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1C3I
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HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., Kammlott, R.U., Crowther, R.L., Birktoft, J.J., Dunten, P., Engler, J.E.
Deposit date:1999-07-27
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1Z8D
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CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASE A WITH AMP AND GLUCOSE
Descriptor:Glycogen phosphorylase, muscle form, ALPHA-D-GLUCOSE, ...
Authors:Lukacs, C.M., Oikonomakos, N.G., Crowther, R.L., Hong, L.N., Kammlott, R.U., Levin, W., Li, S., Liu, C.M., Lucas-McGady, D., Pietranico, S., Reik, L.
Deposit date:2005-03-30
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-state and R-state features.
Proteins, 63, 2006
4IPF
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THE 1.7A CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH RO5045337
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION
Authors:Graves, B.J., Lukacs, C., Kammlott, R.U., Crowther, R.
Deposit date:2013-01-09
Release date:2013-02-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.
Cancer Res., 73, 2013
4J3E
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THE 1.9A CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH NUTLIN-3A
Descriptor:E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION
Authors:Graves, B.J., Lukacs, C.M., Kammlott, R.U., Crowther, R.
Deposit date:2013-02-05
Release date:2013-04-24
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
1C8T
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HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., el-Kabbani, O., Dunten, P., Crowther, R.L.
Deposit date:1999-07-29
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
2FVD
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CYCLIN DEPENDENT KINASE 2 (CDK2) WITH DIAMINOPYRIMIDINE INHIBITOR
Descriptor:Cell division protein kinase 2, (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE
Authors:Crowther, R.L., Lukacs, C.M., Kammlott, R.U.
Deposit date:2006-01-30
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
J.Med.Chem., 49, 2006
3LE6
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THE STRUCTURE OF CYCLIN DEPENDENT KINASE 2 (CKD2) WITH A PYRAZOLOBENZODIAZEPINE INHIBITOR
Descriptor:Cell division protein kinase 2, 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine
Authors:Lukacs, C.M., Swain, A., Crowther, R.L., Kammlott, R.U., Liu, J.J.
Deposit date:2010-01-14
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010