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2AJP
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BU of 2ajp by Molmil
Crystal structure of a human pyridoxal kinase
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyridoxal kinase, ...
Authors:Ismail, S, Dimov, S, Atanassova, A, Tempel, W, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2005-08-02
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a human pyridoxal kinase
To be Published
2AL7
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BU of 2al7 by Molmil
Structure Of Human ADP-Ribosylation Factor-Like 10C
Descriptor: ADP-ribosylation factor-like 10C, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Ismail, S, Dimov, S, Atanassova, A, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2005-08-04
Release date:2005-08-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:GTP-like conformation of GDP-bound ARL10C GTPase
To be Published
2B0O
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BU of 2b0o by Molmil
Crystal structure of UPLC1 GAP domain
Descriptor: UPLC1, ZINC ION
Authors:Ismail, S, Shen, L, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2005-09-14
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural analysis of GAP and ankyrin domains of UPLC1
To be Published
5E80
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BU of 5e80 by Molmil
The crystal structure of PDEd in complex with inhibitor-2a
Descriptor: N-(3-chloro-2-methylphenyl)-4-(3,4-dimethyl-7-oxo-2-phenyl-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Authors:Ismail, S, Fansa, E.K, Murarka, S, Wittinghofer, A.
Deposit date:2015-10-13
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of pyrazolopyridazinones as PDE delta inhibitors.
Nat Commun, 7, 2016
7AJK
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BU of 7ajk by Molmil
Crystal structure of CRYI-B Rac1 complex
Descriptor: CYFIP-related Rac1 interactor B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Yelland, T, Anh, L, Insall, R, Machesky, L, Ismail, S.
Deposit date:2020-09-29
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Structure, 29, 2021
7AJL
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BU of 7ajl by Molmil
Cyrstal structure of CYRI-B/Fam49B
Descriptor: CYFIP-related Rac1 interactor B
Authors:Yelland, T, Anh, H, Insall, R, Machesky, L, Ismail, S.
Deposit date:2020-09-29
Release date:2020-11-18
Last modified:2021-06-02
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Structure, 29, 2021
6H6A
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BU of 6h6a by Molmil
Crystal structure of UNC119 in complex with LCK peptide
Descriptor: GLY-CYS-GLY-CYS-SER-SER, GLYCEROL, MYRISTIC ACID, ...
Authors:Yelland, T, ElMaghloob, Y, McIlwraith, M, Stephen, L, Ismail, S.
Deposit date:2018-07-26
Release date:2018-09-26
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Dev.Cell, 47, 2018
7Q9Q
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BU of 7q9q by Molmil
Crystal structure of PDE6D Geranylgeranylated cystein complex
Descriptor: 1,2-ETHANEDIOL, GERAN-8-YL GERAN, O-METHYLCYSTEINE, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-11-14
Release date:2022-01-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7QJK
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BU of 7qjk by Molmil
Crystal structure of PDE6D in complex with Compound-2
Descriptor: 1,2-ETHANEDIOL, N-(phenylmethyl)pyridin-2-amine, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-12-16
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
2FG5
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BU of 2fg5 by Molmil
Crystal structure of human RAB31 in complex with a GTP analogue
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-31
Authors:Tempel, W, Wang, J, Ismail, S, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2005-12-21
Release date:2006-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystal structure of human RAB31 in complex with a GTP analogue
To be Published
2EW1
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BU of 2ew1 by Molmil
Crystal Structure of Rab30 in complex with a GTP analogue
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-30
Authors:Wang, J, Shen, Y, Ismail, S, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC)
Deposit date:2005-11-01
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of RAB30 in complex with a GTP analogue
To be Published
2F7S
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BU of 2f7s by Molmil
The crystal structure of human Rab27b bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-27B
Authors:Wang, J, Ismail, S, Shen, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC)
Deposit date:2005-12-01
Release date:2005-12-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human Rab27b
To be Published
1ZYR
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BU of 1zyr by Molmil
Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2CW0
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BU of 2cw0 by Molmil
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
7OK6
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BU of 7ok6 by Molmil
Crystal structure of UNC119B in complex with LCK peptide
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, LCK peptide, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-05-17
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms.
Biochemistry, 60, 2021
7OK7
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BU of 7ok7 by Molmil
Crystal structure of the UNC119B ARL3 complex
Descriptor: 1,2-ETHANEDIOL, ADP-ribosylation factor-like protein 3, GLYCEROL, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-05-17
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms.
Biochemistry, 60, 2021
7Q9S
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BU of 7q9s by Molmil
Crystal structure of PDE6D KRas peptide complex with Compound-1
Descriptor: 1,2-ETHANEDIOL, 2-methyl-3-(1~{H}-pyrazol-5-yl)imidazo[1,2-a]pyridine, DIMETHYL SULFOXIDE, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-11-14
Release date:2022-01-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
7Q9R
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BU of 7q9r by Molmil
Cocrystal structure of PDE6D bound to NRAS peptide
Descriptor: 1,2-ETHANEDIOL, FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ...
Authors:Yelland, T, Ismail, S.
Deposit date:2021-11-14
Release date:2022-01-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J.Med.Chem., 65, 2022
4JV6
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BU of 4jv6 by Molmil
The crystal structure of PDE6D in complex to inhibitor-1
Descriptor: 1-benzyl-2-phenyl-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Authors:Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JV8
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BU of 4jv8 by Molmil
The crystal structure of PDE6D in complex with rac-S1
Descriptor: (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Authors:Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVB
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BU of 4jvb by Molmil
Crystal structure of PDE6D in complex with the inhibitor rac-2
Descriptor: 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Authors:Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVF
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BU of 4jvf by Molmil
The Crystal structure of PDE6D in complex with the inhibitor (s)-5
Descriptor: (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Authors:Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
2AX4
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BU of 2ax4 by Molmil
Crystal structure of the kinase domain of human 3'-phosphoadenosine 5'-phosphosulphate synthetase 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2
Authors:Rabeh, W.M, Nedyalkova, L, Ismail, S, Park, H, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Structural Genomics Consortium (SGC)
Deposit date:2005-09-02
Release date:2005-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the kinase domain of PAPSS 2
To be Published
4JHP
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BU of 4jhp by Molmil
The crystal structure of the RPGR RCC1-like domain in complex with PDE6D
Descriptor: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
4JHN
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BU of 4jhn by Molmil
The crystal structure of the RPGR RCC1-like domain
Descriptor: X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013

 

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