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1XSL
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP
Descriptor:5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSN
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP AND DDTTP
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSP
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH NICKED DNA AND PYROPHOSPHATE
Descriptor:5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1NZP
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SOLUTION STRUCTURE OF THE LYASE DOMAIN OF HUMAN DNA POLYMERASE LAMBDA
Descriptor:DNA polymerase lambda
Authors:DeRose, E.F., Kirby, T.W., Mueller, G.A., Bebenek, K., Garcia-Diaz, M., Blanco, L., Kunkel, T.A., London, R.E.
Deposit date:2003-02-19
Release date:2003-08-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda
Biochemistry, 42, 2003
1RUN
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CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Descriptor:DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*G )-3'), PROTEIN (CATABOLITE GENE ACTIVATOR PROTEIN (CAP)), ...
Authors:Parkinson, G.N., Gunasekera, A., Vojtechovsky, J., Zhang, X., Kunkel, T.A., Berman, H.M., Ebright, R.H.
Deposit date:1996-05-26
Release date:1997-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Aromatic hydrogen bond in sequence-specific protein DNA recognition.
Nat.Struct.Biol., 3, 1996
1RZT
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CRYSTAL STRUCTURE OF DNA POLYMERASE LAMBDA COMPLEXED WITH A TWO NUCLEOTIDE GAP DNA MOLECULE
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Pedersen, L.C., Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Blanco, L., Kunkel, T.A.
Deposit date:2003-12-29
Release date:2004-03-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.
Mol.Cell, 13, 2004
1T8E
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T7 DNA POLYMERASE TERNARY COMPLEX WITH DCTP AT THE INSERTION SITE.
Descriptor:5'-D(P*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DT))-3', 25-MER, DNA polymerase, ...
Authors:Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Deposit date:2004-05-12
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
1TK0
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T7 DNA POLYMERASE TERNARY COMPLEX WITH 8 OXO GUANOSINE AND DDCTP AT THE INSERTION SITE
Descriptor:5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*A*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG))-3', 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ...
Authors:Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Deposit date:2004-06-07
Release date:2004-08-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
1TK5
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T7 DNA POLYMERASE BINARY COMPLEX WITH 8 OXO GUANOSINE IN THE TEMPLATING STRAND
Descriptor:5'-D(*CP*GP*AP*AP*A*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG)P*TP*GP*CP*AP*A)-3', 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ...
Authors:Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Deposit date:2004-06-08
Release date:2004-08-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
1TK8
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T7 DNA POLYMERASE TERNARY COMPLEX WITH 8 OXO GUANOSINE AND DAMP AT THE ELONGATION SITE
Descriptor:5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DA))-3', 5'-D(*CP*CP*CP*AP*(8OG)P*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ...
Authors:Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Deposit date:2004-06-08
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
1TKD
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T7 DNA POLYMERASE TERNARY COMPLEX WITH 8 OXO GUANOSINE AND DCMP AT THE ELONGATION SITE
Descriptor:DNA (5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DOC))-3'), DNA (5'-D(*CP*CP*CP*AP*(8OG)P*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3'), DNA polymerase, ...
Authors:Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Deposit date:2004-06-08
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
1ZYQ
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T7 DNA POLYMERASE IN COMPLEX WITH 8OG AND INCOMING DDATP
Descriptor:5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG))-3', 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ...
Authors:Brieba, L.G., Kokoska, R.J., Bebenek, K., Kunkel, T.A., Ellenberger, T.
Deposit date:2005-06-10
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A lysine residue in the fingers subdomain of t7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.
Structure, 13, 2005
2BCQ
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DNA POLYMERASE LAMBDA IN COMPLEX WITH A DNA DUPLEX CONTAINING AN UNPAIRED DTMP
Descriptor:5'-D(P*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Cell(Cambridge,Mass.), 124, 2006
2BCR
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DNA POLYMERASE LAMBDA IN COMPLEX WITH A DNA DUPLEX CONTAINING AN UNPAIRED DAMP
Descriptor:5'-D(P*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*AP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Cell(Cambridge,Mass.), 124, 2006
2BCS
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DNA POLYMERASE LAMBDA IN COMPLEX WITH A DNA DUPLEX CONTAINING AN UNPAIRED DCMP
Descriptor:5'-D(*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*CP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Cell(Cambridge,Mass.), 124, 2006
2BCU
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DNA POLYMERASE LAMBDA IN COMPLEX WITH A DNA DUPLEX CONTAINING AN UNPAIRED DAMP AND A T:T MISMATCH
Descriptor:5'-D(P*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*TP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*AP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Cell(Cambridge,Mass.), 124, 2006
2BCV
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DNA POLYMERASE LAMBDA IN COMPLEX WITH DTTP AND A DNA DUPLEX CONTAINING AN UNPAIRED DTMP
Descriptor:5'-D(P*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*AP*(O2C))-3', 5'-D(*CP*GP*GP*CP*AP*GP*TP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Cell(Cambridge,Mass.), 124, 2006
2GWS
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA WITH A G/G MISMATCH IN THE PRIMER TERMINUS
Descriptor:5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Picher, A.J., Bebenek, K., Pedersen, L.C., Kunkel, T.A., Blanco, L.
Deposit date:2006-05-05
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Promiscuous mismatch extension by human DNA polymerase lambda.
Nucleic Acids Res., 34, 2006
2IHM
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POLYMERASE MU IN TERNARY COMPLEX WITH GAPPED 11MER DNA DUPLEX AND BOUND INCOMING NUCLEOTIDE
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Moon, A.F., Pedersen, L.C., Kunkel, T.A.
Deposit date:2006-09-26
Release date:2006-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into the substrate specificity of DNA Polymerase mu.
Nat.Struct.Mol.Biol., 14, 2007
2L7D
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RIBONUCLEOTIDE PERTURBATION OF DNA STRUCTURE: SOLUTION STRUCTURE OF [D(CGC)R(G)D(AATTCGCG)]2
Descriptor:5'-D(*CP*GP*C)-R(P*G)-D(P*AP*AP*TP*TP*CP*GP*CP*G)-3'
Authors:DeRose, E.F., Perera, L., Murray, M.S., Kunkel, T.A., London, R.E.
Deposit date:2010-12-07
Release date:2011-06-01
Last modified:2012-06-13
Method:SOLUTION NMR
Cite:Solution structure of the Dickerson DNA dodecamer containing a single ribonucleotide.
Biochemistry, 51, 2012
2PFN
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NA IN THE ACTIVE SITE OF DNA POLYMERASE LAMBDA
Descriptor:Template, Primer, Downstream Primer, ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2007-04-05
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFO
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DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND DUPNPP
Descriptor:Template, Primer, Downstream Primer, ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2007-04-05
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFP
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DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND DCTP
Descriptor:Template, Primer, Downstream Primer, ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2007-04-05
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFQ
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MANGANESE PROMOTES CATALYSIS IN A DNA POLYMERASE LAMBDA-DNA CRYSTAL
Descriptor:Template, Primer, Downstream Primer, ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Deposit date:2007-04-05
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
3C5F
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STRUCTURE OF A BINARY COMPLEX OF THE R517A POL LAMBDA MUTANT
Descriptor:DNA (5'-D(*DCP*DGP*DGP*DCP*DCP*DGP*DTP*DAP*DCP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DGP*DTP*DAP*DC)-3'), DNA (5'-D(P*DGP*DCP*DCP*DG)-3'), ...
Authors:Garcia-Diaz, M., Bebenek, K., Foley, M.C., Pedersen, L.C., Schlick, T., Kunkel, T.A.
Deposit date:2008-01-31
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.
Embo Rep., 9, 2008