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5KVL
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BU of 5kvl by Molmil
Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4
Descriptor: (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Huxford, T, King, A, Fleming, J.K, Wojciak, J.M.
Deposit date:2016-07-14
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4
To Be Published
1IKN
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BU of 1ikn by Molmil
IKAPPABALPHA/NF-KAPPAB COMPLEX
Descriptor: PROTEIN (I-KAPPA-B-ALPHA), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (NF-KAPPA-B P65 SUBUNIT)
Authors:Huxford, T, Huang, D.-B, Malek, S, Ghosh, G.
Deposit date:1998-11-13
Release date:1999-04-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
1MY7
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BU of 1my7 by Molmil
NF-kappaB p65 subunit dimerization domain homodimer N202R mutation
Descriptor: NF-kappaB p65 (RelA) subunit
Authors:Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaB alpha complex formation
J.Mol.Biol., 324, 2002
1MY5
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BU of 1my5 by Molmil
NF-kappaB p65 subunit dimerization domain homodimer
Descriptor: NF-kappaB p65 (RelA) subunit
Authors:Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/I kappaB alpha complex formation
J.Mol.Biol., 324, 2002
3I9G
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BU of 3i9g by Molmil
Crystal structure of the LT1009 (SONEPCIZUMAB) antibody Fab fragment in complex with sphingosine-1-phosphate
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, CALCIUM ION, MAGNESIUM ION, ...
Authors:Huxford, T.
Deposit date:2009-07-10
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
Proc.Natl.Acad.Sci.USA, 106, 2009
6NL6
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BU of 6nl6 by Molmil
Crystal structure of mutant B1 immunoglobulin-binding domain of Streptococcal Protein G (T16F, T18A, V21E, T25L, K28Y, V29I, K31R, Q32H, Y33L, N35K, D36H, N37Q)
Descriptor: CHLORIDE ION, Immunoglobulin G-binding protein G, ZINC ION
Authors:Huxford, T, Stec, B, Maniaci, B.
Deposit date:2019-01-08
Release date:2019-01-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Design of High-Affinity Metal-Controlled Protein Dimers.
Biochemistry, 58, 2019
8EXW
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BU of 8exw by Molmil
Drosophila melanogaster indirect flight muscle myosin II (subfragment-1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Isoform K of Myosin heavy chain, muscle, ...
Authors:Caldwell, J.T, Huxford, T, Bernstein, S.I, Stec, B.
Deposit date:2022-10-25
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Drosophila melanogaster indirect flight muscle myosin II (subfragment-1)
To Be Published
1BFS
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BU of 1bfs by Molmil
STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor: NUCLEAR FACTOR NF-KAPPA-B P50
Authors:Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1BFT
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BU of 1bft by Molmil
STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor: NUCLEAR FACTOR NF-KAPPA-B P65
Authors:Huang, D.B, Huxford, T, Chen, Y.Q, Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
6VRT
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BU of 6vrt by Molmil
LT1009 humanized antibody Fab fragment in complex with calcium
Descriptor: CALCIUM ION, SULFATE ION, Sonepcizumab antibody Fab fragment, ...
Authors:Fleming, J.K, Huxford, T.
Deposit date:2020-02-09
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.555 Å)
Cite:Ion binding properties of a naturally occurring metalloantibody
Antibodies, 9, 2020
8TKM
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BU of 8tkm by Molmil
Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 17-mer kappaB DNA from human interleukin-6 (IL-6) promoter
Descriptor: 17-mer kappaB DNA, Nuclear factor NF-kappa-B p50 subunit
Authors:Zhu, N, Mealka, M, Mitchel, S, Rogers, W.E, Huxford, T.
Deposit date:2023-07-25
Release date:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA.
Biomolecules, 13, 2023
8TKN
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BU of 8tkn by Molmil
Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 10-mer kappaB DNA from human Neutrophil Gelatinase-associated Lipocalin (NGAL) promoter
Descriptor: DNA A, DNA B, Nuclear factor NF-kappa-B p50 subunit
Authors:Zhu, N, Mealka, M, Mitchel, S, Rogers, W.E, Huxford, T.
Deposit date:2023-07-25
Release date:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA.
Biomolecules, 13, 2023
8TKL
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BU of 8tkl by Molmil
Murine NF-kappaB p50 Rel Homology Region homodimer in complex with a Test 16-mer kappaB-like DNA
Descriptor: Nuclear factor NF-kappa-B p50 subunit, Test 17-mer kappaB-like DNA
Authors:Mitchel, S, Mealka, M, Rogers, W.E, Milani, C, Acuna, L.M, Huxford, T.
Deposit date:2023-07-25
Release date:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA.
Biomolecules, 13, 2023
5W1A
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BU of 5w1a by Molmil
The first X-ray crystal structure of an insect muscle myosin. Drosophila melanogaster, skeletal muscle myosin II, an embryonic isoform, subfragment-1
Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ...
Authors:Caldwell, J.T, Bernstein, S.I, Huxford, T.
Deposit date:2017-06-02
Release date:2018-06-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.227 Å)
Cite:X-ray crystallographic and molecular dynamic analyses of Drosophila melanogaster embryonic muscle myosin define domains responsible for isoform-specific properties.
J.Mol.Biol., 2019
4ZF8
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BU of 4zf8 by Molmil
Cytochrome P450 pentamutant from BM3 with bound Metyrapone
Descriptor: Bifunctional P-450/NADPH-P450 reductase, METYRAPONE, NICKEL (II) ION, ...
Authors:Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZFB
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BU of 4zfb by Molmil
Cytochrome P450 pentamutant from BM3 bound to Palmitic Acid
Descriptor: 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ...
Authors:Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZFA
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BU of 4zfa by Molmil
Cytochrome P450 wild type from BM3 with bound PEG
Descriptor: 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ...
Authors:Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.765 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZF6
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BU of 4zf6 by Molmil
Cytochrome P450 pentamutant from BM3 with bound PEG
Descriptor: 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ...
Authors:Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.773 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
1K3Z
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BU of 1k3z by Molmil
X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex
Descriptor: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
1OY3
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BU of 1oy3 by Molmil
CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
Descriptor: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Malek, S, Huang, D.B, Huxford, T, Ghosh, S, Ghosh, G.
Deposit date:2003-04-03
Release date:2003-05-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
3NOW
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BU of 3now by Molmil
UNC-45 from Drosophila melanogaster
Descriptor: UNC-45 protein, SD10334p
Authors:Lee, C.F, Hauenstein, A.V, Fleming, J.K, Gasper, W.C, Engelke, V, Banumathi, S, Bernstein, S.I, Huxford, T.
Deposit date:2010-06-25
Release date:2011-03-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.992 Å)
Cite:X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster.
Structure, 19, 2011
3PMZ
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BU of 3pmz by Molmil
Crystal Structure of the Complex of Acetylcholine Binding Protein and d-tubocurarine
Descriptor: (1beta,1'alpha)-7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium, MAGNESIUM ION, Soluble acetylcholine receptor
Authors:Talley, T.T, Harel, M, Yamauchi, J.G, Radic, Z, Hansen, S, Huxford, T, Taylor, P.W.
Deposit date:2010-11-18
Release date:2011-10-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:The Curare Alkaloids: Analyzing the Poses of Complexes with the Acetylcholine Binding Protein in Relation to Structure and Binding Energies
To be Published
3PEO
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BU of 3peo by Molmil
Crystal structure of acetylcholine binding protein complexed with metocurine
Descriptor: 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyltubocuraran-2,2'-diium, Soluble acetylcholine receptor
Authors:Talley, T.T, Harel, M, Yamauchi, G.J, Radic, Z, Hansen, S, Huxford, T, Taylor, P.W.
Deposit date:2010-10-27
Release date:2011-10-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The curare alkaloids: analyzing the poses of complexes with the acetylcholine binding protein in relation to structure and binding energetics
To be Published
3QCT
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BU of 3qct by Molmil
Crystal structure of the humanized apo LT3015 anti-lysophosphatidic acid antibody Fab fragment
Descriptor: LT3015 antibody Fab fragment, heavy chain, light chain, ...
Authors:Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T.
Deposit date:2011-01-17
Release date:2011-03-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1493 Å)
Cite:Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011
3QCU
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BU of 3qcu by Molmil
Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (14:0)
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, LT3015 antibody Fab fragment, heavy chain, ...
Authors:Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T.
Deposit date:2011-01-17
Release date:2011-03-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011

 

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