Author results

1SSX
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0.83A RESOLUTION CRYSTAL STRUCTURE OF ALPHA-LYTIC PROTEASE AT PH 8
Descriptor:Alpha-lytic protease, SULFATE ION, GLYCEROL
Authors:Fuhrmann, C.N., Agard, D.A.
Deposit date:2004-03-24
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.83 Å)
Cite:The 0.83A Resolution Crystal Structure of alpha-Lytic Protease Reveals the Detailed Structure of the Active Site and Identifies a Source of Conformational Strain.
J.Mol.Biol., 338, 2004
2H5D
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0.9A RESOLUTION CRYSTAL STRUCTURE OF ALPHA-LYTIC PROTEASE COMPLEXED WITH A TRANSITION STATE ANALOGUE, MEOSUC-ALA-ALA-PRO-VAL BORONIC ACID
Descriptor:ALPHA-LYTIC PROTEASE, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, SULFATE ION, ...
Authors:Fuhrmann, C.N., Agard, D.A.
Deposit date:2006-05-25
Release date:2006-09-26
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
3M7U
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CRYSTAL STRUCTURE OF ALPHA-LYTIC PROTEASE SB1+2 R64A/E182Q MUTANT
Descriptor:Alpha-lytic protease, SELF-PROTEOLYSIS PRODUCT (RESIDUES 184-187), SULFATE ION
Authors:Agard, D.A., Erciyas Bailey, F.P., Waddling, C.A.
Deposit date:2010-03-17
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Quantifying protein unfolding cooperativity with acid sensitive probes: Interdomain salt bridge contributions to unfolding cooperativity are combined efficiently in alpha-Lytic Protease
To be Published
3URD
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T181A MUTANT OF ALPHA-LYTIC PROTEASE
Descriptor:Alpha-lytic protease, SULFATE ION, GLYCEROL
Authors:Kelch, B.A., Agard, D.A.
Deposit date:2011-11-22
Release date:2012-05-23
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
3URC
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T181G MUTANT OF ALPHA-LYTIC PROTEASE
Descriptor:Alpha-lytic protease, SULFATE ION, GLYCEROL
Authors:Kelch, B.A., Agard, D.A.
Deposit date:2011-11-22
Release date:2012-05-23
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
2PFE
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CRYSTAL STRUCTURE OF THERMOBIFIDA FUSCA PROTEASE A (TFPA)
Descriptor:Alkaline serine protease, SULFATE ION, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ...
Authors:Kelch, B.A., Agard, D.A.
Deposit date:2007-04-04
Release date:2007-07-03
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (1.436 Å)
Cite:Mesophile versus Thermophile: Insights Into the Structural Mechanisms of Kinetic Stability
J.Mol.Biol., 370, 2007
3URE
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REPACK MUTANT (T181I, W199L, Q210I) OF ALPHA-LYTIC PROTEASE
Descriptor:Alpha-lytic protease, SULFATE ION
Authors:Kelch, B.A., Agard, D.A.
Deposit date:2011-11-22
Release date:2012-05-23
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
3M7T
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CRYSTAL STRUCTURE OF ALPHA-LYTIC PROTEASE SB2+3 E8A/R105S MUTANT
Descriptor:Alpha-lytic protease, GLYCEROL, SULFATE ION
Authors:Agard, D.A., Erciyas Bailey, F.P., Waddling, C.A.
Deposit date:2010-03-17
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Quantifying protein unfolding cooperativity with acid sensitive probes: Interdomain salt bridge contributions to unfolding cooperativity are combined efficiently in alpha-Lytic Protease
To be Published
6BL5
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HEAD DECORATION PROTEIN FROM THE HYPERTHERMOPHILIC PHAGE P74-26
Descriptor:Head decoration protein
Authors:Stone, N.P., Hilbert, B.J., Hidalgo, D., Halloran, K.T., Kelch, B.A.
Deposit date:2017-11-09
Release date:2018-02-21
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.
Structure, 26, 2018
2OUA
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CRYSTAL STRUCTURE OF NOCARDIOPSIS PROTEASE (NAPASE)
Descriptor:Serine protease, SULFATE ION, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ...
Authors:Kelch, B.A., Agard, D.A.
Deposit date:2007-02-09
Release date:2007-02-20
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and mechanistic exploration of Acid resistance: kinetic stability facilitates evolution of extremophilic behavior
J.Mol.Biol., 368, 2007
5E0U
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HUMAN PCNA VARIANT (S228I) COMPLEXED WITH P21 AT 1.9 ANGSTROMS
Descriptor:Proliferating cell nuclear antigen, Cyclin-dependent kinase inhibitor 1
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
4ZNK
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN FROM (P 32 2 1 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNL
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN BOUND TO ADP BERYLLIUM FLUORIDE
Descriptor:Phage terminase large subunit, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.068 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
5E0V
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HUMAN PCNA VARIANT (S228I) COMPLEXED WITH FEN1 AT 2.1 ANGSTROMS
Descriptor:Proliferating cell nuclear antigen, Flap endonuclease 1
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
4ZNI
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN (I 2 3 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Sankaran, B., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
5KEG
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CRYSTAL STRUCTURE OF APOBEC3A IN COMPLEX WITH A SINGLE-STRANDED DNA
Descriptor:DNA dC->dU-editing enzyme APOBEC-3A, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ZINC ION, ...
Authors:Kouno, T., Hilbert, B.J., Silvas, T., Royer, W.E., Matsuo, H., Schiffer, C.A.
Deposit date:2016-06-09
Release date:2017-05-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Nat Commun, 8, 2017
4ZNJ
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN MUTANT R139A (I 2 3 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
5TGE
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THERMUS PHAGE P74-26 LARGE TERMINASE NUCLEASE DOMAIN
Descriptor:Phage terminase large subunit
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Kelch, B.A.
Deposit date:2016-09-27
Release date:2017-01-25
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.
Nucleic Acids Res., 45, 2017
5E0T
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HUMAN PCNA MUTANT - S228I
Descriptor:Proliferating cell nuclear antigen
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6653 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
4XXO
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CRYSTAL STRUCTURE OF HUMAN APOBEC3A
Descriptor:DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION, CHLORIDE ION
Authors:Bohn, M.F., Shandilya, S.M.D., Schiffer, C.A.
Deposit date:2015-01-30
Release date:2015-04-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.843 Å)
Cite:The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Structure, 23, 2015
3U61
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STRUCTURE OF T4 BACTERIOPHAGE CLAMP LOADER BOUND TO CLOSED CLAMP, DNA AND ATP ANALOG AND ADP
Descriptor:DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, DNA polymerase processivity component, ...
Authors:Kelch, B.A., Makino, D.L., O'Donnell, M., Kuriyan, J.
Deposit date:2011-10-11
Release date:2012-01-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
3GLG
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CRYSTAL STRUCTURE OF A MUTANT (GAMMAT157A) E. COLI CLAMP LOADER BOUND TO PRIMER-TEMPLATE DNA
Descriptor:DNA polymerase III subunit delta, DNA polymerase III subunit tau, DNA polymerase III subunit delta', ...
Authors:Simonetta, K.R., Seyedin, S.N., Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3U60
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STRUCTURE OF T4 BACTERIOPHAGE CLAMP LOADER BOUND TO OPEN CLAMP, DNA AND ATP ANALOG
Descriptor:DNA polymerase accessory protein 44, Template DNA strand, Primer DNA strand, ...
Authors:Kelch, B.A., Makino, D.L., O'Donnell, M., Kuriyan, J.
Deposit date:2011-10-11
Release date:2012-01-04
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
3GLF
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CRYSTAL STRUCTURE OF THE ECOLI CLAMP LOADER BOUND TO PRIMER-TEMPLATE DNA
Descriptor:DNA polymerase III subunit delta, DNA polymerase III subunit tau, DNA polymerase III subunit delta', ...
Authors:Simonetta, K.R., Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (3.388 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
3GLI
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CRYSTAL STRUCTURE OF THE E. COLI CLAMP LOADER BOUND TO PRIMER-TEMPLATE DNA AND PSI PEPTIDE
Descriptor:DNA polymerase III subunit delta, DNA polymerase III subunit tau, DNA polymerase III subunit delta', ...
Authors:Simonetta, K.R., Cantor, A.J., Kuriyan, J.
Deposit date:2009-03-12
Release date:2009-05-26
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
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