Author results

1LR7
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CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE SUCROSE OCTASULPHATE (SOS)
Descriptor:follistatin
Authors:Innis, C.A., Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR8
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CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE D-MYO-INOSITOL HEXASULPHATE (INS6S)
Descriptor:follistatin
Authors:Innis, C.A., Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR9
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STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN
Descriptor:Follistatin
Authors:Innis, C.A., Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1VY4
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING ACYLATED TRNA-SUBSTRATES IN THE A AND P SITES.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY5
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE POST-CATALYSIS STATE OF PEPTIDE BOND FORMATION CONTAINING DIPEPTYDIL-TRNA IN THE A SITE AND DEACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY6
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY7
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
Descriptor:PROTEIN/RNA Complex
Authors:Polikanov, Y.S., Steitz, T.A., Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
3GNA
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CRYSTAL STRUCTURE OF THE RAG1 NONAMER-BINDING DOMAIN WITH DNA
Descriptor:V(D)J recombination-activating protein 1
Authors:Yin, F.F., Bailey, S., Innis, C.A., Steitz, T.A., Schatz, D.G.
Deposit date:2009-03-16
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nat.Struct.Mol.Biol., 16, 2009
3GNB
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CRYSTAL STRUCTURE OF THE RAG1 NONAMER-BINDING DOMAIN WITH DNA
Descriptor:V(D)J recombination-activating protein 1
Authors:Yin, F.F., Bailey, S., Innis, C.A., Steitz, T.A., Schatz, D.G.
Deposit date:2009-03-16
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nat.Struct.Mol.Biol., 16, 2009
3J9W
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CRYO-EM STRUCTURE OF THE BACILLUS SUBTILIS MIFM-STALLED RIBOSOME COMPLEX
Descriptor:PROTEIN/RNA Complex
Authors:Sohmen, D., Chiba, S., Shimokawa-Chiba, N., Innis, C.A., Berninghausen, O., Beckmann, R., Ito, K., Wilson, D.N.
Deposit date:2015-03-16
Release date:2015-04-29
Last modified:2015-05-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
Nat Commun, 6, 2015
4V5H
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E.COLI 70S RIBOSOME STALLED DURING TRANSLATION OF TNAC LEADER PEPTIDE.
Descriptor:Ribosome
Authors:Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R.
Deposit date:2009-10-26
Release date:2014-07-09
Last modified:2015-02-04
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural Insight Into Nascent Polypeptide Chain-Mediated Translational Stalling.
Science, 326, 2009
4V7W
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH CHLORAMPHENICOL.
Descriptor:PROTEIN/RNA Complex
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7X
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH ERYTHROMYCIN.
Descriptor:PROTEIN/RNA Complex
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-17
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Y
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH AZITHROMYCIN.
Descriptor:70S Ribosome, azithromycin
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Z
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.
Descriptor:70S Ribosome
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4ZER
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CRYSTAL STRUCTURE OF THE ONC112 ANTIMICROBIAL PEPTIDE BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, tRNAi/RNA Complex
Authors:Seefeldt, A.C., Nguyen, F., Antunes, S., Perebaskine, N., Graf, M., Arenz, S., Inampudi, K.K., Douat, C., Guichard, G., Wilson, D.N., Innis, C.A.
Deposit date:2015-04-20
Release date:2015-05-20
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.
Nat.Struct.Mol.Biol., 22, 2015
5F8K
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CRYSTAL STRUCTURE OF THE BAC7(1-16) ANTIMICROBIAL PEPTIDE BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14 type Z, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, Bac7(1-16)/RNA Complex
Authors:Seefeldt, A.C., Graf, M., Perebaskine, N., Nguyen, F., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A.
Deposit date:2015-12-09
Release date:2016-02-03
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5FDU
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CRYSTAL STRUCTURE OF THE METALNIKOWIN I ANTIMICROBIAL PEPTIDE BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14 type Z, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, Ribosome-associated inhibitor A, Metalnikowin I/RNA Complex
Authors:Seefeldt, A.C., Graf, M., Perebaskine, N., Nguyen, F., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A.
Deposit date:2015-12-16
Release date:2016-01-27
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5FDV
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CRYSTAL STRUCTURE OF THE PYRRHOCORICIN ANTIMICROBIAL PEPTIDE BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, Ribosome-associated inhibitor A, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14 type Z, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, Pyrrhocoricin/RNA Complex
Authors:Seefeldt, A.C., Graf, M., Perebaskine, N., Nguyen, F., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A.
Deposit date:2015-12-16
Release date:2016-01-27
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5JTE
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CRYO-EM STRUCTURE OF AN ERMBL-STALLED RIBOSOME IN COMPLEX WITH A-, P-, AND E-TRNA
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein S21, 50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, ErmBL, Lysine attached to A-tRNA/RNA Complex
Authors:Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmueller, H., Vaiana, A.C., Wilson, D.N.
Deposit date:2016-05-09
Release date:2016-07-20
Last modified:2016-09-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Nat Commun, 7, 2016
5JU8
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CRYO-EM STRUCTURE OF AN ERMBL-STALLED RIBOSOME IN COMPLEX WITH P-, AND E-TRNA
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein S21, 50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, 50S ribosomal protein L5, 50S ribosomal protein L6, 50S ribosomal protein L9, 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, 50S ribosomal protein L16, 50S ribosomal protein L17, 50S ribosomal protein L18, 50S ribosomal protein L19, 50S ribosomal protein L20, 50S ribosomal protein L21, 50S ribosomal protein L22, 50S ribosomal protein L23, 50S ribosomal protein L24, 50S ribosomal protein L25, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, ErmBL/RNA Complex
Authors:Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmueller, H., Vaiana, A.C., Wilson, D.N.
Deposit date:2016-05-10
Release date:2016-07-20
Last modified:2016-10-12
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Nat Commun, 7, 2016
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