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7KPW
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BU of 7kpw by Molmil
Structure of the H-lobe of yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
7KPV
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BU of 7kpv by Molmil
Structure of kinase and Central lobes of yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
7KPX
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BU of 7kpx by Molmil
Structure of the yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
4NHJ
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BU of 4nhj by Molmil
Crystal structure of Klebsiella pneumoniae RstA DNA-binding domain in complex with RstA box
Descriptor: 5'-D(*CP*AP*GP*GP*GP*AP*GP*TP*AP*AP*CP*GP*GP*AP*AP*TP*GP*TP*AP*CP*AP*AP*C)-3', 5'-D(*GP*GP*TP*TP*GP*TP*AP*CP*AP*TP*TP*CP*CP*GP*TP*TP*AP*CP*TP*CP*CP*CP*T)-3', DNA-binding transcriptional regulator RstA
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2013-11-05
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.
Nucleic Acids Res., 42, 2014
4NIC
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BU of 4nic by Molmil
Crystal structure of Klebsiella pneumoniae RstA BeF3-activated N-terminal receiver domain
Descriptor: BERYLLIUM TRIFLUORIDE ION, DNA-binding transcriptional regulator RstA, MAGNESIUM ION
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2013-11-06
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.
Nucleic Acids Res., 42, 2014
4OEG
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BU of 4oeg by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex
Descriptor: 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEF
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BU of 4oef by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEE
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BU of 4oee by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex
Descriptor: 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
5WTN
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BU of 5wtn by Molmil
Crystal Structure Analysis of primosome protein DnaB (resiues 1-300) from Geobacillus stearothermophilus
Descriptor: Replication initiation and membrane attachment protein
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2016-12-13
Release date:2017-08-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analyses of the bacterial primosomal protein DnaB reveal that it is a tetramer and forms a complex with a primosomal re-initiation protein
J. Biol. Chem., 292, 2017
4S05
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BU of 4s05 by Molmil
Crystal structure of Klebsiella pneumoniae PmrA in complex with PmrA box DNA
Descriptor: BERYLLIUM TRIFLUORIDE ION, DNA (26-MER), DNA-binding transcriptional regulator BasR, ...
Authors:Hsiao, C.D, Weng, T.H, Li, Y.C.
Deposit date:2014-12-30
Release date:2015-11-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
Nat Commun, 6, 2015
4S04
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BU of 4s04 by Molmil
Crystal structure of Klebsiella pneumoniae PmrA in complex with PmrA box DNA
Descriptor: BERYLLIUM TRIFLUORIDE ION, DNA (25-MER), DNA-binding transcriptional regulator BasR, ...
Authors:Hsiao, C.D, Weng, T.H, Li, Y.C.
Deposit date:2014-12-30
Release date:2015-11-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
Nat Commun, 6, 2015
4G0W
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BU of 4g0w by Molmil
Human topoisomerase iibeta in complex with DNA and ametantrone
Descriptor: 1,4-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0U
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BU of 4g0u by Molmil
Human topoisomerase IIbeta in complex with DNA and amsacrine
Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0V
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BU of 4g0v by Molmil
Human topoisomerase iibeta in complex with DNA and mitoxantrone
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4J3N
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BU of 4j3n by Molmil
Human Topoisomerase Iibeta in complex with DNA
Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2013-02-06
Release date:2013-10-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
7YIZ
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BU of 7yiz by Molmil
Crystal structure of anti-mPEG h15-2b Fab W104Y mutant
Descriptor: 15-2b W104Y heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
Authors:Chang, C.Y, Nguyen, T.M.T, Li, Y.C, Su, Y.C.
Deposit date:2022-07-18
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of anti-mPEG h15-2b Fab W104Y mutant
To Be Published
2MLK
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BU of 2mlk by Molmil
Three-dimensional structure of the C-terminal DNA-binding domain of RstA protein from Klebsiella pneumoniae
Descriptor: RstA
Authors:Fang, P, Chen, S, Cheng, Y, Chang, C, Yu, T, Huang, T.
Deposit date:2014-03-02
Release date:2014-07-16
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.
Nucleic Acids Res., 42, 2014
1BM6
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BU of 1bm6 by Molmil
SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 COMPLEXED TO A POTENT NON-PEPTIDIC INHIBITOR, NMR, 20 STRUCTURES
Descriptor: 1-METHYLOXY-4-SULFONE-BENZENE, 3-METHYLPYRIDINE, CALCIUM ION, ...
Authors:Li, Y, Zhang, X, Melton, R, Ganu, V, Gonnella, N.C.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor.
Biochemistry, 37, 1998
5QTW
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BU of 5qtw by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14-[(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1H-8,11-epimino-1,9-benzodiazacyclotridecine-2-carboxylate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-11-13
Release date:2020-01-29
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg.Med.Chem.Lett., 30, 2020
5QTV
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BU of 5qtv by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2-(trifluoromethyl)-2,3,4,5,6,7-hexahydro-1H-8,11-epimino-1,9-benzodiazacyclotridecin-14-yl]carbamate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-11-13
Release date:2020-01-29
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg.Med.Chem.Lett., 30, 2020
5QTX
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BU of 5qtx by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR ethyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14-[(methoxycarbonyl)amino]-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecine-2-carboxylate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-11-13
Release date:2020-01-29
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg.Med.Chem.Lett., 30, 2020
5QTY
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BU of 5qty by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR ethyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-15-[(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecine-2-carboxylate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-11-13
Release date:2020-01-29
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg.Med.Chem.Lett., 30, 2020
1YUF
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BU of 1yuf by Molmil
TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 16 MODELS WITHOUT ENERGY MINIMIZATION
Descriptor: TRANSFORMING GROWTH FACTOR ALPHA
Authors:Moy, F.J, Montelione, G.T, Scheraga, H.A.
Deposit date:1996-04-01
Release date:1996-08-17
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints.
Biochemistry, 32, 1993
1YUG
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BU of 1yug by Molmil
TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 15 MODELS AFTER ECEPP/3 ENERGY MINIMIZATION
Descriptor: TRANSFORMING GROWTH FACTOR ALPHA
Authors:Moy, F.J, Montelione, G.T, Scheraga, H.A.
Deposit date:1996-04-01
Release date:1996-08-17
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints.
Biochemistry, 32, 1993
4A7W
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BU of 4a7w by Molmil
Crystal structure of uridylate kinase from Helicobacter pylori
Descriptor: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, URIDYLATE KINASE
Authors:Chu, C.H, Chen, P.C, Liu, M.H, Sun, Y.J.
Deposit date:2011-11-15
Release date:2012-06-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Helicobacter Pylori Uridylate Kinase: Insight Into Release of the Product Udp
Acta Crystallogr.,Sect.D, 68, 2012

 

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