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1DSX
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BU of 1dsx by Molmil
KV1.2 T1 DOMAIN, RESIDUES 33-119, T46V MUTANT
Descriptor: PROTEIN (KV1.2 VOLTAGE-GATED POTASSIUM CHANNEL)
Authors:Minor Jr, D.L, Lin, Y.-F, Mobley, B.C, Avelar, A, Jan, Y.N, Jan, L.Y, Berger, J.M.
Deposit date:2000-01-10
Release date:2000-09-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Cell(Cambridge,Mass.), 102, 2000
1QDV
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BU of 1qdv by Molmil
N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-131
Descriptor: KV1.2 VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Minor Jr, D.L, Lin, Y.-F, Mobley, B.C, Yu, M, Jan, Y.N, Jan, L.Y, Berger, J.M.
Deposit date:1999-07-10
Release date:2000-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Cell(Cambridge,Mass.), 102, 2000
1QDW
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BU of 1qdw by Molmil
N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-119
Descriptor: KV1.2 VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Minor Jr, D.L, Lin, Y.-F, Mobley, B.C, Avelar, A, Jan, Y.N, Jan, L.Y, Berger, J.M.
Deposit date:1999-07-10
Release date:2000-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Cell(Cambridge,Mass.), 102, 2000
6P49
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BU of 6p49 by Molmil
Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2
Descriptor: Anoctamin-6, CALCIUM ION
Authors:Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P46
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BU of 6p46 by Molmil
Cryo-EM structure of TMEM16F in digitonin with calcium bound
Descriptor: Anoctamin-6, CALCIUM ION
Authors:Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P47
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BU of 6p47 by Molmil
Cryo-EM structure of TMEM16F in digitonin without calcium
Descriptor: Anoctamin-6
Authors:Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P48
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BU of 6p48 by Molmil
Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1
Descriptor: Anoctamin-6, CALCIUM ION
Authors:Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
5VKQ
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BU of 5vkq by Molmil
Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, No mechanoreceptor potential C isoform L
Authors:Jin, P, Bulkley, D, Guo, Y, Zhang, W, Guo, Z, Huynh, W, Wu, S, Meltzer, S, Chen, T, Jan, L.Y, Jan, Y.-N, Cheng, Y.
Deposit date:2017-04-22
Release date:2017-06-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Nature, 547, 2017
4CQH
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BU of 4cqh by Molmil
Structure of Infrared Fluorescent Protein IFP2.0
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, BACTERIOPHYTOCHROME, SODIUM ION
Authors:Lafaye, C, Yu, D, Noirclerc-Savoye, M, Shu, X, Royant, A.
Deposit date:2014-02-17
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:An Improved Monomeric Infrared Fluorescent Protein for Neuronal and Tumour Brain Imaging.
Nat.Commun., 5, 2014
6BGJ
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BU of 6bgj by Molmil
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG
Descriptor: Anoctamin-1, CALCIUM ION
Authors:Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, L, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6BGI
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BU of 6bgi by Molmil
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc
Descriptor: Anoctamin-1, CALCIUM ION
Authors:Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, J, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
8SUR
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BU of 8sur by Molmil
TMEM16F bound with Niclosamide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ...
Authors:Feng, S, Cheng, Y.
Deposit date:2023-05-13
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
8TAG
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BU of 8tag by Molmil
TMEM16F, with Calcium and PIP2, no inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION
Authors:Feng, S, Cheng, Y.
Deposit date:2023-06-27
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
8TAI
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BU of 8tai by Molmil
TMEM16F, with Calcium and PIP2, no inhibitor, Cl2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION
Authors:Wu, H, Feng, S, Cheng, Y.
Deposit date:2023-06-27
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
8TAL
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BU of 8tal by Molmil
TMEM16F, with Calcium and PIP2, no inhibitor, Cl1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION
Authors:Wu, H, Feng, S, Cheng, Y.
Deposit date:2023-06-27
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
8SUN
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BU of 8sun by Molmil
TMEM16F 1PBC
Descriptor: 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, ...
Authors:Wu, H, Feng, S, Cheng, Y.
Deposit date:2023-05-12
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
7S8L
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BU of 7s8l by Molmil
CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
Descriptor: Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
7S8N
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BU of 7s8n by Molmil
CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
Descriptor: (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
7S8P
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BU of 7s8p by Molmil
CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134
Descriptor: Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
7S8M
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BU of 7s8m by Molmil
CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14
Descriptor: Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
7S8O
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BU of 7s8o by Molmil
CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
Descriptor: (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
7UKC
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BU of 7ukc by Molmil
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKE
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BU of 7uke by Molmil
Human Kv4.2-KChIP2 channel complex in an intermediate state, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKD
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BU of 7ukd by Molmil
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UK5
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BU of 7uk5 by Molmil
Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-03-31
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022

 

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