Author results

3O9Q
  • Download 3o9q
  • View 3o9q
Molmil generated image of 3o9q
EFFECTOR DOMAIN OF NS1 FROM A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9R
  • Download 3o9r
  • View 3o9r
Molmil generated image of 3o9r
EFFECTOR DOMAIN OF NS1 FROM INFLUENZA A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9S
  • Download 3o9s
  • View 3o9s
Molmil generated image of 3o9s
EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9T
  • Download 3o9t
  • View 3o9t
Molmil generated image of 3o9t
EFFECTOR DOMAIN FROM INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1, HEXAETHYLENE GLYCOL
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9U
  • Download 3o9u
  • View 3o9u
Molmil generated image of 3o9u
EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3OA9
  • Download 3oa9
  • View 3oa9
Molmil generated image of 3oa9
EFFECTOR DOMAIN OF INFLUENZA A/DUCK/ALBANY/76 NS1
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-05
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3RVC
  • Download 3rvc
  • View 3rvc
Molmil generated image of 3rvc
EFFECTOR DOMAIN OF NS1 FROM INFLUENZA A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Long, E., Taylor, M.A., Russell, R.J.M.
Deposit date:2011-05-06
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conservation of a crystallographic interface suggests a role for beta-sheet augmentation in influenza virus NS1 multifunctionality.
Acta Crystallogr.,Sect.F, 67, 2011
4KS1
  • Download 4ks1
  • View 4ks1
Molmil generated image of 4ks1
INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-AMINO-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-amino-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, ...
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS2
  • Download 4ks2
  • View 4ks2
Molmil generated image of 4ks2
INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-CARBAMIMIDAMIDO-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-carbamimidamido-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS3
  • Download 4ks3
  • View 4ks3
Molmil generated image of 4ks3
INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-[4-(3-HYDROXYPROPYL)-1H-1,2,3-TRIAZOL-1-YL]-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-[4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS4
  • Download 4ks4
  • View 4ks4
Molmil generated image of 4ks4
INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-{4-[(1R)-1-HYDROXYPROPYL]-1H-1,2,3-TRIAZOL-1-YL}-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS5
  • Download 4ks5
  • View 4ks5
Molmil generated image of 4ks5
INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-[4-(2-HYDROXYPROPAN-2-YL)-1H-1,2,3-TRIAZOL-1-YL]-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4D8S
  • Download 4d8s
  • View 4d8s
Molmil generated image of 4d8s
INFLUENZA NA IN COMPLEX WITH ANTIVIRAL COMPOUND
Descriptor:Neuraminidase, CALCIUM ION, pentan-3-yl 2-(acetylamino)-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid
Authors:Kerry, P.S., Russell, R.J.M.R.
Deposit date:2012-01-11
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Exploring the interactions of unsaturated glucuronides with influenza virus sialidase.
J.Med.Chem., 55, 2012
4GB1
  • Download 4gb1
  • View 4gb1
Molmil generated image of 4gb1
SYNTHESIS AND EVALUATION OF NOVEL 3-C-ALKYLATED-NEU5AC2EN DERIVATIVES AS PROBES OF INFLUENZA VIRUS SIALIDASE 150-LOOP FLEXIBILITY
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-phenylprop-2-en-1-yl]-D-glycero-L-altro-non-2-enonic acid, CALCIUM ION
Authors:Kerry, P.S., Rudrawar, S., Rameix-Welti, M.-A., Maggioni, A., Dyason, J.C., Rose, F.J., van der Werf, S., Thomson, R.J., Naffakh, N., Russell, R.J.M., von Itzstein, M.
Deposit date:2012-07-26
Release date:2012-09-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Org.Biomol.Chem., 10, 2012
4M3M
  • Download 4m3m
  • View 4m3m
Molmil generated image of 4m3m
INFLUENZA NEURAMINIDASE IN COMPLEX WITH A STEREOMUTATED ANALOGUE OF OSELTAMIVIR CARBOXYLATE
Descriptor:Neuraminidase, (3R,4S,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, ...
Authors:Kerry, P.S.
Deposit date:2013-08-06
Release date:2014-02-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate.
Org.Biomol.Chem., 12, 2014
4MJU
  • Download 4mju
  • View 4mju
Molmil generated image of 4mju
INFLUENZA NEURAMINIDASE IN COMPLEX WITH A NOVEL ANTIVIRAL COMPOUND
Descriptor:Neuraminidase, (5R,9R,10S)-10-(acetylamino)-2-amino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]deca-2,6-diene-7-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S.
Deposit date:2013-09-04
Release date:2014-01-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor.
Angew.Chem.Int.Ed.Engl., 53, 2014
4MJV
  • Download 4mjv
  • View 4mjv
Molmil generated image of 4mjv
INFLUENZA NEURAMINIDASE IN COMPLEX WITH A NOVEL ANTIVIRAL COMPOUND
Descriptor:Neuraminidase, (2E,5S,9R,10S)-10-(acetylamino)-2-imino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]dec-6-ene-7-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S.
Deposit date:2013-09-04
Release date:2014-01-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor.
Angew.Chem.Int.Ed.Engl., 53, 2014
5BXZ
  • Download 5bxz
  • View 5bxz
Molmil generated image of 5bxz
H17 BAT INFLUENZA NS1 RNA BINDING DOMAIN
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
5BY1
  • Download 5by1
  • View 5by1
Molmil generated image of 5by1
H18 BAT INFLUENZA NS1 RNA BINDING DOMAIN
Descriptor:Non-structural protein 1, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL
Authors:Kerry, P.S., Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
3EYJ
  • Download 3eyj
  • View 3eyj
Molmil generated image of 3eyj
STRUCTURE OF INFLUENZA HAEMAGGLUTININ IN COMPLEX WITH AN INHIBITOR OF MEMBRANE FUSION
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain
Authors:Russell, R.J., Kerry, P.S., Stevens, D.J., Steinahuer, D.A., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2008-10-21
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
Proc.Natl.Acad.Sci.USA, 105, 2008
3EYK
  • Download 3eyk
  • View 3eyk
Molmil generated image of 3eyk
STRUCTURE OF INFLUENZA HAEMAGGLUTININ IN COMPLEX WITH AN INHIBITOR OF MEMBRANE FUSION
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 2-tert-butylbenzene-1,4-diol
Authors:Russell, R.J., Kerry, P.S., Stevens, D.J., Steinhauer, D.A., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2008-10-21
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
Proc.Natl.Acad.Sci.USA, 105, 2008
3EYM
  • Download 3eym
  • View 3eym
Molmil generated image of 3eym
STRUCTURE OF INFLUENZA HAEMAGGLUTININ IN COMPLEX WITH AN INHIBITOR OF MEMBRANE FUSION
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 2-tert-butylbenzene-1,4-diol
Authors:Russell, R.J., Kerry, P.S., Stevens, D.A., Steinhauer, D.A., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2008-10-21
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
Proc.Natl.Acad.Sci.USA, 105, 2008
3L4Q
  • Download 3l4q
  • View 3l4q
Molmil generated image of 3l4q
STRUCTURAL INSIGHTS INTO PHOSPHOINOSITIDE 3-KINASE ACTIVATION BY THE INFLUENZA A VIRUS NS1 PROTEIN
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta, GLYCEROL
Authors:Hale, B.G., Kerry, P.S., Jackson, D., Precious, B.L., Gray, A., Killip, M.J., Randall, R.E., Russell, R.J.
Deposit date:2009-12-21
Release date:2010-02-02
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Proc.Natl.Acad.Sci.USA, 107, 2010
3O9J
  • Download 3o9j
  • View 3o9j
Molmil generated image of 3o9j
INFLUENZA NA IN COMPLEX WITH COMPOUND 5
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-prop-2-en-1-yl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ...
Authors:Russell, R.J., Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.0002 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
3O9K
  • Download 3o9k
  • View 3o9k
Molmil generated image of 3o9k
INFLUENZA NA IN COMPLEX WITH COMPOUND 6
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-(4-methylphenyl)prop-2-en-1-yl]-D-glycero-D-galacto-non-2-enonic acid
Authors:Russell, R.J., Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4945 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010