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3PTE
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THE REFINED CRYSTALLOGRAPHIC STRUCTURE OF A DD-PEPTIDASE PENICILLIN-TARGET ENZYME AT 1.6 A RESOLUTION
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRANSPEPTIDASE
Authors:Kelly, J.A., Kuzin, A.P.
Deposit date:1994-08-05
Release date:1995-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution.
J.Mol.Biol., 254, 1995
9LYZ
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X-RAY CRYSTALLOGRAPHY OF THE BINDING OF THE BACTERIAL CELL WALL TRISACCHARIDE NAM-NAG-NAM TO LYSOZYME
Descriptor:HEN EGG WHITE LYSOZYME, BETA-N-ACETYLMURAMIC ACID, N-ACETYL-D-GLUCOSAMINE
Authors:Kelly, J.A., James, M.N.G.
Deposit date:1979-12-06
Release date:1980-02-27
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystallography of the binding of the bacterial cell wall trisaccharide NAM-NAG-NAM to lysozyme.
Nature, 282, 1979
1IKG
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MICHAELIS COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANYL-D-ALANINE
Authors:Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A.
Deposit date:2001-05-03
Release date:2002-09-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
1IKI
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COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH THE PRODUCTS OF A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANINE, D-ALANINE
Authors:Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A.
Deposit date:2001-05-03
Release date:2002-09-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
1PW1
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NON-COVALENT COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH A HIGHLY SPECIFIC PENICILLIN
Descriptor:D-alanyl-D-alanine carboxypeptidase, (2S,5R,6R)-6-{[(6R)-6-(GLYCYLAMINO)-7-OXIDO-7-OXOHEPTANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE, GLYCEROL, ...
Authors:Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Deposit date:2003-06-30
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
1PW8
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COVALENT ACYL ENZYME COMPLEX OF THE R61 DD-PEPTIDASE WITH A HIGHLY SPECIFIC CEPHALOSPORIN
Descriptor:D-alanyl-D-alanine carboxypeptidase, (6R,7R)-3-[(ACETYLOXY)METHYL]-7-{[(6S)-6-(GLYCYLAMINO)-7-OXIDO-7-OXOHEPTANOYL]AMINO}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCTANE-2-CARBOXYLATE, GLYCEROL
Authors:Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
1PWC
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PENICILLOYL ACYL ENZYME COMPLEX OF THE STREPTOMYCES R61 DD-PEPTIDASE WITH PENICILLIN G
Descriptor:D-alanyl-D-alanine carboxypeptidase, OPEN FORM - PENICILLIN G
Authors:Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
1PWD
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COVALENT ACYL ENZYME COMPLEX OF THE STREPTOMYCES R61 DD-PEPTIDASE WITH CEPHALOSPORIN C
Descriptor:D-alanyl-D-alanine carboxypeptidase precursor, (2R)-5-(acetyloxymethyl)-2-[(1R)-1-[[(5R)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexanoyl]amino]-2-oxidanylidene-ethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
Authors:Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
1PWG
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COVALENT PENICILLOYL ACYL ENZYME COMPLEX OF THE STREPTOMYCES R61 DD-PEPTIDASE WITH A HIGHLY SPECIFIC PENICILLIN
Descriptor:D-alanyl-D-alanine carboxypeptidase, (2R,4S)-2-[(1R)-1-{[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
Authors:Silvaggi, N.R., Josephine, H.R., Pratt, R.F., Kelly, J.A.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.074 Å)
Cite:Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin"
J.Mol.Biol., 345, 2005
1SCW
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TOWARD BETTER ANTIBIOTICS: CRYSTAL STRUCTURE OF R61 DD-PEPTIDASE INHIBITED BY A NOVEL MONOCYCLIC PHOSPHATE INHIBITOR
Descriptor:D-alanyl-D-alanine carboxypeptidase, (2Z)-3-{[OXIDO(OXO)PHOSPHINO]OXY}-2-PHENYLACRYLATE, GLYCEROL
Authors:Silvaggi, N.R., Kaur, K., Adediran, S.A., Pratt, R.F., Kelly, J.A.
Deposit date:2004-02-12
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Toward Better Antibiotics: Crystallographic Studies of a Novel Class of DD-Peptidase/beta-Lactamase Inhibitors.
Biochemistry, 43, 2004
1SDE
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TOWARD BETTER ANTIBIOTICS: CRYSTAL STRUCTURE OF D-ALA-D-ALA PEPTIDASE INHIBITED BY A NOVEL BICYCLIC PHOSPHATE INHIBITOR
Descriptor:D-alanyl-D-alanine carboxypeptidase, 2-[(DIOXIDOPHOSPHINO)OXY]BENZOATE, GLYCEROL
Authors:Silvaggi, N.R., Kaur, K., Adediran, S.A., Pratt, R.F., Kelly, J.A.
Deposit date:2004-02-13
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Toward better antibiotics: crystallographic studies of a novel class of DD-peptidase/beta-lactamase inhibitors
Biochemistry, 43, 2004
1HVB
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CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, 5-{3-(S)-(4-(R)-ACETYLAMINO-4-CARBOXY-BUTYRYLAMINO)-3-[1-(R)-(1-(R)-CARBOXY-ETHYLCARBAMOYL)-ETHYLCARBAMOYL]-PROPYL}-2-(CARBOXY-PHENYLACETYLAMINO-METHYL)-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
Authors:McDonough, M.A., Lee, W., Silvaggi, N.R., Mobashery, S., Kelly, J.A.
Deposit date:2001-01-08
Release date:2001-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proc.Natl.Acad.Sci.USA, 98, 2001
1MPL
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CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE
Descriptor:D-alanyl-D-alanine carboxypeptidase, GLYCYL-L-A-AMINOPIMELYL-E-(D-2-AMINOETHYL)PHOSPHONATE, GLYCEROL
Authors:Silvaggi, N.R., Anderson, J.W., Brinsmade, S.R., Pratt, R.F., Kelly, J.A.
Deposit date:2002-09-12
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The Crystal Structure of Phosphonate-Inhibited d-Ala-d-Ala Peptidase Reveals an Analogue of a Tetrahedral Transition State.
Biochemistry, 42, 2003
1CP9
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CRYSTAL STRUCTURE OF PENICILLIN G ACYLASE FROM THE BRO1 MUTANT STRAIN OF PROVIDENCIA RETTGERI
Descriptor:Penicillin G amidase, SULFATE ION, CALCIUM ION
Authors:McDonough, M.A., Klei, H.E., Kelly, J.A.
Deposit date:1999-06-12
Release date:1999-06-24
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of penicillin G acylase from the Bro1 mutant strain of Providencia rettgeri.
Protein Sci., 8, 1999
1YQS
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INHIBITION OF THE R61 DD-PEPTIDASE BY N-BENZOYL-BETA-SULTAM
Descriptor:D-alanyl-D-alanine carboxypeptidase, 2-(BENZOYLAMINO)ETHANESULFONIC ACID, GLYCEROL
Authors:Ahmed, N., Cordaro, M., Laws, A.P., Delmarcelle, M., Silvaggi, N.R., Kelly, J.A., Page, M.I.
Deposit date:2005-02-02
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inactivation of Bacterial dd-Peptidase by beta-Sultams.
Biochemistry, 44, 2005
1CEF
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CEFOTAXIME COMPLEXED WITH THE STREPTOMYCES R61 DD-PEPTIDASE
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRANSPEPTIDASE, CEFOTAXIME, C3' cleaved, ...
Authors:Knox, J.R., Kuzin, A.P.
Deposit date:1995-01-12
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases.
Biochemistry, 34, 1995
1CEG
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CEPHALOTHIN COMPLEXED WITH DD-PEPTIDASE
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRANSPEPTIDASE, CEPHALOTHIN GROUP
Authors:Knox, J.R., Kuzin, A.P.
Deposit date:1995-01-12
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases.
Biochemistry, 34, 1995
2BLM
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BETA-LACTAMASE OF BACILLUS LICHENIFORMIS 749(SLASH)C AT 2 ANGSTROMS RESOLUTION
Descriptor:BETA-LACTAMASE
Authors:Moews, P.C., Knox, J.R., Dideberg, O.
Deposit date:1990-02-02
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution.
Proteins, 7, 1990
1TON
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RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION
Descriptor:TONIN, ZINC ION
Authors:Fujinaga, M., James, M.N.G.
Deposit date:1987-06-03
Release date:1988-01-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
J.Mol.Biol., 195, 1987