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1XYA
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, HYDROXIDE ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYB
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, D-GLUCOSE IN LINEAR FORM, MAGNESIUM ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYC
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, 3-O-METHYLFRUCTOSE IN LINEAR FORM, MAGNESIUM ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1TMK
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YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)
Descriptor:THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, SULFATE ION
Authors:Lavie, A., Schlichting, I.
Deposit date:1997-06-12
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
2TMK
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YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
Descriptor:THYMIDYLATE KINASE, SULFATE ION, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE
Authors:Lavie, A., Schlichting, I.
Deposit date:1997-06-12
Release date:1998-06-17
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3TMK
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CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION
Descriptor:THYMIDYLATE KINASE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE
Authors:Lavie, A., Schlichting, I., Konrad, M., Goody, R.S., Brundiers, R., Reinstein, J.
Deposit date:1998-01-26
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry, 37, 1998
4TMK
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COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A
Descriptor:PROTEIN (THYMIDYLATE KINASE), P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE
Authors:Lavie, A., Ostermann, N., Schlichting, I.
Deposit date:1998-08-31
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
5TMP
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COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR AZTP5A
Descriptor:PROTEIN (THYMIDYLATE KINASE), P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE
Authors:Lavie, A., Ostermann, N., Schlichting, I.
Deposit date:1998-09-01
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
3QEN
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S74E DCK IN COMPLEX WITH 5-BROMODEOXYCYTIDINE AND UDP
Descriptor:Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 5-bromo-2'-deoxycytidine
Authors:Lavie, A., Hazra, S.
Deposit date:2011-01-20
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEO
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S74E-R104M-D133A DCK VARIANT IN COMPLEX WITH L-DEOXYTHYMIDINE AND UDP
Descriptor:Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, L-deoxythymidine
Authors:Lavie, A., Hazra, S.
Deposit date:2011-01-20
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
2RCZ
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STRUCTURE OF THE SECOND PDZ DOMAIN OF ZO-1
Descriptor:Tight junction protein ZO-1
Authors:Lavie, A., Lye, M.F.
Deposit date:2007-09-20
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
J.Biol.Chem., 282, 2007
3MTR
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CRYSTAL STRUCTURE OF THE IG5-FN1 TANDEM OF HUMAN NCAM
Descriptor:Neural cell adhesion molecule 1, SULFATE ION
Authors:Lavie, A., Foley, D.A.
Deposit date:2010-04-30
Release date:2010-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites
J.Biol.Chem., 285, 2010
2GYI
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DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1994-09-01
Release date:1995-07-10
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex
Biochemistry, 34, 1995
1XYL
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THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, HYDROXIDE ION
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
1XYM
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THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor:XYLOSE ISOMERASE, D-GLUCOSE IN LINEAR FORM, MAGNESIUM ION, ...
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
1E98
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WILD TYPE HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
Descriptor:THYMIDYLATE KINASE, ADENOSINE-5'-DIPHOSPHATE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E99
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
Descriptor:THYMIDYLATE KINASE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reinstein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9A
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR AZTP5A
Descriptor:THYMIDYLATE KINASE, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, MAGNESIUM ION
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9B
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND APPNP
Descriptor:THYMIDYLATE KINASE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9C
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MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND APPNP
Descriptor:THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9D
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MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH AZTMP AND ADP
Descriptor:THYMIDYLATE KINASE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9E
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MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH DTMP AND ADP
Descriptor:THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-11
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9F
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MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP
Descriptor:THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reinstein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-11
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1P6X
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND SO4
Descriptor:Thymidine kinase, SULFATE ION, THYMIDINE
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P72
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CRYSTAL STRUCTURE OF EHV4-TK COMPLEXED WITH THY AND ADP
Descriptor:Thymidine kinase, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Deposit date:2003-04-30
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003