Author results

4CXP
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STRUCTURE OF BIFUNCTIONAL ENDONUCLEASE (ATBFN2) FROM ARABIDOPSIS THALIANA IN COMPLEX WITH SULFATE
Descriptor:ENDONUCLEASE 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Yu, T.-F., Maestre-Reyna, M., Ko, C.-Y., Ko, T.-P., Sun, Y.-J., Lin, T.-Y., Shaw, J.-F., Wang, A.H.-J.
Deposit date:2014-04-08
Release date:2014-07-23
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
5C1U
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND XB
Descriptor:3C proteinase, Nalpha-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
2OOA
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CRYSTAL STRUCTURE OF THE UBA DOMAIN FROM CBL-B UBIQUITIN LIGASE
Descriptor:E3 ubiquitin-protein ligase CBL-B
Authors:Kozlov, G., Gehring, K.
Deposit date:2007-01-25
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
Mol.Cell, 27, 2007
4FVD
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CRYSTAL STRUCTURE OF EV71 2A PROTEINASE C110A MUTANT IN COMPLEX WITH SUBSTRATE
Descriptor:2A proteinase, 10-mer peptide from 2A proteinase, ZINC ION
Authors:Cai, Q., Muhammad, Y., Liu, W., Gao, Z., Peng, X., Cai, Y., Wu, C., Zheng, Q., Li, J., Lin, T.
Deposit date:2012-06-29
Release date:2013-06-19
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Conformational Plasticity of 2A Proteinase from Enterovirus 71
J.Virol., 87, 2013
4CXO
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BIFUNCTIONAL ENDONUCLEASE IN COMPLEX WITH SSDNA
Descriptor:ENDONUCLEASE 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Yu, T.-F., Maestre-Reyna, M., Ko, C.-Y., Ko, T.-P., Sun, Y.-J., Lin, T.-Y., Shaw, J.-F., Wang, A.H.-J.
Deposit date:2014-04-08
Release date:2014-07-23
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
5TTU
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JAK3 WITH COVALENT INHIBITOR 7
Descriptor:Tyrosine-protein kinase JAK3, 1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2016-11-04
Release date:2017-02-22
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60, 2017
5I0H
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CRYSTAL STRUCTURE OF MYOSIN X MOTOR DOMAIN IN PRE-POWERSTROKE STATE
Descriptor:Unconventional myosin-X, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Isabet, T., Blanc, F., Sweeney, H.L., Houdusse, A.
Deposit date:2016-02-04
Release date:2016-09-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5L2H
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CRYSTAL STRUCTURE OF W26A MUTANT OF ANTI-EGFR CENTYRIN P54AR4-83V2
Descriptor:Centyrin, GLYCEROL
Authors:Cardoso, R.M.F., Goldberg, S.D., O Neil, K.T., Gilliland, G.L.
Deposit date:2016-08-01
Release date:2016-11-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8013 Å)
Cite:Engineering a targeted delivery platform using Centyrins.
Protein Eng. Des. Sel., 29, 2016
3QMX
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X-RAY CRYSTAL STRUCTURE OF SYNECHOCYSTIS SP. PCC 6803 GLUTAREDOXIN A
Descriptor:Glutaredoxin A, SULFATE ION
Authors:Sutton, R.B., Knaff, D.B.
Deposit date:2011-02-05
Release date:2012-01-11
Method:X-RAY DIFFRACTION (1.822 Å)
Cite:Redox, mutagenic and structural studies of the glutaredoxin/arsenate reductase couple from the cyanobacterium Synechocystis sp. PCC 6803.
Biochim.Biophys.Acta, 1824, 2011
2QHO
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CRYSTAL STRUCTURE OF THE UBA DOMAIN FROM EDD UBIQUITIN LIGASE IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin, E3 ubiquitin-protein ligase EDD1
Authors:Kozlov, G., Gehring, K.
Deposit date:2007-07-02
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD.
J.Biol.Chem., 282, 2007
5C1X
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND VIII
Descriptor:3C proteinase, Nalpha-[(benzyloxy)carbonyl]-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
2OOB
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CRYSTAL STRUCTURE OF THE UBA DOMAIN FROM CBL-B UBIQUITIN LIGASE IN COMPLEX WITH UBIQUITIN
Descriptor:E3 ubiquitin-protein ligase CBL-B, Ubiquitin
Authors:Kozlov, G., Gehring, K.
Deposit date:2007-01-25
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
Mol.Cell, 27, 2007
4FVB
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CRYSTAL STRUCTURE OF EV71 2A PROTEINASE C110A MUTANT
Descriptor:2A proteinase, ZINC ION
Authors:Cai, Q., Muhammad, Y., Liu, W., Gao, Z., Peng, X., Cai, Y., Wu, C., Zheng, Q., Li, J., Lin, T.
Deposit date:2012-06-29
Release date:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Plasticity of 2A Proteinase from Enterovirus 71
J.Virol., 87, 2013
5DP9
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 9
Descriptor:3C proteinase, ethyl (2Z,4S)-4-[(N-{[(cyclobutylmethyl)amino](oxo)acetyl}-L-phenylalanyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
Authors:Wu, C., Zhang, L., Li, P., Cai, Q., Peng, X., Li, N., Cai, Y., Li, J., Lin, T.
Deposit date:2015-09-12
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860, 2016
5TTV
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JAK3 WITH COVALENT INHIBITOR 6
Descriptor:Tyrosine-protein kinase JAK3, N-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide
Authors:Vajdos, F.F.
Deposit date:2016-11-04
Release date:2017-02-22
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
J. Med. Chem., 60, 2017
4GHT
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH AG7088
Descriptor:3C proteinase, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
Authors:Chen, C., Wu, C., Cai, Q., Li, N., Peng, X., Cai, Y., Yin, K., Chen, X., Wang, X., Zhang, R., Liu, L., Chen, S., Li, J., Lin, T.
Deposit date:2012-08-08
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir
Acta Crystallogr.,Sect.D, 69, 2013
5C1Y
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 1
Descriptor:3C proteinase, N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-Nalpha-[(propan-2-yloxy)carbonyl]-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
5TOZ
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JAK3 WITH COVALENT INHIBITOR PF-06651600
Descriptor:Tyrosine-protein kinase JAK3, 1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2016-10-19
Release date:2016-11-09
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
ACS Chem. Biol., 11, 2016
4RZF
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CRYSTAL STRUCTURE ANALYSIS OF THE NUR77 LIGAND BINDING DOMAIN, S441W MUTANT
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Li, F., Tian, X., Li, A., Li, L., Liu, Y., Chen, H., Wu, Q., Lin, T.
Deposit date:2014-12-21
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Nat.Chem.Biol., 11, 2015
4CXV
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STRUCTURE OF BIFUNCTIONAL ENDONUCLEASE (ATBFN2) IN COMPLEX WITH PHOSPHATE.
Descriptor:ENDONUCLEASE 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Yu, T.-F., Maestre-Reyna, M., Ko, C.-Y., Ko, T.-P., Sun, Y.-J., Lin, T.-Y., Shaw, J.-F., Wang, A.H.-J.
Deposit date:2014-04-09
Release date:2014-07-23
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana.
Plos One, 9, 2014
4NNG
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STRUCTURAL BASIS FOR TARGETING THE RIBOSOMAL PROTEIN S1 OF MYCOBACTERIUM TUBERCULOSIS BY PYRAZINAMIDE
Descriptor:30S ribosomal protein S1
Authors:Yang, J., Liu, Y., Cai, Q., Lin, D.
Deposit date:2013-11-18
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Mol.Microbiol., 95, 2015
5DP5
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 4
Descriptor:3C proteinase, ethyl (2Z,4S)-4-{[(2R,5S)-5-amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
Authors:Wu, C., Zhang, L., Li, P., Cai, Q., Peng, X., Li, N., Cai, Y., Li, J., Lin, T.
Deposit date:2015-09-12
Release date:2016-03-30
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860, 2016
5DP3
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 2
Descriptor:3C proteinase, ethyl (4S)-5-[(3S)-2-oxopyrrolidin-3-yl]-4-[(3-phenylpropanoyl)amino]pent-2-enoate
Authors:Wu, C., Zhang, L., Li, P., Cai, Q., Peng, X., Li, N., Cai, Y., Li, J., Lin, T.
Deposit date:2015-09-12
Release date:2016-03-30
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860, 2016
3V3E
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CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-13
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
5DPA
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 6
Descriptor:3C proteinase, ethyl (2Z,4S)-4-[(N-acetyl-L-phenylalanyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
Authors:Wu, C., Zhang, L., Li, P., Cai, Q., Peng, X., Li, N., Cai, Y., Li, J., Lin, T.
Deposit date:2015-09-12
Release date:2016-03-30
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860, 2016
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