Author results

3NYV
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH NON-SPECIFIC INHIBITOR WHI-P180
Descriptor:Calmodulin-domain protein kinase 1, 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-07-15
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Binding modes of non-specific inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from T. gondii and C. parvum
To be Published
3SX9
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR, RM-1-132
Descriptor:Calmodulin-domain protein kinase 1, 3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Larson, E.T., Merritt, E.A.
Deposit date:2011-07-14
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J.Med.Chem., 55, 2012
3SXF
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR, RM-1-89
Descriptor:Calmodulin-domain protein kinase 1, 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, DIMETHYL SULFOXIDE, ...
Authors:Larson, E.T., Merritt, E.A.
Deposit date:2011-07-14
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J.Med.Chem., 55, 2012
3T3U
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR, RM-1-130
Descriptor:Calmodulin-domain protein kinase 1, 3-(6-methoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, DIMETHYL SULFOXIDE, ...
Authors:Larson, E.T., Merritt, E.A.
Deposit date:2011-07-25
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J.Med.Chem., 55, 2012
3T3V
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR, RM-1-87
Descriptor:Calmodulin-domain protein kinase 1, 3-(6-methoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1,2-ETHANEDIOL
Authors:Larson, E.T., Merritt, E.A.
Deposit date:2011-07-25
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J.Med.Chem., 55, 2012
2C0N
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CRYSTAL STRUCTURE OF A197 FROM STIV
Descriptor:A197, 1,4-DIETHYLENE DIOXIDE, SULFATE ION, ...
Authors:Larson, E.T., Reiter, D., Young, M., Lawrence, C.M.
Deposit date:2005-09-06
Release date:2005-09-29
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of A197 from Sulfolobus Turreted Icosahedral Virus: A Crenarchaeal Viral Glycosyltransferase Exhibiting the Gt-A Fold.
J.Virol., 80, 2006
2CO5
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F93 FROM STIV, A WINGED-HELIX DNA-BINDING PROTEIN
Descriptor:VIRAL PROTEIN F93
Authors:Larson, E.T., Reiter, D., Lawrence, C.M.
Deposit date:2006-05-25
Release date:2006-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Winged-Helix Protein from Sulfolobus Turreted Icosahedral Virus Points Toward Stabilizing Disulfide Bonds in the Intracellular Proteins of a Hyperthermophilic Virus.
Virology, 368, 2007
2J85
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B116 OF SULFOLOBUS TURRETED ICOSAHEDRAL VIRUS (STIV)
Descriptor:STIV B116
Authors:Larson, E.T., Reiter, D., Young, M.J., Lawrence, C.M.
Deposit date:2006-10-19
Release date:2006-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:A New DNA Binding Protein Highly Conserved in Diverse Crenarchaeal Viruses
Virology, 363, 2007
2PGF
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CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE FROM PLASMODIUM VIVAX IN COMPLEX WITH ADENOSINE
Descriptor:adenosine deaminase, ZINC ION, ADENOSINE, ...
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-04-09
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2PGR
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CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE FROM PLASMODIUM VIVAX IN COMPLEX WITH PENTOSTATIN
Descriptor:adenosine deaminase, ZINC ION, 2'-DEOXYCOFORMYCIN, ...
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-04-10
Release date:2007-04-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2QVN
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CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE FROM PLASMODIUM VIVAX IN COMPLEX WITH GUANOSINE
Descriptor:Adenosine deaminase, GUANOSINE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-08-08
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
3BJE
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI NUCLEOSIDE PHOSPHORYLASE SHOWS URIDINE PHOSPHORYLASE ACTIVITY
Descriptor:Nucleoside phosphorylase, putative, RIBOSE-1-PHOSPHATE, ...
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-12-03
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase
J.Mol.Biol., 396, 2010
3CXM
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LEISHMANIA NAIFFI URACIL-DNA GLYCOSYLASE IN COMPLEX WITH 5-BROMOURACIL
Descriptor:Uracil-DNA glycosylase, BROMIDE ION, 5-bromopyrimidine-2,4(1H,3H)-dione, ...
Authors:Larson, E.T., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-04-24
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of Leishmania naiffi uracil-DNA glycosylase in complex with several ligands identified with fragment cocktail crystallography.
To be Published
3E8J
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COPROPORPHYRINOGEN III OXIDASE FROM LEISHMANIA NAIFFI
Descriptor:COPROPORPHYRINOGEN III OXIDASE, ACETATE ION, GLYCEROL
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-08-19
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural investigation of a protozoan coproporphyrinogen III oxidase
To be Published
3EJO
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COPROPORPHYRINOGEN III OXIDASE FROM LEISHMANIA DONOVANI
Descriptor:Coproporphyrinogen III oxidase, ACETATE ION
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-09-18
Release date:2008-10-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural investigation of a protozoan coproporphyrinogen iii oxidase
to be published
3F75
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ACTIVATED TOXOPLASMA GONDII CATHEPSIN L (TGCPL) IN COMPLEX WITH ITS PROPEPTIDE
Descriptor:Cathepsin L Protease, Cathepsin L Propeptide, CHLORIDE ION, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-11-07
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J.Biol.Chem., 284, 2009
3IAL
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GIARDIA LAMBLIA PROLYL-TRNA SYNTHETASE IN COMPLEX WITH PROLYL-ADENYLATE
Descriptor:Prolyl-tRNA synthetase, 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-07-14
Release date:2009-08-11
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr.,Sect.D, 68, 2012
3KFL
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LEISHMANIA MAJOR METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH METHIONYLADENYLATE AND PYROPHOSPHATE
Descriptor:Methionyl-tRNA synthetase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate, PYROPHOSPHATE 2-, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-10-27
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie, 93, 2011
3KKK
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Y92C CATALYTIC RESIDUE MUTANT OF PHOSPHOGLYCERATE MUTASE FROM PLASMODIUM FALCIPARUM
Descriptor:Phosphoglycerate mutase
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-11-05
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of a phosphoglycerate mutase from Plasmodium falciparum
To be Published
3LSQ
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE
Descriptor:Seryl-tRNA synthetase, MALONATE ION, SODIUM ION
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-12
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei.
to be published
3LSS
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE IN COMPLEX WITH ATP
Descriptor:Seryl-tRNA synthetase, ADENOSINE-5'-TRIPHOSPHATE, MALONATE ION, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-12
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei.
to be published
3LX3
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS) IN COMPLEX WITH XANTHOPTERIN
Descriptor:6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, 2-amino-1,5-dihydropteridine-4,6-dione
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-24
Release date:2010-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3LZE
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS), E37C CATALYTIC RESIDUE MUTANT
Descriptor:Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, PTERINE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-01
Release date:2010-04-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3M0N
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS), E37A CATALYTIC RESIDUE MUTANT
Descriptor:Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, PTERINE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-03
Release date:2010-04-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3M4P
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ENTAMOEBA HISTOLYTICA ASPARAGINYL-TRNA SYNTHETASE (ASNRS) IN COMPLEX WITH ASPARAGINYL-ADENYLATE
Descriptor:Asparaginyl-tRNA synthetase, putative, 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-11
Release date:2010-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica.
to be published
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