1EK9
 
 | | 2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI | | Descriptor: | OUTER MEMBRANE PROTEIN TOLC | | Authors: | Koronakis, V, Sharff, A.J, Koronakis, E, Luisi, B, Hughes, C. | | Deposit date: | 2000-03-07 | | Release date: | 2000-06-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
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2V4D
 | | Re-refinement of MexA adaptor protein | | Descriptor: | MULTIDRUG RESISTANCE PROTEIN MEXA, SULFATE ION | | Authors: | Symmons, M.F, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | | Deposit date: | 2008-09-18 | | Release date: | 2009-04-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The Assembled Structure of a Complete Tripartite Bacterial Multidrug Efflux Pump.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4WHN
 | | Structure of toxin-activating acyltransferase (TAAT) | | Descriptor: | ApxC, CITRIC ACID | | Authors: | Crow, A, Greene, N.P, Hughes, C, Koronakis, V. | | Deposit date: | 2014-09-23 | | Release date: | 2015-06-03 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure of a bacterial toxin-activating acyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
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2WMZ
 | | Structure of a mutated TolC | | Descriptor: | CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, SODIUM ION, ... | | Authors: | Hinchliffe, P, Pei, X.Y, Symmons, M.F, Koronakis, E, Hughes, C, Koronakis, V. | | Deposit date: | 2009-07-03 | | Release date: | 2011-01-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of Sequential Open States in a Symmetrical Opening Transition of the Tolc Exit Duct.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2XMN
 | | High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices | | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Outer membrane protein TolC | | Authors: | Pei, X.Y, Koronakis, E, Hughes, C, Koronakis, V. | | Deposit date: | 2010-07-28 | | Release date: | 2011-01-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.
Proc. Natl. Acad. Sci. U.S.A., 108, 2011
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4TKO
 | | Structure of the periplasmic adaptor protein EmrA | | Descriptor: | EmrA, ISOPROPYL ALCOHOL, MAGNESIUM ION | | Authors: | Hinchliffe, P, Greene, N.P, Paterson, N.G, Crow, A, Hughes, C, Koronakis, V. | | Deposit date: | 2014-05-27 | | Release date: | 2014-07-09 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump.
Febs Lett., 588, 2014
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1T5E
 | | The structure of MexA | | Descriptor: | D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA | | Authors: | Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | | Deposit date: | 2004-05-04 | | Release date: | 2004-05-18 | | Last modified: | 2020-07-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the periplasmic component of a bacterial drug efflux pump
Proc.Natl.Acad.Sci.USA, 101, 2004
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7Z6W
 | | Complex of E. coli LolA and lipoprotein | | Descriptor: | Outer-membrane lipoprotein carrier protein, [(2~{S})-3-[(2~{S})-3-azanyl-2-(hexadecanoylamino)-3-oxidanylidene-propyl]sulfanyl-2-hexadecanoyloxy-propyl] hexadecanoate | | Authors: | Kaplan, E, Greene, N.P, Koronakis, V. | | Deposit date: | 2022-03-14 | | Release date: | 2022-09-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Z6X
 | | Complex of E. coli LolA R43L mutant and lipoprotein | | Descriptor: | Outer-membrane lipoprotein carrier protein, [(2~{S})-3-[(2~{S})-3-azanyl-2-(hexadecanoylamino)-3-oxidanylidene-propyl]sulfanyl-2-hexadecanoyloxy-propyl] hexadecanoate | | Authors: | Kaplan, E, Greene, N.P, Koronakis, V. | | Deposit date: | 2022-03-14 | | Release date: | 2022-09-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1TQQ
 | | Structure of TolC in complex with hexamminecobalt | | Descriptor: | COBALT HEXAMMINE(III), Outer membrane protein tolC | | Authors: | Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V. | | Deposit date: | 2004-06-18 | | Release date: | 2004-07-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
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4KKU
 | | Structure of BesA (Selenomethinone derivative - P212121) | | Descriptor: | Membrane fusion protein | | Authors: | Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V. | | Deposit date: | 2013-05-06 | | Release date: | 2013-07-10 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013
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4KKS
 | | Crystal Structure of BesA (C2 form) | | Descriptor: | Membrane fusion protein, PHOSPHATE ION | | Authors: | Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V. | | Deposit date: | 2013-05-06 | | Release date: | 2013-07-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013
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4KKT
 | | Crystal Structure of BesA (P21 form) | | Descriptor: | Membrane fusion protein | | Authors: | Greene, N.P, Hinchliffe, P, Crow, A, Ababou, A, Hughes, C, Koronakis, V. | | Deposit date: | 2013-05-06 | | Release date: | 2013-07-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.
Febs Lett., 587, 2013
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6FHM
 | | Crystal structure of the F47E mutant of the lipoprotein localization factor, LolA | | Descriptor: | GLYCEROL, Outer-membrane lipoprotein carrier protein | | Authors: | Kaplan, E, Greene, N.P, Crow, A, Koronakis, V. | | Deposit date: | 2018-01-15 | | Release date: | 2018-07-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4ZJQ
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4ZJL
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4ZLN
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4ZIV
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4ZIT
 | | Crystal structure of AcrB in P21 space group | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Multidrug efflux pump subunit AcrB, NICKEL (II) ION | | Authors: | Ababou, A, Koronakis, V. | | Deposit date: | 2015-04-28 | | Release date: | 2016-07-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.296 Å) | | Cite: | Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.
Plos One, 11, 2016
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4ZJO
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4ZIW
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4ZLL
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4ZLJ
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6YJJ
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6YJK
 | | Structure of CYRI-B (FAM49B) from Rhincodon typus | | Descriptor: | CYRI-B (FAM49B) | | Authors: | Kaplan, E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-10-14 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.
Acta Crystallogr D Struct Biol, 76, 2020
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