Author results

1A0N
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NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES
Descriptor:PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN
Authors:Renzoni, D.A., Pugh, D.J.R., Siligardi, G., Das, P., Morton, C.J., Rossi, C., Waterfield, M.D., Campbell, I.D., Ladbury, J.E.
Deposit date:1997-12-05
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
1AZG
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NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor:PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN
Authors:Renzoni, D.A., Pugh, D.J.R., Siligardi, G., Das, P., Morton, C.J., Rossi, C., Waterfield, M.D., Campbell, I.D., Ladbury, J.E.
Deposit date:1997-11-18
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
1B55
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PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Descriptor:TYROSINE-PROTEIN KINASE BTK, ZINC ION, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Djinovic Carugo, K., Baraldi, E., Hyvoenen, M., Lo Surdo, P., Riley, A.M., Potter, B.V.L., O'Brien, R., Ladbury, J.E., Saraste, M.
Deposit date:1999-01-12
Release date:1999-06-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Structure Fold.Des., 7, 1999
1G83
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CRYSTAL STRUCTURE OF FYN SH3-SH2
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN
Authors:Arold, S.T., Ulmer, T.S., Mulhern, T.D., Werner, J.M., Ladbury, J.E., Campbell, I.D., Noble, M.E.M.
Deposit date:2000-11-16
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
J.Biol.Chem., 276, 2001
1KLR
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NMR STRUCTURE OF THE ZFY-6T[Y10F] ZINC FINGER
Descriptor:ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION
Authors:Lachenmann, M.J., Ladbury, J.E., Phillips, N.B., Narayana, N., Qian, X., Weiss, M.A.
Deposit date:2001-12-12
Release date:2002-03-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
1KLS
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NMR STRUCTURE OF THE ZFY-6T[Y10L] ZINC FINGER
Descriptor:ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION
Authors:Lachenmann, M.J., Ladbury, J.E., Phillips, N.B., Narayana, N., Qian, X., Weiss, M.A.
Deposit date:2001-12-12
Release date:2002-03-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
1LR1
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SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE BACTERIAL CHROMATIN-STRUCTURING PROTEIN H-NS
Descriptor:dna-binding protein h-ns
Authors:Esposito, D., Petrovic, A., Harris, R., Ono, S., Eccleston, J., Mbabaali, A., Haq, I., Higgins, C.F., Hinton, J.C.D., Driscoll, P.C., Ladbury, J.E.
Deposit date:2002-05-14
Release date:2003-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:H-NS Oligomerization Domain Structure Reveals the Mechanism for High Order Self-association of the Intact Protein
J.Mol.Biol., 324, 2002
1XF7
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HIGH RESOLUTION NMR STRUCTURE OF THE WILMS' TUMOR SUPPRESSOR PROTEIN (WT1) FINGER 3
Descriptor:Wilms' Tumor Protein, ZINC ION
Authors:Lachenmann, M.J., Ladbury, J.E., Dong, J., Huang, K., Carey, P., Weiss, M.A.
Deposit date:2004-09-14
Release date:2004-12-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity
Biochemistry, 43, 2004
1XRZ
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NMR STRUCTURE OF A ZINC FINGER WITH CYCLOHEXANYLALANINE SUBSTITUTED FOR THE CENTRAL AROMATIC RESIDUE
Descriptor:Zinc finger Y-chromosomal protein, ZINC ION
Authors:Lachenmann, M.J., Ladbury, J.E., Qian, X., Huang, K., Singh, R., Weiss, M.A.
Deposit date:2004-10-17
Release date:2004-11-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice
Protein Sci., 13, 2004
2BUG
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SOLUTION STRUCTURE OF THE TPR DOMAIN FROM PROTEIN PHOSPHATASE 5 IN COMPLEX WITH HSP90 DERIVED PEPTIDE
Descriptor:SERINE/THREONINE PROTEIN PHOSPHATASE 5, HSP90
Authors:Cliff, M.J., Harris, R., Barford, D., Ladbury, J.E., Williams, M.A.
Deposit date:2005-06-13
Release date:2006-03-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational Diversity in the Tpr Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90.
Structure, 14, 2006
2JYQ
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NMR STRUCTURE OF THE APO V-SRC SH2 DOMAIN
Descriptor:Tyrosine-protein kinase transforming protein Src
Authors:Taylor, J.D., Ababou, A., Williams, M.A., Ladbury, J.E.
Deposit date:2007-12-17
Release date:2008-06-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design
Proteins, 73, 2008
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2O2O
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SOLUTION STRUCTURE OF DOMAIN B FROM HUMAN CIN85 PROTEIN
Descriptor:SH3-domain kinase-binding protein 1
Authors:Ababou, A., Pfuhl, M., Dikic, I., Ladbury, J.E.
Deposit date:2006-11-30
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigation of Domain B from Human Cin85 Protein: Structure, Dynamics and Proline-Rich Motif Binding
To be Published
3NR7
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CRYSTAL STRUCTURE OF S. TYPHIMURIUM H-NS 1-83
Descriptor:DNA-binding protein H-NS
Authors:Arold, S.T., Leonard, P.G., Parkinson, G.N., Ladbury, J.E.
Deposit date:2010-06-30
Release date:2010-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:H-NS forms a superhelical protein scaffold for DNA condensation.
Proc.Natl.Acad.Sci.USA, 107, 2010
4TT2
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH H4(1-20)K5AC PEPTIDE
Descriptor:ATPase family AAA domain-containing protein 2, Histone H4K5Ac
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TT4
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH H3(1-21)K14AC PEPTIDE
Descriptor:ATPase family AAA domain-containing protein 2, Histone H3(1-21)K4Ac, SULFATE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TT6
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN DOUBLE MUTANT N1063A-Y1064A IN APO FORM
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-19
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TTE
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH METHYL 3-AMINO-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)BENZOATE
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-20
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TU4
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CRYSTAL STRUCTURE OF ATAD2A BROMODOMAIN COMPLEXED WITH 3-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-5-[(PHENYLSULFONYL)AMINO]BENZOICACID
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, GLYCEROL, ...
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-23
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
4TU6
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CRYSTAL STRUCTURE OF APO ATAD2A BROMODOMAIN WITH N1064 ALTERNATE CONFORMATION
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION
Authors:Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.
Deposit date:2014-06-23
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466, 2015
1B05
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STRUCTURE OF OLIGO-PEPTIDE BINDING PROTEIN COMPLEXED WITH LYS-CYS-LYS
Descriptor:PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, PEPTIDE LYS-CYS-LYS, URANIUM ATOM
Authors:Tame, J.R.H., Wilkinson, A.J.
Deposit date:1998-11-20
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
1B32
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KMK
Descriptor:PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (LYS-MET-LYS), URANYL (VI) ION, ...
Authors:Tame, J.R.H., Wilkinson, A.J.
Deposit date:1998-12-15
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
1B3F
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KHK
Descriptor:PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (LYS-HIS-LYS), URANYL (VI) ION
Authors:Tame, J.R.H., Wilkinson, A.J.
Deposit date:1998-12-14
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
1B3G
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KIK
Descriptor:PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (LYS-ILE-LYS), URANYL (VI) ION
Authors:Tame, J.R.H., Wilkinson, A.J.
Deposit date:1998-12-14
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
1B3L
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OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KGK
Descriptor:PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN), PROTEIN (LYS-GLY-LYS), URANYL (VI) ION
Authors:Tame, J.R.H., Wilkinson, A.J.
Deposit date:1998-12-14
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic and calorimetric analysis of peptide binding to OppA protein.
J.Mol.Biol., 291, 1999
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