Author results

1NL1
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BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Huang, M., Huang, G., Furie, B., Seaton, B., Furie, B.C.
Deposit date:2003-01-06
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nat.Struct.Biol., 10, 2003
1NL2
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BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM AND LYSOPHOSPHOTIDYLSERINE
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Huang, M., Huang, G., Furie, B., Seaton, B., Furie, B.C.
Deposit date:2003-01-06
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nat.Struct.Biol., 10, 2003
4Y86
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CRYSTAL STRUCTURE OF PDE9 IN COMPLEX WITH RACEMIC INHIBITOR C33
Descriptor:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, ZINC ION, ...
Authors:Huang, M.
Deposit date:2015-02-16
Release date:2015-09-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Mol.Pharmacol., 88, 2015
4Y87
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CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 9 IN COMPLEX WITH (R)-C33 (6-{[(1R)-1-(4-CHLOROPHENYL)ETHYL]AMINO}-1-CYCLOPENTYL-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE)
Descriptor:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, ZINC ION, ...
Authors:Huang, M.
Deposit date:2015-02-16
Release date:2015-09-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Mol.Pharmacol., 88, 2015
4Y8C
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CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 9 IN COMPLEX WITH (S)-C33
Descriptor:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, ZINC ION, ...
Authors:Huang, M.
Deposit date:2015-02-16
Release date:2015-09-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Mol.Pharmacol., 88, 2015
1AHW
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A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)
Descriptor:IMMUNOGLOBULIN FAB 5G9 (LIGHT CHAIN), IMMUNOGLOBULIN FAB 5G9 (HEAVY CHAIN), TISSUE FACTOR
Authors:Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A.
Deposit date:1997-04-10
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.5G9 complex.
J.Mol.Biol., 275, 1998
1F6B
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CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX
Descriptor:SAR1, MAGNESIUM ION, SULFATE ION, ...
Authors:Huang, M., Wilson, I.A., Balch, W.E.
Deposit date:2000-06-21
Release date:2002-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export.
J.Cell Biol., 155, 2001
1FGN
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MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR
Descriptor:IMMUNOGLOBULIN FAB 5G9
Authors:Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A.
Deposit date:1997-04-10
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.5G9 complex.
J.Mol.Biol., 275, 1998
1J9C
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CRYSTAL STRUCTURE OF TISSUE FACTOR-FACTOR VIIA COMPLEX
Descriptor:Tissue factor, factor VIIa light chain, factor VIIa heavy chain, ...
Authors:Huang, M., Ruf, W., Edgington, T.S., Wilson, I.A.
Deposit date:2001-05-24
Release date:2004-07-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand Induced Conformational Transitions of Tissue Factor. Crystal Structure of the Tissue Factor:Factor VIIa Complex.
To be Published
1NL0
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CRYSTAL STRUCTURE OF HUMAN FACTOR IX GLA DOMAIN IN COMPLEX OF AN INHIBITORY ANTIBODY, 10C12
Descriptor:anti-factor IX antibody, 10C12, chain L, ...
Authors:Huang, M., Furie, B.C., Furie, B.
Deposit date:2003-01-06
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Calcium-stabilized Human Factor IX Gla Domain Bound to a Conformation-specific Anti-factor IX Antibody.
J.Biol.Chem., 279, 2004
1TFH
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EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR
Descriptor:HUMAN TISSUE FACTOR
Authors:Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A.
Deposit date:1997-04-10
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.5G9 complex.
J.Mol.Biol., 275, 1998
2FD6
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STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR IN COMPLEX WITH UROKINASE RECEPTOR AND AN ANTI-UPAR ANTIBODY AT 1.9 A
Descriptor:Urokinase-type plasminogen activator, L chain of Fab of ATN-615 anti-uPAR antibody, H chain of Fab of ATN-615 anti-uPAR antibody, ...
Authors:Huang, M., Huai, Q., Li, Y.
Deposit date:2005-12-13
Release date:2006-02-21
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311, 2006
2PQS
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CRYSTAL STRUCTURE OF THE BOVINE LACTADHERIN C2 DOMAIN
Descriptor:Lactadherin
Authors:Huang, M., Furie, B.C.
Deposit date:2007-05-02
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
J.Mol.Biol., 371, 2007
3BT1
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, Urokinase plasminogen activator surface receptor, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
3BT2
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
3LAQ
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STRUCTURE-BASED ENGINEERING OF SPECIES SELECTIVITY IN THE UPA-UPAR INTERACTION
Descriptor:Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Huang, M.
Deposit date:2010-01-06
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy.
J.Biol.Chem., 285, 2010
1XNZ
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CRYSTAL STRUCTURE OF MN(II) FORM OF E. COLI. METHIONINE AMINOPEPTIDASE IN COMPLEX WITH 5-(2-CHLOROPHENYL)FURAN-2-CARBOXYLIC ACID
Descriptor:Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ...
Authors:Ye, Q.-Z., Xie, S.-X., Huang, M., Huang, W.-J., Lu, J.-P., Ma, Z.-Q.
Deposit date:2004-10-05
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
J.Am.Chem.Soc., 126, 2004
2I2Z
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HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND ASPIRIN
Descriptor:Serum albumin, MYRISTIC ACID, 2-HYDROXYBENZOIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2I30
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HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND SALICYLIC ACID
Descriptor:Serum albumin, 2-HYDROXYBENZOIC ACID, MYRISTIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2NWN
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NEW PHARMACOPHORE FOR SERINE PROTEASE INHIBITION REVEALED BY CRYSTAL STRUCTURE OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR COMPLEXED WITH A CYCLIC PEPTIDYL INHIBITOR, UPAIN-1
Descriptor:Plasminogen activator, urokinase, upain-1
Authors:Zhao, G., Yuan, C., Wind, T., Andreasen, P.A., Huang, Z., Huang, M., Structural Genomics Consortium (SGC)
Deposit date:2006-11-16
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
2O8T
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CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, PENTAETHYLENE GLYCOL, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8U
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CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, BENZAMIDINE, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8W
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CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2FA9
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THE CRYSTAL STRUCTURE OF SAR1[H79G]-GDP PROVIDES INSIGHT INTO THE COAT-CONTROLLED GTP HYDROLYSIS IN THE DISASSEMBLY OF COP II
Descriptor:GTP-binding protein SAR1b, MAGNESIUM ION, SULFATE ION, ...
Authors:Rao, Y., Huang, M., Yuan, C., Bian, C., Hou, X.
Deposit date:2005-12-07
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP II
Chin.J.Struct.Chem., 25, 2006
2FMX
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AN OPEN CONFORMATION OF SWITCH I REVEALED BY SAR1-GDP CRYSTAL STRUCTURE AT LOW MG(2+)
Descriptor:GTP-binding protein SAR1b, SULFATE ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Rao, Y., Bian, C., Yuan, C., Li, Y., Huang, M.
Deposit date:2006-01-10
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)
Biochem.Biophys.Res.Commun., 348, 2006