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Crystal structure of chicken LGP2 with 5'p 12-mer dsRNA at 3.6 A resolution
Descriptor:	LGP2, RNA (5'-R(PGPGPUPAPGPCPGPCPUPAPCPC)-3'), ZINC ION
Authors:	Cusack, S, Uchikawa, E, Lethier, M.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (3.58 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:	Cusack, S, Lethier, M.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6FLN

Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains
Descriptor:	E3 ubiquitin/ISG15 ligase TRIM25
Authors:	Cusack, S, Lethier, M.
Deposit date:	2018-01-26
Release date:	2018-05-23
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9, 2018

8AZA

Structure of RIP2K dimer bound to the XIAP BIR2 domain
Descriptor:	E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:	Pellegrini, E, Cusack, S.
Deposit date:	2022-09-05
Release date:	2022-10-26
Last modified:	2023-09-20
Method:	ELECTRON MICROSCOPY (3.15 Å)
Cite:	Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Life Sci Alliance, 6, 2023

4D64

Structure of porin Omp-Pst1 from P. stuartii; the crystallographic symmetry generates a dimer of trimers.
Descriptor:	CALCIUM ION, PORIN 1
Authors:	Nasrallah, C, Colletier, J.P.
Deposit date:	2014-11-08
Release date:	2016-03-09
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Porin self-association enables cell-to-cell contact inProvidencia stuartiifloating communities. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

4D65

Structure of porin Omp-Pst2 from P. stuartii; the asymmetric unit contains a dimer of trimers.
Descriptor:	3-HYDROXY-TETRADECANOIC ACID, LAURYL DIMETHYLAMINE-N-OXIDE, MYRISTIC ACID, ...
Authors:	Nasrallah, C, Colletier, J.P.
Deposit date:	2014-11-08
Release date:	2016-03-09
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Porin self-association enables cell-to-cell contact inProvidencia stuartiifloating communities. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

5NXN

Structure of a L5-deletion mutant of Providencia stuartii Omp-Pst1
Descriptor:	CALCIUM ION, Porin 1
Authors:	El Khatib, M, Colletier, J.P.
Deposit date:	2017-05-10
Release date:	2018-02-21
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.12 Å)
Cite:	Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018

5N9I

STRUCTURE OF 206-GVVTSE-211, THE STERIC ZIPPER THAT SUPPORTS THE SELF-ASSOCIATION OF P. STUARTII OMP-PST1 INTO DIMERS OF TRIMERS
Descriptor:	Porin 1
Authors:	Colletier, J.P, Nasrallah, C.
Deposit date:	2017-02-24
Release date:	2018-02-21
Last modified:	2018-03-14
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018

5N9H

STRUCTURE OF 283-LGNY-286, THE STERIC ZIPPER THAT SUPPORTS THE SELF-ASSOCIATION OF P. STUARTII OMP-PST2 INTO DIMERS OF TRIMERS
Descriptor:	Porin, SULFATE ION
Authors:	Nasrallah, C, Colletier, J.P.
Deposit date:	2017-02-24
Release date:	2018-02-21
Last modified:	2018-03-14
Method:	X-RAY DIFFRACTION (0.997 Å)
Cite:	Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018

5NXU

Complex structure with maltose of Providencia stuartii Omp-Pst1 porin
Descriptor:	CALCIUM ION, LAURYL DIMETHYLAMINE-N-OXIDE, Porin 1, ...
Authors:	Colletier, J.P, Nasrallah, C.
Deposit date:	2017-05-10
Release date:	2018-02-21
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018

5NXR

Trimeric structure of Omp-Pst1, the major porin from Providencia stuartii
Descriptor:	CALCIUM ION, CHLORIDE ION, LAURYL DIMETHYLAMINE-N-OXIDE, ...
Authors:	Colletier, J.P, Nasrallah, C.
Deposit date:	2017-05-10
Release date:	2018-02-21
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018

4FNG

The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina
Descriptor:	E3 alpha-esterase-7 caboxylesterase
Authors:	Jackson, C.J, Liu, J.-W, Carr, P.D, Younis, F, Pandey, G, Coppin, C, Meirelles, T, Ollis, D.L, Tawfik, D.S, Weik, M, Oakeshott, J.G.
Deposit date:	2012-06-19
Release date:	2013-06-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance. Proc.Natl.Acad.Sci.USA, 110, 2013

4FNM

The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina
Descriptor:	DIETHYL HYDROGEN PHOSPHATE, E3 alpha-esterase-7 carboxylesterase
Authors:	Jackson, C.J, Liu, J.-W, Carr, P.D, Younis, F, Pandey, G, Coppin, C, Meirelles, T, Ollis, D.L, Tawfik, D.S, Weik, M, Oakeshott, J.G.
Deposit date:	2012-06-20
Release date:	2013-12-04
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.804 Å)
Cite:	Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance. Proc.Natl.Acad.Sci.USA, 110, 2013

5IKX

Crystal structure of the alpha-esterase-7 carboxyl esterase (dimer), E3, from Lucilia cuprina
Descriptor:	Carboxylic ester hydrolase
Authors:	Jackson, C, Fraser, N.
Deposit date:	2016-03-04
Release date:	2016-06-22
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability. J.Mol.Biol., 428, 2016

5JCH

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-15
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.95 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JBG

Crystal structure of chicken LGP2 with 5'ppp 26-mer hairpin RNA with 3' GG overhang and ADP-AlF4-Mg2+ at 2.0 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, LGP2, MAGNESIUM ION, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JC3

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-14
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JCF

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-15
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JC7

Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-14
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JAJ

Structure of chicken LGP2 witha 5'p 10-mer dsRNA and ADP-AlF4-Mg.
Descriptor:	1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, LGP2, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-12
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JB2

Crystal structure of chicken LGP2 with 5'ppp 10-mer dsRNA and ADP-AlF4-Mg2+ at 2.2 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, LGP2, MAGNESIUM ION, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5NT1

Complex of influenza A NS1 effector domain with TRIM25 coiled coil
Descriptor:	E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:	Koliopoulos, M.G, Rittinger, K.
Deposit date:	2017-04-27
Release date:	2018-05-16
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.82 Å)
Cite:	Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9, 2018

5NT2

Complex of influenza A NS1 with TRIM25 coiled coil domain
Descriptor:	E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:	Koliopoulos, M.G, Rittinger, K.
Deposit date:	2017-04-27
Release date:	2018-05-23
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (4.259 Å)
Cite:	Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9, 2018

6EVJ

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
Descriptor:	Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D((GDM))-R(PAPAPU)-3'), ...
Authors:	Pflug, A, Cusack, S.
Deposit date:	2017-11-01
Release date:	2017-12-13
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.9 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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