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4INR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU102
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INT
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU122
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU112
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4QLQ
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 8
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLS
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 11
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:De Bruin, G., Huber, E., Xin, B., Van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., Van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLT
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 2 (PR924)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLU
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 9
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
4QLV
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YCP IN COMPLEX WITH TRIPEPTIDIC EPOXYKETONE INHIBITOR 17
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:de Bruin, G., Huber, E., Xin, B., van Rooden, E., Al-Ayed, K., Kim, K., Kisselev, A., Driessen, C., van der Marel, G., Groll, M., Overkleeft, H.
Deposit date:2014-06-13
Release date:2014-07-23
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
J.Med.Chem., 57, 2014
5JHR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE PEPTIDIC EPOXYKETONE INHIBITOR 27
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2016-04-21
Release date:2016-08-03
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes.
J.Med.Chem., 59, 2016
5JHS
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YEAST 20S PROTEASOME IN COMPLEX WITH THE PEPTIDIC EPOXYKETONE INHIBITOR 15
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Huber, E.M., Groll, M.
Deposit date:2016-04-21
Release date:2016-08-03
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes.
J.Med.Chem., 59, 2016