1FNF
 
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1CD8
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1TEN
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1BAF
 | | 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL-SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN | | Descriptor: | IGG1-KAPPA AN02 FAB (HEAVY CHAIN), IGG1-KAPPA AN02 FAB (LIGHT CHAIN), N-(2-AMINO-ETHYL)-4,6-DINITRO-N'-(2,2,6,6-TETRAMETHYL-1-OXY-PIPERIDIN-4-YL)-BENZENE-1,3-DIAMINE | | Authors: | Leahy, D.J, Brunger, A.T, Fox, R.O, Hynes, T.R. | | Deposit date: | 1992-01-16 | | Release date: | 1994-01-31 | | Last modified: | 2013-09-18 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten.
J.Mol.Biol., 221, 1991
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1ZOO
 | | CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | | Descriptor: | CHLORIDE ION, LEUKOCYTE ADHESION GLYCOPROTEIN, MAGNESIUM ION | | Authors: | Leahy, D.J, Qu, A. | | Deposit date: | 1996-06-21 | | Release date: | 1996-12-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
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1ZOP
 | | CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | | Descriptor: | CHLORIDE ION, I-DOMAIN FRAGMENT OF LFA-1, MANGANESE (II) ION | | Authors: | Leahy, D.J, Qu, A. | | Deposit date: | 1996-06-21 | | Release date: | 1996-12-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
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1ZON
 | | CD11A I-DOMAIN WITHOUT BOUND CATION | | Descriptor: | LEUKOCYTE ADHESION GLYCOPROTEIN | | Authors: | Leahy, D.J, Qu, A. | | Deposit date: | 1996-06-20 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
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1LFA
 | | CD11A I-DOMAIN WITH BOUND MN++ | | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | | Authors: | Leahy, D.J, Qu, A. | | Deposit date: | 1995-09-08 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proc.Natl.Acad.Sci.USA, 92, 1995
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1M6B
 | | Structure of the HER3 (ERBB3) Extracellular Domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor protein-tyrosine kinase erbB-3, ... | | Authors: | Leahy, D.J, Cho, H.-S. | | Deposit date: | 2002-07-15 | | Release date: | 2002-08-02 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the extracellular region of HER3 reveals an interdomain tether.
Science, 297, 2002
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1DDV
 | | CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE | | Descriptor: | GLGF-DOMAIN PROTEIN HOMER, METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 | | Authors: | Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J. | | Deposit date: | 1999-11-11 | | Release date: | 2000-05-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
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1DDW
 | | HOMER EVH1 DOMAIN UNLIGANDED | | Descriptor: | GLGF-DOMAIN PROTEIN HOMER | | Authors: | Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J. | | Deposit date: | 1999-11-11 | | Release date: | 2000-05-10 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
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6JFV
 | | The crystal structure of 2B-2B complex from keratins 5 and 14 (C367A mutant of K14) | | Descriptor: | Keratin, type I cytoskeletal 14, type II cytoskeletal 5 | | Authors: | Kim, M.S, Lee, C.H, Coulombe, P.A, Leahy, D.J. | | Deposit date: | 2019-02-12 | | Release date: | 2020-01-22 | | Last modified: | 2022-03-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.
Structure, 28, 2020
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1AT0
 | | 17-kDA fragment of hedgehog C-terminal autoprocessing domain | | Descriptor: | 17-HEDGEHOG | | Authors: | Hall, T.M.T, Porter, J.A, Young, K.E, Koonin, E.V, Beachy, P.A, Leahy, D.J. | | Deposit date: | 1997-08-15 | | Release date: | 1997-11-12 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Cell(Cambridge,Mass.), 91, 1997
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2A90
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2AHX
 | | Crystal structure of ErbB4/HER4 extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4, SULFATE ION, ... | | Authors: | Bouyain, S, Longo, P.A, Li, S, Ferguson, K.M, Leahy, D.J. | | Deposit date: | 2005-07-28 | | Release date: | 2005-09-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA, 102, 2005
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4PFJ
 | | The structure of bi-acetylated SAHH | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | | Deposit date: | 2014-04-29 | | Release date: | 2014-10-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
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4PGF
 | | The structure of mono-acetylated SAHH | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | | Deposit date: | 2014-05-01 | | Release date: | 2014-10-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
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3BXL
 | | Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex | | Descriptor: | CALCIUM ION, Calmodulin, SULFATE ION, ... | | Authors: | Mori, M.X, Vander Kooi, C.W, Leahy, D.J, Yue, D.T. | | Deposit date: | 2008-01-14 | | Release date: | 2008-03-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin
To be Published
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3BXK
 | | Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex | | Descriptor: | CALCIUM ION, Calmodulin, SULFATE ION, ... | | Authors: | Mori, M.X, Vander Kooi, C.W, Leahy, D.J, Yue, D.T. | | Deposit date: | 2008-01-14 | | Release date: | 2008-03-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex
To be Published
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3D1M
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1S78
 | | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, ... | | Authors: | Franklin, M.C, Carey, K.D, Vajdos, F.F, Leahy, D.J, de Vos, A.M, Sliwkowski, M.X. | | Deposit date: | 2004-01-29 | | Release date: | 2004-04-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004
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2OGB
 | | Crystal structure of the C-terminal domain of mouse Nrdp1 | | Descriptor: | GLYCEROL, RING finger protein 41, THIOCYANATE ION | | Authors: | Bouyain, S, Leahy, D.J. | | Deposit date: | 2007-01-05 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3.
Protein Sci., 16, 2007
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2ORX
 | | Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | | Descriptor: | Neuropilin-1 | | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | | Deposit date: | 2007-02-05 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ORZ
 | | Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | | Descriptor: | Neuropilin-1, Tuftsin | | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | | Deposit date: | 2007-02-05 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2IBB
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