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1AXG
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CRYSTAL STRUCTURE OF THE VAL203->ALA MUTANT OF LIVER ALCOHOL DEHYDROGENASE COMPLEXED WITH COFACTOR NAD AND INHIBITOR TRIFLUOROETHANOL SOLVED TO 2.5 ANGSTROM RESOLUTION
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Bahnson, B.J., Goldstein, B.M., Klinman, J.P.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1A71
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TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL
Descriptor:LIVER ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1A72
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AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD
Descriptor:HORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1EKM
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CRYSTAL STRUCTURE AT 2.5 A RESOLUTION OF ZINC-SUBSTITUTED COPPER AMINE OXIDASE OF HANSENULA POLYMORPHA EXPRESSED IN ESCHERICHIA COLI
Descriptor:COPPER AMINE OXIDASE, ZINC ION
Authors:Chen, Z., Schwartz, B., Williams, N.K., Li, R., Klinman, J.P., Mathews, F.S.
Deposit date:2000-03-09
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Biochemistry, 39, 2000
3N9H
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CRYSTAL STRUCTURAL OF MUTANT Y305A IN THE COPPER AMINE OXIDASE FROM HANSENULA POLYMORPHA
Descriptor:Peroxisomal primary amine oxidase, COPPER (II) ION
Authors:Chen, Z., Datta, S., DuBois, J.L., Klinman, J.P., Mathews, F.S.
Deposit date:2010-05-30
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry, 49, 2010
3NBB
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CRYSTAL STRUCTURE OF MUTANT Y305F EXPRESSED IN E. COLI IN THE COPPER AMINE OXIDASE FROM HANSENULA POLYMORPHA
Descriptor:Peroxisomal primary amine oxidase, COPPER (II) ION
Authors:Chen, Z., Datta, S., DuBois, J.L., Klinman, J.P., Mathews, F.S.
Deposit date:2010-06-03
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry, 49, 2010
3NBJ
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CRYSTAL STRUCTURE OF Y305F MUTANT OF THE COPPER AMINE OXIDASE FROM HANSENULA POLYMORPHA EXPRESSED IN YEAST
Descriptor:Peroxisomal primary amine oxidase, COPPER (II) ION, PHOSPHATE ION
Authors:Chen, Z., Datta, S., DuBois, J.L., Klinman, J.P., Mathews, F.S.
Deposit date:2010-06-03
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry, 49, 2010
1OTV
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PQQC, PYRROLOQUINOLINQUINONE SYNTHASE C
Descriptor:Coenzyme PQQ synthesis protein C
Authors:Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Adachi, O., Klinman, J.P., SChwarzenbacher, R.
Deposit date:2003-03-23
Release date:2004-05-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Quinone Biogenesis: Structure and Mechanism of PqqC, the Final Catalyst in the Production of Pyrroloquinoline Quinone.
Proc.Natl.Acad.Sci.USA, 101, 2004
1OTW
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CRYSTAL STRUCTURE OF PQQC IN COMPLEX WITH PQQ AND A PUTATIVE H2O2
Descriptor:Coenzyme PQQ synthesis protein C, PYRROLOQUINOLINE QUINONE, HYDROGEN PEROXIDE
Authors:Magnusson, O.T., Toyama, H., Saeki, M., Rojas, A., Reed, J.C., Liddington, R.C., Klinman, J.P., Schwarzenbacher, R.
Deposit date:2003-03-23
Release date:2004-05-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZDR
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DHFR FROM BACILLUS STEAROTHERMOPHILUS
Descriptor:dihydrofolate reductase, SULFATE ION, GLYCEROL
Authors:Kim, H.S., Damo, S.M., Lee, S.Y., Wemmer, D., Klinman, J.P.
Deposit date:2005-04-14
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.
Biochemistry, 44, 2005
4WFO
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MANGANESE-SUBSTITUTED SOYBEAN LIPOXYGENASE-1
Descriptor:Seed linoleate 13S-lipoxygenase-1, MANGANESE (II) ION, 1,2-ETHANEDIOL, ...
Authors:Carr, C.A.M., Scouras, A.D., Klinman, J.P.
Deposit date:2014-09-16
Release date:2015-09-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Direct detection of active-site geometries in soybean lipoxygenase-1 by ENDOR
To Be Published
4WHA
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LIPOXYGENASE-1 (SOYBEAN) L546A/L754A MUTANT
Descriptor:Seed linoleate 13S-lipoxygenase-1, FE (III) ION, 1,2-ETHANEDIOL, ...
Authors:Scouras, A.D., Carr, C.A.M., Hu, S., Klinman, J.P.
Deposit date:2014-09-21
Release date:2014-11-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation.
J.Am.Chem.Soc., 136, 2014
3BNB
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LIPOXYGENASE-1 (SOYBEAN) I553L MUTANT
Descriptor:Seed lipoxygenase-1, FE (III) ION
Authors:Tomchick, D.R.
Deposit date:2007-12-14
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BNC
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LIPOXYGENASE-1 (SOYBEAN) I553G MUTANT
Descriptor:Seed lipoxygenase-1, FE (III) ION, ACETIC ACID
Authors:Tomchick, D.R.
Deposit date:2007-12-14
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BND
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LIPOXYGENASE-1 (SOYBEAN), I553V MUTANT
Descriptor:Seed lipoxygenase-1, FE (III) ION
Authors:Tomchick, D.R.
Deposit date:2007-12-14
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BNE
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LIPOXYGENASE-1 (SOYBEAN) I553A MUTANT
Descriptor:Seed lipoxygenase-1, FE (III) ION
Authors:Tomchick, D.R.
Deposit date:2007-12-14
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5SXY
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THE SOLUTION NMR STRUCTURE FOR THE PQQD TRUNCATION OF METHYLOBACTERIUM EXTORQUENS PQQCD REPRESENTING A FUNCTIONAL AND STAND-ALONE RIBOSOMALLY SYNTHESIZED AND POST-TRANSLATIONAL MODIFIED (RIPP) RECOGNITION ELEMENT (RRE)
Descriptor:Bifunctional coenzyme PQQ synthesis protein C/D
Authors:Evans, R.L., Xia, Y., Wilmot, C.M.
Deposit date:2016-08-10
Release date:2017-05-24
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone.
Biochemistry, 56, 2017
6OWM
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND PENTAFLUOROBENZYL ALCOHOL
Descriptor:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
Authors:Plapp, B.V.
Deposit date:2019-05-10
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published
6OWP
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND TRIFLUOROETHANOL
Descriptor:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
Authors:Plapp, B.V.
Deposit date:2019-05-10
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published
1AXE
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CRYSTAL STRUCTURE OF THE ACTIVE-SITE MUTANT PHE93->TRP OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH NAD AND INHIBITOR TRIFLUOROETHANOL
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Goldstein, B.M.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1A2V
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COPPER AMINE OXIDASE FROM HANSENULA POLYMORPHA
Descriptor:METHYLAMINE OXIDASE, COPPER (II) ION
Authors:Li, R., Mathews, F.S.
Deposit date:1998-01-12
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic study of yeast copper amine oxidase.
Acta Crystallogr.,Sect.D, 53, 1997
1F8N
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, NEW REFINEMENT
Descriptor:LIPOXYGENASE-1, FE (II) ION
Authors:Tomchick, D.R., Minor, W., Holman, T.
Deposit date:2000-06-30
Release date:2001-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGM
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, N694H MUTANT
Descriptor:SEED LIPOXYGENASE-1, FE (III) ION
Authors:Tomchick, D.R., Minor, W., Holman, T.R.
Deposit date:2000-07-28
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGO
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495A MUTANT
Descriptor:SEED LIPOXYGENASE-1, FE (III) ION
Authors:Tomchick, D.R., Minor, W., Holman, T.
Deposit date:2000-07-28
Release date:2001-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGQ
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495E MUTANT
Descriptor:SEED LIPOXYGENASE-1, FE (III) ION
Authors:Tomchick, D.R., Minor, W., Holman, T.
Deposit date:2000-07-28
Release date:2001-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
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