Author results

3GT8
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CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP
Descriptor:Epidermal growth factor receptor, Unknown peptide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jura, N., Endres, N.F., Engel, K., Deindl, S., Das, R., Lamers, M.H., Wemmer, D.E., Zhang, X., Kuriyan, J.
Deposit date:2009-03-27
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Cell(Cambridge,Mass.), 137, 2009
3KEX
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CRYSTAL STRUCTURE OF THE CATALYTICALLY INACTIVE KINASE DOMAIN OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3)
Descriptor:Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
5WNO
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CRYSTAL STRUCTURE OF C. ELEGANS LET-23 KINASE DOMAIN COMPLEXED WITH AMP-PNP
Descriptor:Receptor tyrosine-protein kinase let-23, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Liu, L., Thaker, T.M., Jura, N.
Deposit date:2017-08-01
Release date:2018-01-31
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
Structure, 26, 2018
2RF9
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFD
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1, SULFATE ION
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFE
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
4OTW
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HER3 PSEUDOKINASE DOMAIN BOUND TO BOSUTINIB
Descriptor:Receptor tyrosine-protein kinase erbB-3, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
Authors:Littlefield, P., Jura, N.
Deposit date:2014-02-14
Release date:2014-04-02
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase.
Chem.Biol., 21, 2014
4RIW
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIX
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIY
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-E909G MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
5CNN
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CRYSTAL STRUCTURE OF THE EGFR KINASE DOMAIN MUTANT I682Q
Descriptor:Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Kovacs, E., Das, R., Mirza, A., Jura, N., Barros, T., Kuriyan, J.
Deposit date:2015-07-17
Release date:2015-07-29
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Mol.Cell.Biol., 35, 2015
5CNO
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CRYSTAL STRUCTURE OF THE EGFR KINASE DOMAIN MUTANT V924R
Descriptor:Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Kovacs, E., Das, R., Mirza, A., Jura, N., Barros, T., Kuriyan, J.
Deposit date:2015-07-17
Release date:2015-07-29
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Mol.Cell.Biol., 35, 2015
6CNI
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CRYSTAL STRUCTURE OF H105A PGAM5 DIMER
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, SODIUM ION, ...
Authors:Ruiz, K., Agnew, C., Jura, N.
Deposit date:2018-03-08
Release date:2019-02-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Nat Commun, 10, 2019
6CNL
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CRYSTAL STRUCTURE OF H105A PGAM5 DODECAMER
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, PGAM5 Multimerization Motif Peptide, ...
Authors:Ruiz, K., Agnew, C., Jura, N.
Deposit date:2018-03-08
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Nat Commun, 10, 2019