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1LBG
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BU of 1lbg by Molmil
LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY
Descriptor: DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR)
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-01-03
Release date:1996-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (4.8 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBH
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BU of 1lbh by Molmil
INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBI
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BU of 1lbi by Molmil
LAC REPRESSOR
Descriptor: LAC REPRESSOR
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
2FJR
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BU of 2fjr by Molmil
Crystal Structure of Bacteriophage 186
Descriptor: Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-03
Release date:2006-06-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch
Mol.Cell, 21, 2006
2FKD
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BU of 2fkd by Molmil
Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor
Descriptor: Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-04
Release date:2006-06-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch.
Mol.Cell, 21, 2006
1AFS
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BU of 1afs by Molmil
RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE
Descriptor: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE
Authors:Bennett, M.J, Albert, R.H, Jez, J.M, Ma, H, Penning, T.M, Lewis, M.
Deposit date:1997-03-13
Release date:1997-10-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure, 5, 1997
1EFA
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BU of 1efa by Molmil
CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
Descriptor: 2-nitrophenyl beta-D-fucopyranoside, DNA (5'-D(*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), LAC REPRESSOR
Authors:Bell, C.E, Lewis, M.
Deposit date:2000-02-07
Release date:2000-03-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A closer view of the conformation of the Lac repressor bound to operator.
Nat.Struct.Biol., 7, 2000
1LRP
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BU of 1lrp by Molmil
COMPARISON OF THE STRUCTURES OF CRO AND LAMBDA REPRESSOR PROTEINS FROM BACTERIOPHAGE LAMBDA
Descriptor: LAMBDA REPRESSOR
Authors:Pabo, C, Lewis, M.
Deposit date:1987-12-04
Release date:1989-01-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda.
J.Mol.Biol., 169, 1983
1F39
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BU of 1f39 by Molmil
CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN
Descriptor: REPRESSOR PROTEIN CI
Authors:Bell, C.E, Frescura, P, Hochschild, A, Lewis, M.
Deposit date:2000-06-01
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.
Cell(Cambridge,Mass.), 101, 2000
1LWI
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BU of 1lwi by Molmil
3-ALPHA-HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE FROM RATTUS NORVEGICUS
Descriptor: 3-ALPHA-HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bennett, M.J, Schlegel, B.P, Jez, J.M, Penning, T.M, Lewis, M.
Deposit date:1996-02-24
Release date:1996-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
Biochemistry, 35, 1996
3BDN
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BU of 3bdn by Molmil
Crystal Structure of the Lambda Repressor
Descriptor: DNA (5'-D(*DAP*DAP*DTP*DAP*DCP*DCP*DAP*DCP*DTP*DGP*DGP*DCP*DGP*DGP*DTP*DGP*DAP*DTP*DAP*DT)-3'), DNA (5'-D(*DTP*DAP*DTP*DAP*DTP*DCP*DAP*DCP*DCP*DGP*DCP*DCP*DAP*DGP*DTP*DGP*DGP*DTP*DAP*DT)-3'), Lambda Repressor
Authors:Stayrook, S.E, Jaru-Ampornpan, P, Hochschild, A, Lewis, M.
Deposit date:2007-11-15
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.909 Å)
Cite:Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding
Nature, 452, 2008
2PE5
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BU of 2pe5 by Molmil
Crystal Structure of the Lac Repressor bound to ONPG in repressed state
Descriptor: 2-nitrophenyl beta-D-galactopyranoside, DNA (5'-D(*DAP*DAP*DTP*DTP*DGP*DTP*DGP*DAP*DGP*DCP*DGP*DCP*DTP*DCP*DAP*DCP*DAP*DAP*DTP*DT)-3'), Lactose operon repressor
Authors:Daber, R, Stayrook, S.E, Rosenberg, A, Lewis, M.
Deposit date:2007-04-02
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural analysis of lac repressor bound to allosteric effectors
J.Mol.Biol., 370, 2007
1RAL
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BU of 1ral by Molmil
THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY
Descriptor: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE
Authors:Hoog, S.S, Pawlowski, J.E, Alzari, P.M, Penning, T.M, Lewis, M.
Deposit date:1994-02-04
Release date:1994-04-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
Proc.Natl.Acad.Sci.USA, 91, 1994
1IHI
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BU of 1ihi by Molmil
Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate
Descriptor: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, ISO-URSODEOXYCHOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Jin, Y, Stayrook, S.E, Albert, R.H, Palackal, N.T, Penning, T.M, Lewis, M.
Deposit date:2001-04-19
Release date:2001-10-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
Biochemistry, 40, 2001
1JYE
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BU of 1jye by Molmil
Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution
Descriptor: GLYCEROL, Lactose Operon Repressor
Authors:Bell, C.E, Barry, J, Matthews, K.S, Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1JWL
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BU of 1jwl by Molmil
Structure of the Dimeric lac Repressor/Operator O1/ONPF Complex
Descriptor: 2-nitrophenyl beta-D-fucopyranoside, 5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', ...
Authors:Bell, C.E, Lewis, M.
Deposit date:2001-09-04
Release date:2001-10-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic analysis of Lac repressor bound to natural operator O1.
J.Mol.Biol., 312, 2001
1JYF
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BU of 1jyf by Molmil
Structure of the Dimeric Lac Repressor with an 11-residue C-terminal Deletion.
Descriptor: GLYCEROL, Lactose Operon Repressor
Authors:Bell, C.E, Barry, J, Matthews, K.S, Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1KCA
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BU of 1kca by Molmil
Crystal Structure of the lambda Repressor C-terminal Domain Octamer
Descriptor: REPRESSOR PROTEIN CI
Authors:Bell, C.E, Lewis, M.
Deposit date:2001-11-07
Release date:2001-12-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structure of the lambda repressor C-terminal domain octamer.
J.Mol.Biol., 314, 2001
1M3W
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BU of 1m3w by Molmil
Crystal Structure of a Molecular Maquette Scaffold
Descriptor: H10H24, MERCURY (II) ION
Authors:Huang, S.S, Gibney, B.R, Stayrook, S.E, Dutton, P.L, Lewis, M.
Deposit date:2002-07-01
Release date:2003-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray Structure of a Maquette Scaffold
J.Mol.Biol., 326, 2003
2YNO
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BU of 2yno by Molmil
yeast betaprime COP 1-304H6
Descriptor: COATOMER SUBUNIT BETA', POLY ALA
Authors:Jackson, L.P, Lewis, M, Kent, H.M, Edeling, M.A, Evans, P.R, Duden, R, Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
2YNP
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BU of 2ynp by Molmil
yeast betaprime COP 1-604 with KTKTN motif
Descriptor: COATOMER SUBUNIT BETA', KTKTN MOTIF
Authors:Jackson, L.P, Lewis, M, Kent, H.M, Edeling, M.A, Evans, P.R, Duden, R, Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.962 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
2YNN
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BU of 2ynn by Molmil
yeast betaprime COP 1-304 with KTKTN motif
Descriptor: COATOMER SUBUNIT BETA', KTKTN MOTIF, SULFATE ION
Authors:Jackson, L.P, Lewis, M, Kent, H.M, Edeling, M.A, Evans, P.R, Duden, R, Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
1AAQ
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BU of 1aaq by Molmil
HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
Descriptor: HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate
Authors:Lewis, M.
Deposit date:1992-04-13
Release date:1994-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31, 1992
4BV4
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BU of 4bv4 by Molmil
Structure and allostery in Toll-Spatzle recognition
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN SPAETZLE C-106, PROTEIN TOLL, ...
Authors:Lewis, M.F, Arnot, C.J, Beeston, H, McCoy, A, Ashcroft, A.E, Gay, N.J, Gangloff, M.
Deposit date:2013-06-24
Release date:2013-12-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
3MO7
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BU of 3mo7 by Molmil
Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP
Descriptor: 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, Uridine 5'-monophosphate synthase
Authors:Liu, Y, Kotra, L.P, Pai, E.F.
Deposit date:2010-04-22
Release date:2011-04-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
J.Med.Chem., 54, 2011

 

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