Author results

4K33
  • Download 4k33
  • View 4k33
Molmil generated image of 4k33
CRYSTAL STRUCTURE OF FGF RECEPTOR 3 (FGFR3) KINASE DOMAIN HARBORING THE K650E MUTATION, A GAIN-OF-FUNCTION MUTATION RESPONSIBLE FOR THANATOPHORIC DYSPLASIA TYPE II AND SPERMATOCYTIC SEMINOMA
Descriptor:Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION
Authors:Huang, Z., Chen, H., Mohammadi, M.
Deposit date:2013-04-10
Release date:2013-09-11
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.3405 Å)
Cite:Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation.
Structure, 21, 2013
4QQ5
  • Download 4qq5
  • View 4qq5
Molmil generated image of 4qq5
CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE HARBORING THE V550L GATE-KEEPER MUTATION IN COMPLEX WITH FIIN-2, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR CAPABLE OF OVERCOMING FGFR KINASE GATE-KEEPER MUTATIONS
Descriptor:Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-26
Release date:2014-10-29
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQJ
  • Download 4qqj
  • View 4qqj
Molmil generated image of 4qqj
CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE DOMAIN HARBORING THE V550L GATE-KEEPER MUTATION
Descriptor:Fibroblast growth factor receptor 4, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-27
Release date:2014-10-29
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.682 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQT
  • Download 4qqt
  • View 4qqt
Molmil generated image of 4qqt
CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 TYROSINE KINASE DOMAIN
Descriptor:Fibroblast growth factor receptor 4, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-29
Release date:2014-10-29
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QRC
  • Download 4qrc
  • View 4qrc
Molmil generated image of 4qrc
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 4 IN COMPLEX WITH PONATINIB
Descriptor:Fibroblast growth factor receptor 4, SULFATE ION, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-30
Release date:2014-10-29
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
5EG3
  • Download 5eg3
  • View 5eg3
Molmil generated image of 5eg3
CRYSTAL STRUCTURE OF THE ACTIVATED FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN IN COMPLEX WITH THE CSH2 DOMAIN OF PHOSPHOLIPASE C GAMMA (PLCGAMMA)
Descriptor:Fibroblast growth factor receptor 2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Huang, Z., Li, X., Mohammadi, M.
Deposit date:2015-10-26
Release date:2016-02-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.606 Å)
Cite:Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.
Mol.Cell, 61, 2016
3DJA
  • Download 3dja
  • View 3dja
Molmil generated image of 3dja
CRYSTAL STRUCTURE OF CPAF SOLVED WITH MAD
Descriptor:Protein CT_858
Authors:Chai, J., Huang, Z.
Deposit date:2008-06-22
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DOR
  • Download 3dor
  • View 3dor
Molmil generated image of 3dor
CRYSTAL STRUCTURE OF MATURE CPAF
Descriptor:Protein CT_858, SULFATE ION
Authors:Chai, J., Huang, Z.
Deposit date:2008-07-06
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DPM
  • Download 3dpm
  • View 3dpm
Molmil generated image of 3dpm
STRUCTURE OF MATURE CPAF COMPLEXED WITH LACTACYSTIN
Descriptor:Protein CT_858, N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine
Authors:Chai, J., Huang, Z.
Deposit date:2008-07-09
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DPN
  • Download 3dpn
  • View 3dpn
Molmil generated image of 3dpn
CRYSTAL STRUCTURE OF CPAF S499A MUTANT
Descriptor:Protein CT_858
Authors:Chai, J., Huang, Z.
Deposit date:2008-07-09
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
5Y2F
  • Download 5y2f
  • View 5y2f
Molmil generated image of 5y2f
HUMAN SIRT6 IN COMPLEX WITH ALLOSTERIC ACTIVATOR MDL-801
Descriptor:NAD-dependent protein deacetylase sirtuin-6, 9-mer peptide QTARKSTGG, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ...
Authors:Zhang, J., Huang, Z., Song, K.
Deposit date:2017-07-25
Release date:2018-11-07
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Identification of a cellularly active SIRT6 allosteric activator.
Nat. Chem. Biol., 14, 2018
1Z7I
  • Download 1z7i
  • View 1z7i
Molmil generated image of 1z7i
2'-ME-SE DERIVITATION OF A-DNA OCTAMER G(UMSE)GTACAC
Descriptor:5'-D(*GP*(UMS)P*GP*TP*AP*CP*AP*C)-3', SPERMINE
Authors:Huang, Z., Carrasco, N., Jiang, J.
Deposit date:2005-03-24
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Selenium derivatization of nucleic acids for crystallography.
Nucleic Acids Res., 35, 2007
3CXB
  • Download 3cxb
  • View 3cxb
Molmil generated image of 3cxb
CRYSTAL STRUCTURE OF SIFA AND SKIP
Descriptor:Protein sifA, Pleckstrin homology domain-containing family M member 2
Authors:Huang, Z., Chai, J.
Deposit date:2008-04-24
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation
Cell Host Microbe, 4, 2008
3GCG
  • Download 3gcg
  • View 3gcg
Molmil generated image of 3gcg
CRYSTAL STRUCTURE OF MAP AND CDC42 COMPLEX
Descriptor:Cell division control protein 42 homolog, L0028 (Mitochondria associated protein)
Authors:Chai, J., Huang, Z., Feng, Y., Wu, X.
Deposit date:2009-02-22
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Nat.Struct.Mol.Biol., 16, 2009
4J98
  • Download 4j98
  • View 4j98
Molmil generated image of 4j98
CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE GAIN-OF-FUNCTION K659Q MUTATION.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Huang, Z., Chen, H., Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.3067 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4QQC
  • Download 4qqc
  • View 4qqc
Molmil generated image of 4qqc
CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE DOMAIN IN COMPLEX WITH FIIN-2, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR CAPABLE OF OVERCOMING FGFR KINASE GATE-KEEPER MUTATIONS
Descriptor:Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-06-27
Release date:2014-10-29
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
4R6V
  • Download 4r6v
  • View 4r6v
Molmil generated image of 4r6v
CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE HARBORING THE V550L GATE-KEEPER MUTATION IN COMPLEX WITH FIIN-3, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR CAPABLE OF OVERCOMING FGFR KINASE GATE-KEEPER MUTATIONS
Descriptor:Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION
Authors:Huang, Z., Mohammadi, M.
Deposit date:2014-08-26
Release date:2014-10-29
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
3WVJ
  • Download 3wvj
  • View 3wvj
Molmil generated image of 3wvj
THE CRYSTAL STRUCTURE OF NATIVE GLYCOSIDIC HYDROLASE
Descriptor:Beta-glucanase, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Chen, C.C., Huang, J.W., Zhao, P., Ko, T.P., Huang, C.H., Chan, H.C., Huang, Z., Liu, W., Cheng, Y.S., Liu, J.R., Guo, R.T.
Deposit date:2014-05-22
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analyses and yeast production of the beta-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum.
Enzyme.Microb.Technol., 71, 2015
2I2Z
  • Download 2i2z
  • View 2i2z
Molmil generated image of 2i2z
HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND ASPIRIN
Descriptor:Serum albumin, MYRISTIC ACID, 2-HYDROXYBENZOIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2I30
  • Download 2i30
  • View 2i30
Molmil generated image of 2i30
HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND SALICYLIC ACID
Descriptor:Serum albumin, 2-HYDROXYBENZOIC ACID, MYRISTIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2NWN
  • Download 2nwn
  • View 2nwn
Molmil generated image of 2nwn
NEW PHARMACOPHORE FOR SERINE PROTEASE INHIBITION REVEALED BY CRYSTAL STRUCTURE OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR COMPLEXED WITH A CYCLIC PEPTIDYL INHIBITOR, UPAIN-1
Descriptor:Plasminogen activator, urokinase, upain-1
Authors:Zhao, G., Yuan, C., Wind, T., Andreasen, P.A., Huang, Z., Huang, M., Structural Genomics Consortium (SGC)
Deposit date:2006-11-16
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
2O8T
  • Download 2o8t
  • View 2o8t
Molmil generated image of 2o8t
CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, PENTAETHYLENE GLYCOL, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8U
  • Download 2o8u
  • View 2o8u
Molmil generated image of 2o8u
CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, BENZAMIDINE, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8W
  • Download 2o8w
  • View 2o8w
Molmil generated image of 2o8w
CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS
Descriptor:Urokinase plasminogen activator, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Zhao, G., Yuan, C., Jiang, L., Huang, Z., Huang, M.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
1MA8
  • Download 1ma8
  • View 1ma8
Molmil generated image of 1ma8
A-DNA DECAMER GCGTA(UMS)ACGC WITH INCORPORATED 2'-METHYLSELENO-URIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3'
Authors:Teplova, M., Wilds, C.J., Wawrzak, Z., Tereshko, V., Du, Q., Carrasco, N., Huang, Z., Egli, M.
Deposit date:2002-08-01
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002