Author results

2SRC
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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
Descriptor:TYROSINE-PROTEIN KINASE SRC, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Xu, W., Doshi, A., Lei, M., Eck, M.J., Harrison, S.C.
Deposit date:1998-12-29
Release date:1999-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
1F3M
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CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA, IODIDE ION
Authors:Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C.
Deposit date:2000-06-05
Release date:2000-06-29
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
1QZG
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
Descriptor:telomeric single-stranded DNA, Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE
Authors:Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1QZH
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
Descriptor:telomeric single-stranded DNA, Protection of telomeres protein 1
Authors:Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1XJV
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CRYSTAL STRUCTURE OF HUMAN POT1 BOUND TO TELOMERIC SINGLE-STRANDED DNA (TTAGGGTTAG)
Descriptor:hT10 d(TTAGGGTTAG), Protection of telomeres 1
Authors:Lei, M., Podell, E.R., Cech, T.R.
Deposit date:2004-09-25
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Nat.Struct.Mol.Biol., 11, 2004
1YHV
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH TWO POINT MUTATIONS (K299R, T423E)
Descriptor:Serine/threonine-protein kinase PAK 1
Authors:Lei, M., Robinson, M.A., Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
1YHW
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH ONE POINT MUTATIONS (K299R)
Descriptor:Serine/threonine-protein kinase PAK 1
Authors:Lei, M., Robinson, M.A., Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
2HKO
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CRYSTAL STRUCTURE OF LSD1
Descriptor:Lysine-specific histone demethylase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Chen, Y., Yang, Y.T., Wang, F., Yanane, K., Zhang, Y., Lei, M.
Deposit date:2006-07-05
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HY8
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PAK1 COMPLEX WITH ST2001
Descriptor:Serine/threonine-protein kinase PAK 1, (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2006-08-04
Release date:2006-11-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine
To be Published
2I46
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CRYSTAL STRUCTURE OF HUMAN TPP1
Descriptor:Adrenocortical dysplasia protein homolog
Authors:Wang, F., Podell, E.R., Zaug, A.J., Yang, Y.T., Baciu, P., Else, T., Hammer, G.D., Cech, T.R., Lei, M.
Deposit date:2006-08-21
Release date:2006-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
2RGX
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CRYSTAL STRUCTURE OF ADENYLATE KINASE FROM AQUIFEX AEOLICUS IN COMPLEX WITH AP5A
Descriptor:Adenylate kinase, ZINC ION, BIS(ADENOSINE)-5'-PENTAPHOSPHATE
Authors:Thai, V., Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M.A., Petsko, G.A., Kern, D.
Deposit date:2007-10-05
Release date:2007-12-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Intrinsic motions along an enzymatic reaction trajectory.
Nature, 450, 2007
2RH5
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STRUCTURE OF APO ADENYLATE KINASE FROM AQUIFEX AEOLICUS
Descriptor:Adenylate kinase
Authors:Thai, V., Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M.A., Petsko, G.A., Kern, D.
Deposit date:2007-10-05
Release date:2007-12-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Intrinsic motions along an enzymatic reaction trajectory.
Nature, 450, 2007
3BQO
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CRYSTAL STRUCTURE OF TRF1 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 1, TERF1-interacting nuclear factor 2
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2007-12-20
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BU8
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 2, TERF1-interacting nuclear factor 2
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2008-01-02
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BUA
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND APOLLO PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 2, DNA cross-link repair 1B protein
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2008-01-02
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3CRT
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
Deposit date:2008-04-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
3CRU
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
Deposit date:2008-04-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
3D0Z
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STRUCTURAL CHARCATERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M.
Deposit date:2008-05-02
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
3DBQ
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN
Descriptor:Dual specificity protein kinase TTK
Authors:Wang, W., Yang, Y.T., Gao, Y.F., Zhu, S.C., Wang, F., Old, W., Xu, Q.B., Resing, K., Ahn, N., Lei, M., Liu, X.D.
Deposit date:2008-06-02
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Mechanistic Insights into Mps1 Kinase Activation
J.CELL.MOL.MED., 13, 2008
3K6G
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CRYSTAL STRUCTURE OF RAP1 AND TRF2 COMPLEX
Descriptor:Telomeric repeat-binding factor 2-interacting protein 1, Telomeric repeat-binding factor 2
Authors:Chen, Y., Rai, R., Yang, Y.T., Zheng, H., Chang, S., Lei, M.
Deposit date:2009-10-08
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
3KEY
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CRYSTAL STRUCTURE OF S. CEREVISIAE STN1 C-TERMINAL
Descriptor:Protein STN1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3KF6
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CRYSTAL STRUCTURE OF S. POMBE STN1-TEN1 COMPLEX
Descriptor:Protein stn1, Protein ten1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3KF8
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CRYSTAL STRUCTURE OF C. TROPICALIS STN1-TEN1 COMPLEX
Descriptor:Protein stn1, Protein ten1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3L82
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X-RAY CRYSTAL STRUCTURE OF TRF1 AND FBX4 COMPLEX
Descriptor:Telomeric repeat-binding factor 1, F-box only protein 4
Authors:Zeng, Z.X., Wang, W., Yang, Y.T., Chen, Y., Yang, X.M., Diehl, J.A., Liu, X.D., Lei, M.
Deposit date:2009-12-29
Release date:2010-03-09
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
3NBH
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CRYSTAL STRUCTURE OF HUMAN RMI1C-RMI2 COMPLEX
Descriptor:RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2
Authors:Wang, F., Yang, Y., Singh, T.R., Busygina, V., Guo, R., Wan, K., Wang, W., Sung, P., Meetei, A.R., Lei, M.
Deposit date:2010-06-03
Release date:2010-09-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010