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1FMU
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STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP.
Descriptor:SACCHAROPEPSIN, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1FMX
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STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21
Descriptor:SACCHAROPEPSIN, BETA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1G0V
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV
Descriptor:PROTEINASE A, PROTEASE A INHIBITOR 3, BETA-D-MANNOSE, ...
Authors:Phylip, L.H., Lees, W., Brownsey, B.G., Bur, D., Dunn, B.M., Winther, J., Gustchina, A., Li, M., Copeland, T., Wlodawer, A., Kay, J.
Deposit date:2000-10-09
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
J.Biol.Chem., 276, 2001
1DP5
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-23
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
1DPJ
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3 PEPTIDE, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-27
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
1KA6
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SAP/SH2D1A BOUND TO PEPTIDE N-PY
Descriptor:SH2 DOMAIN PROTEIN 1A, peptide n-pY
Authors:Hwang, P.M., Li, C., Morra, M., Lillywhite, J., Gertler, F., Terhorst, C., Kay, L.E., Pawson, T., Forman-Kay, J., Li, S.-C.
Deposit date:2001-10-31
Release date:2001-11-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
1KA7
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SAP/SH2D1A BOUND TO PEPTIDE N-Y-C
Descriptor:SH2 DOMAIN PROTEIN 1A, peptide n-Y-c
Authors:Hwang, P.M., Li, C., Morra, M., Lillywhite, J., Gertler, F., Terhorst, C., Kay, L.E., Pawson, T., Forman-Kay, J., Li, S.-C.
Deposit date:2001-10-31
Release date:2001-11-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
2MX4
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NMR STRUCTURE OF PHOSPHORYLATED 4E-BP2
Descriptor:Eukaryotic translation initiation factor 4E-binding protein 2
Authors:Bah, A., Forman-Kay, J., Vernon, R., Siddiqui, Z., Krzeminski, M., Muhandiram, R., Zhao, C., Sonenberg, N., Kay, L.
Deposit date:2014-12-10
Release date:2015-01-07
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
2K6D
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CIN85 SH3-C DOMAIN IN COMPLEX WITH UBIQUITIN
Descriptor:SH3 domain-containing kinase-binding protein 1, Ubiquitin
Authors:Forman-Kay, J., Bezsonova, I.
Deposit date:2008-07-07
Release date:2008-08-19
Last modified:2018-07-04
Method:SOLUTION NMR
Cite:Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.
Biochemistry, 47, 2008
2RPN
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A CRUCIAL ROLE FOR HIGH INTRINSIC SPECIFICITY IN THE FUNCTION OF YEAST SH3 DOMAINS
Descriptor:Actin-binding protein, Actin-regulating kinase 1
Authors:Stollar, E.J., Garcia, B., Chong, A., Forman-Kay, J., Davidson, A.
Deposit date:2008-06-12
Release date:2009-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p
J.Biol.Chem., 284, 2009
3V7D
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CRYSTAL STRUCTURE OF SCSKP1-SCCDC4-PSIC1 PEPTIDE COMPLEX
Descriptor:Suppressor of kinetochore protein 1, Cell division control protein 4, Protein SIC1
Authors:Tang, X., Orlicky, S., Mittag, T., Csizmok, V., Pawson, T., Forman-Kay, J., Sicheri, F., Tyers, M.
Deposit date:2011-12-20
Release date:2012-05-02
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
1ODY
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HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
Descriptor:HIV-1 PROTEASE, 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE
Authors:Kervinen, J., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1998-07-13
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
2ER0
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES
Descriptor:ENDOTHIAPEPSIN, L364,099
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2ER9
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.
Descriptor:ENDOTHIAPEPSIN, L363,564
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2FMB
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EIAV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
Descriptor:EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE, 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE
Authors:Kervinen, J., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1998-07-13
Release date:1999-01-13
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
4ER4
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HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
Descriptor:ENDOTHIAPEPSIN, H-142
Authors:Foundling, S.I., Watson, F.E., Szelke, M., Blundell, T.L.
Deposit date:1991-01-05
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
4FIV
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FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE
Authors:Kervinen, J., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1998-07-15
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
1FMB
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EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793
Descriptor:EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL
Authors:Wlodawer, A., Gustchina, A., Zdanov, A., Kervinen, J.
Deposit date:1996-02-27
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of equine infectious anemia virus proteinase complexed with an inhibitor.
Protein Sci., 5, 1996
1PFZ
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PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM
Descriptor:PROPLASMEPSIN II, GLYCEROL
Authors:Bernstein, N.K., Cherney, M.M., Loetscher, H., Ridley, R.G., James, M.N.G.
Deposit date:1998-07-07
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nat.Struct.Biol., 6, 1999
1HXB
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HIV-1 PROTEINASE COMPLEXED WITH RO 31-8959
Descriptor:HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Graves, B.J., Hatada, M.H., Crowther, R.L.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34, 1991