Author results

6H06
  • Download 6h06
  • View 6h06
Molmil generated image of 6h06
FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1, HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1, Microtubule-associated protein tau, ...
Authors:Juraszek, J., Steinbacher, S.
Deposit date:2018-07-06
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Acta Neuropathol Commun, 6, 2018
6H0E
  • Download 6h0e
  • View 6h0e
Molmil generated image of 6h0e
FAB DMCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1, Microtubule-associated protein tau, GLYCEROL
Authors:Juraszek, J., Steinbacher, S.
Deposit date:2018-07-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Acta Neuropathol Commun, 6, 2018
6GK7
  • Download 6gk7
  • View 6gk7
Molmil generated image of 6gk7
CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-27.1, DOUBLE MUTANT (S31Y, T100I) OF CBTAU-27.1, IN COMPLEX WITH TAU PEPTIDE A8119B (RESIDUES 299-318)
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318, CHLORIDE ION
Authors:Steinbacher, S., Mrosek, M., Juraszek, J.
Deposit date:2018-05-18
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6GK8
  • Download 6gk8
  • View 6gk8
Molmil generated image of 6gk8
CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-28.1, DOUBLE MUTANT (S32R, E35K) OF CBTAU-28.1, IN COMPLEX WITH TAU PEPTIDE A7731 (RESIDUES 52-71)
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71), CHLORIDE ION
Authors:Steinbacher, S., Mrosek, M., Juraszek, J.
Deposit date:2018-05-18
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
5W5S
  • Download 5w5s
  • View 5w5s
Molmil generated image of 5w5s
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141019 (P5)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-ZCL-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-15
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.284 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W5U
  • Download 5w5u
  • View 5w5u
Molmil generated image of 5w5u
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141037 (P4)
Descriptor:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.461 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6I
  • Download 5w6i
  • View 5w6i
Molmil generated image of 5w6i
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141046 (P3)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6R
  • Download 5w6r
  • View 5w6r
Molmil generated image of 5w6r
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141099 (P6)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.731 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6T
  • Download 5w6t
  • View 5w6t
Molmil generated image of 5w6t
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP151070 (P7)
Descriptor:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-ZCL-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6U
  • Download 5w6u
  • View 5w6u
Molmil generated image of 5w6u
CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP121068 (P2)
Descriptor:Hemagglutinin, ACE-ARG-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.878 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5ZV3
  • Download 5zv3
  • View 5zv3
Molmil generated image of 5zv3
CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-28.1 IN COMPLEX WITH ITS TAU PEPTIDE
Descriptor:Peptide from Microtubule-associated protein tau, Heavy chain of antibody CBTAU28.1, Light chain (kappa) of antibody CBTAU28.1
Authors:Zhang, H., Wilson, I.A.
Deposit date:2018-05-09
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6CF7
  • Download 6cf7
  • View 6cf7
Molmil generated image of 6cf7
CRYSTAL STRUCTURE OF THE A/SOLOMON ISLANDS/3/2006(H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE JNJ4796
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kadam, R.U., Wilson, I.A.
Deposit date:2018-02-13
Release date:2019-02-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science, 363, 2019
6CFG
  • Download 6cfg
  • View 6cfg
Molmil generated image of 6cfg
CRYSTAL STRUCTURE OF THE A/VIETNAM/1203/2004 (H5N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE JNJ4796
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, N-[2-(2-{4-[(R)-(2-methyl-2H-tetrazol-5-yl)(phenyl)methyl]piperazine-1-carbonyl}pyridin-4-yl)-1,3-benzoxazol-5-yl]acetamide, ...
Authors:Kadam, R.U., Wilson, I.A.
Deposit date:2018-02-14
Release date:2019-02-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science, 363, 2019
6DCV
  • Download 6dcv
  • View 6dcv
Molmil generated image of 6dcv
CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1
Descriptor:Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab, GLYCEROL
Authors:Zhu, X., Zhang, H., Wilson, I.A.
Deposit date:2018-05-08
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6DCW
  • Download 6dcw
  • View 6dcw
Molmil generated image of 6dcw
CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1 FAB IN COMPLEX WITH A HUMAN TAU PEPTIDE
Descriptor:Light chain of CBTAU27.1 Fab, Heavy chain of CBTAU27.1 Fab, tau peptide
Authors:Zhu, X., Zhang, H., Wilson, I.A.
Deposit date:2018-05-08
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
4J23
  • Download 4j23
  • View 4j23
Molmil generated image of 4j23
LOW RESOLUTION CRYSTAL STRUCTURE OF THE FGFR2D2D3/FGF1/SR128545 COMPLEX
Descriptor:Fibroblast growth factor receptor 2, Fibroblast growth factor 1
Authors:Kudlinzki, D., Saxena, K., Sreeramulu, S., Schieborr, U., Dreyer, M., Schreuder, H., Schwalbe, H.
Deposit date:2013-02-04
Release date:2014-02-19
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.882 Å)
Cite:Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer Cell, 23, 2013
4NM4
  • Download 4nm4
  • View 4nm4
Molmil generated image of 4nm4
CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043
Descriptor:Antibody CR8043, Light Chain, Heavy Chain, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NM8
  • Download 4nm8
  • View 4nm8
Molmil generated image of 4nm8
CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043 BOUND TO H3 INFLUENZA HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 Chain, Hemagglutinin HA2 Chain, Antibody CR8043, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (4.0041 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014