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3CVM
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BU of 3cvm by Molmil
High resolution structure of a stable Plasminogen activator inhibitor type-1 in its protease cleaved form
Descriptor: Plasminogen activator inhibitor 1
Authors:Jensen, J.K, Gettins, P.G.W.
Deposit date:2008-04-18
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling.
Protein Sci., 17, 2008
3Q02
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BU of 3q02 by Molmil
Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Plasminogen activator inhibitor 1, ...
Authors:Jensen, J.K, Morth, J.P.
Deposit date:2010-12-15
Release date:2011-06-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability.
J.Biol.Chem., 286, 2011
3Q03
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BU of 3q03 by Molmil
Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.
Descriptor: CHLORIDE ION, Plasminogen activator inhibitor 1, ZINC ION
Authors:Jensen, J.K, Morth, J.P.
Deposit date:2010-12-15
Release date:2011-06-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6401 Å)
Cite:Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability.
J.Biol.Chem., 286, 2011
5LHR
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BU of 5lhr by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
Descriptor: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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BU of 5lhp by Molmil
The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHN
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BU of 5lhn by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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BU of 5lhq by Molmil
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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BU of 5lhs by Molmil
The ligand free catalytic domain of murine urokinase-type plasminogen activator
Descriptor: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LYO
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BU of 5lyo by Molmil
Crystal structure of the zymogen matriptase catalytic domain
Descriptor: SULFATE ION, Suppressor of tumorigenicity 14 protein
Authors:Hong, Z, Jensen, J.K.
Deposit date:2016-09-28
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors.
J.Biol.Chem., 294, 2019
5EZD
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BU of 5ezd by Molmil
Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1
Descriptor: ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION
Authors:Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K.
Deposit date:2015-11-26
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
4M8D
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BU of 4m8d by Molmil
Crystal structure of an isatin hydrolase bound to product analogue thioisatinate
Descriptor: CALCIUM ION, MANGANESE (II) ION, Putative uncharacterized protein, ...
Authors:Bjerregaard-Andersen, K, Sommer, T, Jensen, J.K, Jochimsen, B, Etzerodt, M, Morth, J.P.
Deposit date:2013-08-13
Release date:2014-06-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A proton wire and water channel revealed in the crystal structure of isatin hydrolase.
J.Biol.Chem., 289, 2014
2MSX
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BU of 2msx by Molmil
The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Inhibitor 1 reveals an unexpected PAN/apple domain-type fold
Descriptor: Kunitz-type protease inhibitor 1
Authors:Hong, Z, Nowakowski, M.E, Spronk, C, Petersen, S.V, Petersen, J.S, Kozminski, W, Mulder, F, Jensen, J.K.
Deposit date:2014-08-09
Release date:2014-12-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold.
Biochem.J., 466, 2015
4J0N
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BU of 4j0n by Molmil
Crystal structure of a manganese dependent isatin hydrolase
Descriptor: CALCIUM ION, Isatin hydrolase B, MANGANESE (II) ION, ...
Authors:Bjerregaard-Andersen, K, Sommer, T, Jensen, J.K, Jochimsen, B, Etzerodt, M, Morth, J.P.
Deposit date:2013-01-31
Release date:2013-02-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A proton wire and water channel revealed in the crystal structure of isatin hydrolase.
J.Biol.Chem., 289, 2014
6EHG
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BU of 6ehg by Molmil
complement component C3b in complex with a nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R.
Deposit date:2017-09-13
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
4X1N
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BU of 4x1n by Molmil
The crystal structure of mupain-1-16 in complex with murinised human uPA at pH7.4
Descriptor: Urokinase-type plasminogen activator, mupain-1-16, piperidine-1-carboximidamide
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-25
Release date:2015-03-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
Plos One, 9, 2014
4X0W
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BU of 4x0w by Molmil
The crystal structure of mupain-1-17 in complex with murinised human uPA
Descriptor: SULFATE ION, Urokinase-type plasminogen activator, mupain-1-17, ...
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-24
Release date:2015-10-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues.
Int.J.Biochem.Cell Biol., 62, 2015
4X1P
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BU of 4x1p by Molmil
The crystal structure of mupain-1-17 in complex with murinised human uPA at pH4.6
Descriptor: MUPAIN-1-17, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-25
Release date:2015-10-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues.
Int.J.Biochem.Cell Biol., 62, 2015
4X1Q
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BU of 4x1q by Molmil
The crystal structure of mupain-1 in complex with murinised human uPA at pH7.4
Descriptor: Urokinase-type plasminogen activator, mupain-1
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-25
Release date:2015-03-25
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
Plos One, 9, 2014
4X1S
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BU of 4x1s by Molmil
The crystal structure of mupain-1-16-D9A in complex with murinised human uPA at pH7.4
Descriptor: Urokinase-type plasminogen activator, mupain-1-16, piperidine-1-carboximidamide
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-25
Release date:2015-10-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
Plos One, 9, 2014
4X1R
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BU of 4x1r by Molmil
The crystal structure of mupain-1-12 in complex with murinised human uPA at pH7.4
Descriptor: 1-phenylguanidine, Urokinase-type plasminogen activator, mupain-1-12
Authors:Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M.
Deposit date:2014-11-25
Release date:2015-03-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
Plos One, 9, 2014
5WXP
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BU of 5wxp by Molmil
Crystal structure of uPA in complex with upain-2-3-W3A
Descriptor: ALANINE, CYSTEINE, Urokinase-type plasminogen activator chain B, ...
Authors:Jiang, L, Huang, M.
Deposit date:2017-01-08
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
5WXO
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BU of 5wxo by Molmil
Crystal structure of uPA in complex with upain-2-2-W3A
Descriptor: Urokinase-type plasminogen activator chain B, upain-2-2-W3A peptide
Authors:Jiang, L, Huang, M.
Deposit date:2017-01-08
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
5WXF
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BU of 5wxf by Molmil
Crystal structure of uPA in complex with upain-2-2
Descriptor: SULFATE ION, Urokinase-type plasminogen activator chain B, upain-2-2 peptide
Authors:Jiang, L, Huang, M.
Deposit date:2017-01-07
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
5H7V
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BU of 5h7v by Molmil
Structure of full-length extracellular domain of HAI-1 at pH 4.6
Descriptor: Kunitz-type protease inhibitor 1
Authors:Liu, M, Huang, M.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.82 Å)
Cite:The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
3OY6
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BU of 3oy6 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
Descriptor: MH036, Urokinase-type plasminogen activator
Authors:Jiang, L.G, Andreasen, P.A, Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011

 

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