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3RVC
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BU of 3rvc by Molmil
Effector domain of NS1 from influenza A/PR/8/34 containing a W187A mutation
Descriptor: Non-structural protein 1
Authors:Kerry, P.S, Long, E, Taylor, M.A, Russell, R.J.M.
Deposit date:2011-05-06
Release date:2011-08-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conservation of a crystallographic interface suggests a role for beta-sheet augmentation in influenza virus NS1 multifunctionality.
Acta Crystallogr.,Sect.F, 67, 2011
4KS1
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BU of 4ks1 by Molmil
Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-amino-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Descriptor: (3S,4R,5R)-4-(acetylamino)-3-amino-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Kerry, P.S, Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS2
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BU of 4ks2 by Molmil
Influenza Neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-carbamimidamido-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Descriptor: (3S,4R,5R)-4-(acetylamino)-3-carbamimidamido-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS4
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BU of 4ks4 by Molmil
Influenza Neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Descriptor: (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
3OA9
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BU of 3oa9 by Molmil
Effector domain of influenza A/Duck/Albany/76 NS1
Descriptor: Non-structural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-05
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9S
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BU of 3o9s by Molmil
Effector domain of influenza A/PR/8/34 NS1
Descriptor: Nonstructural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9R
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BU of 3o9r by Molmil
Effector domain of NS1 from influenza A/PR/8/34 containing a W187A mutation
Descriptor: Nonstructural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9Q
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BU of 3o9q by Molmil
Effector domain of NS1 from A/PR/8/34 containing a W187A mutation
Descriptor: Nonstructural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9T
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BU of 3o9t by Molmil
Effector domain from influenza A/PR/8/34 NS1
Descriptor: HEXAETHYLENE GLYCOL, Nonstructural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9U
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BU of 3o9u by Molmil
Effector domain of influenza A/PR/8/34 NS1
Descriptor: Nonstructural protein 1
Authors:Kerry, P.S, Lewis, A, Hale, B.G, Hass, C, Taylor, M.A, Randall, R.E, Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
4KS3
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BU of 4ks3 by Molmil
Influenza Neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Descriptor: (3S,4R,5R)-4-(acetylamino)-3-[4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS5
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BU of 4ks5 by Molmil
Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Descriptor: (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
8QJR
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BU of 8qjr by Molmil
BRG1 bromodomain in complex with VBC via compound 17
Descriptor: (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, CHLORIDE ION, Elongin-B, ...
Authors:Kerry, P.S, Hole, A.J, Perez-Dorado, J.I.
Deposit date:2023-09-13
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J.Med.Chem., 67, 2024
8QJS
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BU of 8qjs by Molmil
VHL/Elongin B/Elongin C complex with compound 155
Descriptor: (2S,4R)-1-[(2R)-2-[3-[2-(2-methoxyethoxy)ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Kerry, P.S, Hole, A.J, Perez-Dorado, J.I.
Deposit date:2023-09-13
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.191 Å)
Cite:PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J.Med.Chem., 67, 2024
8QJT
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BU of 8qjt by Molmil
BRM (SMARCA2) Bromodomain in complex with ligand 10
Descriptor: 2-[6-azanyl-5-[(1R,5S)-8-[2-(2-methoxyethoxy)pyridin-4-yl]-3,8-diazabicyclo[3.2.1]octan-3-yl]pyridazin-3-yl]phenol, CHLORIDE ION, Probable global transcription activator SNF2L2, ...
Authors:Kerry, P.S, Hole, A.J, Perez-Dorado, J.I.
Deposit date:2023-09-13
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.568 Å)
Cite:PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J.Med.Chem., 67, 2024
4D8S
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BU of 4d8s by Molmil
Influenza NA in complex with antiviral compound
Descriptor: CALCIUM ION, Neuraminidase, pentan-3-yl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid
Authors:Kerry, P.S, Russell, R.J.M.R.
Deposit date:2012-01-11
Release date:2013-02-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Exploring the interactions of unsaturated glucuronides with influenza virus sialidase.
J.Med.Chem., 55, 2012
7NAL
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BU of 7nal by Molmil
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1
Authors:Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAK
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BU of 7nak by Molmil
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)
Descriptor: NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
5BXZ
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BU of 5bxz by Molmil
H17 Bat Influenza NS1 RNA Binding Domain
Descriptor: Non-structural protein 1
Authors:Kerry, P.S, Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
5BY1
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BU of 5by1 by Molmil
H18 Bat Influenza NS1 RNA Binding Domain
Descriptor: DI(HYDROXYETHYL)ETHER, Non-structural protein 1, PENTAETHYLENE GLYCOL
Authors:Kerry, P.S, Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
4GB1
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BU of 4gb1 by Molmil
Synthesis and Evaluation of Novel 3-C-alkylated-Neu5Ac2en Derivatives as Probes of Influenza Virus Sialidase 150-loop flexibility
Descriptor: 5-acetamido-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-phenylprop-2-en-1-yl]-D-glycero-L-altro-non-2-enonic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Rudrawar, S, Rameix-Welti, M.-A, Maggioni, A, Dyason, J.C, Rose, F.J, van der Werf, S, Thomson, R.J, Naffakh, N, Russell, R.J.M, von Itzstein, M.
Deposit date:2012-07-26
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Org.Biomol.Chem., 10, 2012
4M3M
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BU of 4m3m by Molmil
Influenza Neuraminidase in complex with a stereomutated analogue of Oseltamivir carboxylate
Descriptor: (3R,4S,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Kerry, P.S.
Deposit date:2013-08-06
Release date:2014-02-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate.
Org.Biomol.Chem., 12, 2014
4MJV
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BU of 4mjv by Molmil
Influenza Neuraminidase in complex with a novel antiviral compound
Descriptor: (2E,5S,9R,10S)-10-(acetylamino)-2-imino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]dec-6-ene-7-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S.
Deposit date:2013-09-04
Release date:2014-01-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MJU
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BU of 4mju by Molmil
Influenza Neuraminidase in complex with a novel antiviral compound
Descriptor: (5R,9R,10S)-10-(acetylamino)-2-amino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]deca-2,6-diene-7-carboxylic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S.
Deposit date:2013-09-04
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor.
Angew.Chem.Int.Ed.Engl., 53, 2014
3L4Q
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BU of 3l4q by Molmil
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Descriptor: GLYCEROL, Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Hale, B.G, Kerry, P.S, Jackson, D, Precious, B.L, Gray, A, Killip, M.J, Randall, R.E, Russell, R.J.
Deposit date:2009-12-21
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Proc.Natl.Acad.Sci.USA, 107, 2010

 

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