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4WUK
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BU of 4wuk by Molmil
Crystal structure of apo CH65 Fab
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CH65 heavy chain, CH65 light chain
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2014-11-01
Release date:2015-02-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the apo anti-influenza CH65 Fab.
Acta Crystallogr.,Sect.F, 71, 2015
4ZCJ
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BU of 4zcj by Molmil
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA1 Cys30, HA2 Cys47 mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2015-04-16
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer.
J.Virol., 89, 2015
7S13
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BU of 7s13 by Molmil
Crystal structure of Fab in complex with mouse CD96 dimer
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, ...
Authors:Lee, P.S, Barman, I, Strop, P.
Deposit date:2021-08-31
Release date:2021-10-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Antibody blockade of CD96 by distinct molecular mechanisms.
Mabs, 13, 2021
7S11
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BU of 7s11 by Molmil
Crystal structure of Fab in complex with mouse CD96 monomer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
Authors:Lee, P.S, Chau, B, Strop, P.
Deposit date:2021-08-31
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Antibody blockade of CD96 by distinct molecular mechanisms.
Mabs, 13, 2021
7SU1
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BU of 7su1 by Molmil
Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ...
Authors:Lee, P.S, Chau, B, Strop, P.
Deposit date:2021-11-15
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Improved therapeutic index of an acidic pH-selective antibody.
Mabs, 14, 2022
7SU0
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BU of 7su0 by Molmil
Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Cytotoxic T-lymphocyte protein 4, ...
Authors:Lee, P.S, Chau, B, Strop, P.
Deposit date:2021-11-15
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Improved therapeutic index of an acidic pH-selective antibody.
Mabs, 14, 2022
4GMS
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BU of 4gms by Molmil
Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ...
Authors:Lee, P.S, Ekiert, D.C, Wilson, I.A.
Deposit date:2012-08-16
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GMT
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BU of 4gmt by Molmil
Crystal structure of heterosubtypic Fab S139/1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ...
Authors:Lee, P.S, Ekiert, D.C, Wilson, I.A.
Deposit date:2012-08-16
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4O58
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BU of 4o58 by Molmil
Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7501 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5N
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BU of 4o5n by Molmil
Crystal structure of A/Victoria/361/2011 (H3N2) influenza virus hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5L
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BU of 4o5l by Molmil
Crystal structure of broadly neutralizing antibody F045-092
Descriptor: Fab F045-092 heavy chain, Fab F045-092 light chain, PHOSPHATE ION
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5045 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5I
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BU of 4o5i by Molmil
Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab F045-092 heavy chain, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (6.501 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
5KUX
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BU of 5kux by Molmil
Designed influenza hemagglutinin binding protein HSB.2
Descriptor: Designed influenza inhibitor protein HSB.2
Authors:Lee, P.S, Bernard, S.M, Wilson, I.A.
Deposit date:2016-07-13
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
7S7I
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BU of 7s7i by Molmil
Crystal structure of Fab in complex with MICA alpha3 domain
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ...
Authors:Lee, P.S, Strop, P.
Deposit date:2021-09-16
Release date:2022-10-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting.
Anal.Chem., 95, 2023
4M5Y
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BU of 4m5y by Molmil
Crystal structure of broadly neutralizing Fab 5J8
Descriptor: DI(HYDROXYETHYL)ETHER, Fab 5J8 heavy chain, Fab 5J8 light chain, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-08-08
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
4NM8
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BU of 4nm8 by Molmil
Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8043, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.0041 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NM4
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BU of 4nm4 by Molmil
Crystal structure of broadly neutralizing antibody CR8043
Descriptor: Antibody CR8043, Heavy Chain, Light Chain, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
8SZY
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BU of 8szy by Molmil
Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BMS-986207 Fab Heavy Chain, BMS-986207 light chain, ...
Authors:Diong, S.J, Lee, P.S.
Deposit date:2023-05-30
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT.
Mabs, 15, 2023
5IC6
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BU of 5ic6 by Molmil
Crystal structure of caspase-7 DEVE peptide complex
Descriptor: Caspase-7 subunit p11, Caspase-7 subunit p20, DEVE peptide
Authors:Seaman, J.E, Julien, O, Lee, P.S, Rettenmaier, T.J, Thomsen, N.D, Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
5IC4
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BU of 5ic4 by Molmil
Crystal structure of caspase-3 DEVE peptide complex
Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, DEVE peptide
Authors:Seaman, J.E, Julien, O, Lee, P.S, Rettenmaier, T.J, Thomsen, N.D, Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
2O8K
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BU of 2o8k by Molmil
NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element
Descriptor: 5'-D(*GP*AP*AP*AP*CP*GP*TP*GP*CP*CP*AP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*GP*CP*AP*CP*GP*TP*TP*TP*C)-3', RNA polymerase sigma factor RpoN
Authors:Doucleff, M, Pelton, J.G, Lee, P.S, Wemmer, D.E.
Deposit date:2006-12-12
Release date:2007-07-17
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structural basis of DNA recognition by the alternative sigma-factor, sigma54.
J.Mol.Biol., 369, 2007
2O9L
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BU of 2o9l by Molmil
AMBER refined NMR Structure of the Sigma-54 RpoN Domain Bound to the-24 Promoter Element
Descriptor: 5'-D(*GP*AP*AP*AP*CP*GP*TP*GP*CP*CP*AP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*GP*CP*AP*CP*GP*TP*TP*TP*C)-3', RNA polymerase sigma factor RpoN
Authors:Doucleff, M, Pelton, J.G, Lee, P.S, Wemmer, D.E.
Deposit date:2006-12-13
Release date:2007-07-17
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structural basis of DNA recognition by the alternative sigma-factor, sigma54.
J.Mol.Biol., 369, 2007
5WKZ
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BU of 5wkz by Molmil
VH1-69 germline antibody predicted from CR6261
Descriptor: Immunoglobulin heavy variable 1-69D,IgG H chain, Lambda-chain (AA -20 to 215), SULFATE ION
Authors:Lang, S, Lee, P.S.
Deposit date:2017-07-25
Release date:2018-08-01
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem
To Be Published
4M5Z
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BU of 4m5z by Molmil
Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit
Descriptor: Fab 5J8 heavy chain, Fab 5J8 light chain, Hemagglutinin HA1 chain
Authors:Hong, M, Lee, P.S, Wilson, I.A.
Deposit date:2013-08-08
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
6MAE
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BU of 6mae by Molmil
CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide
Descriptor: (2R)-3-{(5S)-3-[4-(cyclopropylethynyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)propanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION
Authors:Shu, W.
Deposit date:2018-08-27
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.
J. Med. Chem., 61, 2018

 

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