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1LBE
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BU of 1lbe by Molmil
APLYSIA ADP RIBOSYL CYCLASE
Descriptor: ADP RIBOSYL CYCLASE
Authors:Prasad, G.S, Mcree, D.E, Stura, E.A, Levitt, D.G, Lee, H.C, Stout, C.D.
Deposit date:1996-09-18
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38.
Nat.Struct.Biol., 3, 1996
1YH3
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BU of 1yh3 by Molmil
Crystal structure of human CD38 extracellular domain
Descriptor: ADP-ribosyl cyclase 1
Authors:Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
Deposit date:2005-01-06
Release date:2005-09-27
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of human CD38 extracellular domain.
Structure, 13, 2005
3DZH
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BU of 3dzh by Molmil
Crystal structure of human CD38 extracellular domain, GTP complex
Descriptor: ADP-ribosyl cyclase 1, GUANOSINE-5'-TRIPHOSPHATE
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZJ
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BU of 3dzj by Molmil
Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex
Descriptor: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZK
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Crystal structure of human CD38 extracellular domain, NMN complex
Descriptor: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZF
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BU of 3dzf by Molmil
Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate
Descriptor: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZI
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Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex
Descriptor: 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside, ADP-ribosyl cyclase 1, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, ...
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZG
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BU of 3dzg by Molmil
Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex
Descriptor: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1, NICOTINAMIDE
Authors:Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3F6Y
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BU of 3f6y by Molmil
Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
Descriptor: ADP-ribosyl cyclase 1, CALCIUM ION
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Lam, C.M.C, Lee, H.C, Hao, Q.
Deposit date:2008-11-07
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
Biochemistry, 47, 2008
3ZWN
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BU of 3zwn by Molmil
Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR
Descriptor: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWW
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BU of 3zww by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWM
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BU of 3zwm by Molmil
Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR
Descriptor: ADP-RIBOSYL CYLCASE, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWP
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BU of 3zwp by Molmil
Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, GLYCEROL, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWV
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BU of 3zwv by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
Descriptor: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase.
J. Mol. Biol., 415, 2012
3ZWY
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BU of 3zwy by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose
Descriptor: (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
3ZWO
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BU of 3zwo by Molmil
Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate
Descriptor: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, GUANOSINE DIPHOSPHATE RIBOSE
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWX
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BU of 3zwx by Molmil
Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose
Descriptor: ADP-RIBOSYL CYCLASE, CHLORIDE ION, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
5BNF
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BU of 5bnf by Molmil
Apo structure of porcine CD38
Descriptor: Uncharacterized protein
Authors:Ting, K.Y, Leung, C.P.F, Graeff, R.M, Lee, H.C, Hao, Q, Kotaka, M.
Deposit date:2015-05-26
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity.
Protein Sci., 25, 2016
5BNI
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BU of 5bni by Molmil
Porcine CD38 complexed with complexed with a covalent intermediate, ribo-F-ribose-5'-phosphate
Descriptor: Uncharacterized protein, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Ting, K.Y, Leung, C.F.P, Graeff, R.M, Lee, H.C, Hao, Q, Kotaka, M.
Deposit date:2015-05-26
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity.
Protein Sci., 25, 2016
4F46
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BU of 4f46 by Molmil
Crystal structure of wild type human CD38 in complex with NAADP and ADPRP
Descriptor: ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5S)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Zhang, H, Lee, H.C, Hao, Q.
Deposit date:2012-05-10
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structures of Human CD38 in Complex with NAADP and ADPRP
MESSENGER, 2, 2013
4F45
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BU of 4f45 by Molmil
Crystal structure of human CD38 E226Q mutant in complex with NAADP
Descriptor: ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate
Authors:Zhang, H, Lee, H.C, Hao, Q.
Deposit date:2012-05-10
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human CD38 in Complex with NAADP and ADPRP
MESSENGER, 2, 2013
3OFS
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BU of 3ofs by Molmil
Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography
Descriptor: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Zhang, H, Lee, H.C, Hao, Q.
Deposit date:2010-08-16
Release date:2010-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
3ROP
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BU of 3rop by Molmil
Crystal structure of human CD38 in complex with compound CZ-50b
Descriptor: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-ribofuranose, ADP-ribosyl cyclase 1, NICOTINAMIDE
Authors:Zhang, H, Lee, H.C, Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3I9N
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BU of 3i9n by Molmil
Crystal structure of human CD38 complexed with an analog ribo-2'F-ADP ribose
Descriptor: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9K
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BU of 3i9k by Molmil
Crystal structure of ADP ribosyl cyclase complexed with substrate NAD
Descriptor: ADP-ribosyl cyclase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q, Graeff, R, Kriksunov, I.A, Jiang, H, Zhang, B, Oppenheimer, N, Lin, H, Potter, B.V.L, Lee, H.C, Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009

 

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