstituted Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure
Descriptor: HEXAETHYLENE GLYCOL, MANGANESE (II) ION, Toluene, ...
Authors:McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J.
Deposit date:2006-10-06
Release date:2006-12-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
2INP
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BU of 2inp by Molmil
Structure of the Phenol Hydroxylase-Regulatory Protein Complex
Descriptor: FE (III) ION, Phenol hydroxylase component phL, Phenol hydroxylase component phM, ...
Authors:Sazinsky, M.S, Dunten, P.W, McCormick, M.S, Lippard, S.J.
Deposit date:2006-10-08
Release date:2007-01-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
2INC
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BU of 2inc by Molmil
Native Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure
Descriptor: FE (III) ION, HEXAETHYLENE GLYCOL, Toluene, ...
Authors:McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J.
Deposit date:2006-10-06
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
2INN
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BU of 2inn by Molmil
Structure of the Phenol Hydroxyalse-Regulatory Protein Complex
Descriptor: FE (III) ION, MOLYBDATE ION, Phenol hydroxylase component phL, ...
Authors:Sazinsky, M.H, Dunten, P.W, McCormick, M.S, Lippard, S.J.
Deposit date:2006-10-08
Release date:2007-01-16
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
1IHH
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BU of 1ihh by Molmil
2.4 ANGSTROM CRYSTAL STRUCTURE OF AN OXALIPLATIN 1,2-D(GPG) INTRASTRAND CROSS-LINK IN A DNA DODECAMER DUPLEX
Descriptor: 1R,2R-DIAMINOCYCLOHEXANE, 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', ...
Authors:Spingler, B, Whittington, D.A, Lippard, S.J.
Deposit date:2001-04-19
Release date:2001-10-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
Inorg.Chem., 40, 2001
1JQ4
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BU of 1jq4 by Molmil
[2Fe-2S] Domain of Methane Monooxygenase Reductase from Methylococcus capsulatus (Bath)
Descriptor: FE2/S2 (INORGANIC) CLUSTER, METHANE MONOOXYGENASE COMPONENT C
Authors:Mueller, J, Lugovskoy, A.A, Wagner, G, Lippard, S.J.
Deposit date:2001-08-03
Release date:2002-01-09
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase.
Biochemistry, 41, 2002
3RNA
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BU of 3rna by Molmil
Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/I100W Double Mutant
Descriptor: FE (III) ION, HYDROXIDE ION, Toluene o-xylene monooxygenase component
Authors:Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H.
Deposit date:2011-04-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RNC
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BU of 3rnc by Molmil
Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/I100A Double Mutant
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, HYDROXIDE ION, ...
Authors:Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H.
Deposit date:2011-04-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RNF
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BU of 3rnf by Molmil
Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/V271A Double Mutant
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, PENTAETHYLENE GLYCOL, ...
Authors:Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H.
Deposit date:2011-04-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RNE
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BU of 3rne by Molmil
Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/I276E Double Mutant
Descriptor: FE (III) ION, HYDROXIDE ION, Toluene o-xylene monooxygenase component
Authors:Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H.
Deposit date:2011-04-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RN9
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BU of 3rn9 by Molmil
Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/L272E Double Mutant
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, HYDROXIDE ION, ...
Authors:Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H.
Deposit date:2011-04-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
3M4O
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BU of 3m4o by Molmil
RNA polymerase II elongation complex B
Descriptor: DNA (28-MER), DNA (5'-D(P*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, D, Zhu, G, Huang, X, Lippard, S.J.
Deposit date:2010-03-11
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.57 Å)
Cite:X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
3M3Y
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BU of 3m3y by Molmil
RNA polymerase II elongation complex C
Descriptor: DNA (28-MER), DNA (5'-D(*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, D, Zhu, G, Huang, X, Lippard, S.J.
Deposit date:2010-03-10
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
3N1Y
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BU of 3n1y by Molmil
X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201G Mutant
Descriptor: FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:McCormick, M.S, Sazinsky, M.H, Lippard, S.J.
Deposit date:2010-05-17
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
3N1Z
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BU of 3n1z by Molmil
X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201S Mutant
Descriptor: FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:McCormick, M.S, Sazinsky, M.H, Lippard, S.J.
Deposit date:2010-05-17
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010

 

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