Author results

6OGK
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6OGJ
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6MLC
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PHD6 DOMAIN OF MLL3 IN COMPLEX WITH HISTONE H4
Descriptor:Histone-lysine N-methyltransferase 2C, Histone H4, ZINC ION, ...
Authors:Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
6K0B
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CRYO-EM STRUCTURE OF ARCHAEAL RIBONUCLEASE P WITH MATURE TRNA
Descriptor:Ribonuclease P protein component 2, Ribonuclease P protein component 3, Ribonuclease P protein component 1, ...
Authors:Wan, F., Lan, P., Wu, J., Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
6K0A
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CRYO-EM STRUCTURE OF AN ARCHAEAL RIBONUCLEASE P
Descriptor:Ribonuclease P protein component 2, Ribonuclease P protein component 3, Ribonuclease P protein component 1, ...
Authors:Wan, F., Lan, P., Wu, J., Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
6J99
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CRYO-EM STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH AN H2B-MONOUBIQUITINATED NUCLEOSOME
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Yao, T., Huang, J.
Deposit date:2019-01-22
Release date:2019-02-27
Last modified:2019-04-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome.
Cell Res., 29, 2019
6J67
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CRYSTAL STRUCTURE OF THE COMPOUND 34 IN A COMPLEX WITH TRF2
Descriptor:Telomeric repeat-binding factor 2, 3FB-PHE-B8R-LEU-5XU-PRO
Authors:Chen, Y., Yang, Y., Lei, M.
Deposit date:2019-01-14
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.
ACS Med Chem Lett, 9, 2018
6J08
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CRYSTAL STRUCTURE OF HUMAN MAJIN AND TERB2
Descriptor:Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2
Authors:Wang, Y., Chen, Y., Wu, J., Huang, C., Lei, M.
Deposit date:2018-12-21
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
6J07
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CRYSTAL STRUCTURE OF HUMAN TERB2 AND TERB1
Descriptor:Telomere repeats-binding bouquet formation protein 2, Telomere repeats-binding bouquet formation protein 1, ZINC ION
Authors:Wang, Y., Chen, Y., Wu, J., Huang, C., Lei, M.
Deposit date:2018-12-21
Release date:2019-02-27
Method:X-RAY DIFFRACTION (3.298 Å)
Cite:The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
6CNQ
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNP
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CRYSTAL STRUCTURE OF MBD2 COMPLEX WITH METHYLATED CPG ISLAND
Descriptor:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3'), CALCIUM ION, ...
Authors:Xu, C., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CEV
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
Descriptor:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
Authors:Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 2019
6CEU
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
Descriptor:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
Authors:Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 2019
6CCG
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
Descriptor:Methyl-CpG-binding domain protein 3, DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-07
Release date:2018-05-09
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 2019
6CC8
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
Descriptor:Methyl-CpG-binding domain protein 3, methylated CpG DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-06
Release date:2018-04-04
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 2019
6C1V
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MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1U
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MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1T
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MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1A
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ...
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-04
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6BPH
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CRYSTAL STRUCTURE OF THE CHROMODOMAIN OF RBBP1
Descriptor:AT-rich interactive domain-containing protein 4A, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-11-23
Release date:2017-12-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of chromo barrel domain of RBBP1.
Biochem. Biophys. Res. Commun., 496, 2018
6ASD
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ZINC FINGER REGION OF HUMAN TET1 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase TET1, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6ASB
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CXXC AND PHD-TYPE ZINC FINGER REGIONS OF FBXL19 IN COMPLEX WITH DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), F-box/LRR-repeat protein 19, ZINC ION
Authors:Liu, K., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6AHV
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CRYSTAL STRUCTURE OF HUMAN RPP40
Descriptor:Ribonuclease P protein subunit p40
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHU
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P WITH MATURE TRNA
Descriptor:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHR
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P
Descriptor:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018