Author results

1A46
  • Download 1a46
  • View 1a46
Molmil generated image of 1a46
THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.
Deposit date:1998-02-11
Release date:1998-05-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42, 1999
1A5G
  • Download 1a5g
  • View 1a5g
Molmil generated image of 1a5g
HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:St Charles, R., Tulinsky, A., Kahn, M.
Deposit date:1998-02-16
Release date:1998-05-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42, 1999
1A61
  • Download 1a61
  • View 1a61
Molmil generated image of 1a61
THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.
Deposit date:1998-03-05
Release date:1998-06-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42, 1999
1B5G
  • Download 1b5g
  • View 1b5g
Molmil generated image of 1b5g
HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN
Descriptor:ALPHA-THROMBIN, HIRUGEN, [[[(4S,5S)-4-[[(3S,6S,8aR)-6-azanyl-5-oxo-6-(phenylmethyl)-1,2,3,7,8,8a-hexahydroindolizin-3-yl]carbonylamino]-5-(1,3-benzothiazol-2-yl)-5-hydroxy-pentyl]amino]-azanyl-methylidene]azanium, ...
Authors:St Charles, R., Tulinsky, A., Kahn, M.
Deposit date:1998-03-05
Release date:1998-05-27
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42, 1999
3KJF
  • Download 3kjf
  • View 3kjf
Molmil generated image of 3kjf
CASPASE 3 BOUND TO A COVALENT INHIBITOR
Descriptor:Caspase-3, (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJN
  • Download 3kjn
  • View 3kjn
Molmil generated image of 3kjn
CASPASE 8 BOUND TO A COVALENT INHIBITOR
Descriptor:Caspase-8, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJQ
  • Download 3kjq
  • View 3kjq
Molmil generated image of 3kjq
CASPASE 8 WITH COVALENT INHIBITOR
Descriptor:Caspase-8, (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
1FPC
  • Download 1fpc
  • View 1fpc
Molmil generated image of 1fpc
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Descriptor:thrombin, Hirudin, amino{[(4S)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-10-16
Release date:1995-02-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Active-site mimetic inhibition of thrombin.
Acta Crystallogr.,Sect.D, 51, 1995
3HAT
  • Download 3hat
  • View 3hat
Molmil generated image of 3hat
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-10-16
Release date:1995-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Active-site mimetic inhibition of thrombin.
Acta Crystallogr.,Sect.D, 51, 1995