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1IA1
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE (GW997)
Descriptor:DIHYDROFOLATE REDUCTASE, PHOSPHATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2001-03-22
Release date:2001-04-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem., 44, 2001
1IA2
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE, ...
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2001-03-22
Release date:2001-04-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem., 44, 2001
1IA3
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEX IN WHICH THE DIHYDRONICOTINAMIDE MOIETY OF DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) IS DISPLACED BY 5-[(4-TERT-BUTYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW995)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[4-TERT-BUTYLPHENYLSULFANYL]-2,4-QUINAZOLINEDIAMINE, ...
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2001-03-22
Release date:2001-04-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem., 44, 2001
1IA4
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEX IN WHICH THE DIHYDRONICOTINAMIDE MOIETY OF DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) IS DISPLACED BY 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE, ...
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2001-03-22
Release date:2001-04-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem., 44, 2001
1M78
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE (GW1225)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2002-07-19
Release date:2003-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex.
J.Biol.Chem., 272, 1997
1M79
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-(4-METHOXYPHENOXY)-2,4-QUINAZOLINEDIAMINE (GW1466)
Descriptor:dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-METHOXYPHENOXY)-2,4-QUINAZOLINEDIAMINE, ...
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2002-07-19
Release date:2003-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex
J.Biol.Chem., 272, 1997
1M7A
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE (GW557)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE
Authors:Whitlow, M., Howard, A.J., Kuyper, L.F.
Deposit date:2002-07-19
Release date:2003-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex.
J.Biol.Chem., 272, 1997
2RE9
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CRYSTAL STRUCTURE OF TL1A AT 2.1 A
Descriptor:TNF superfamily ligand TL1A, MAGNESIUM ION, GLYCEROL
Authors:Jin, T.C., Guo, F., Kim, S., Howard, A.J., Zhang, Y.Z.
Deposit date:2007-09-25
Release date:2007-10-09
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of TNF ligand family member TL1A at 2.1 A.
Biochem.Biophys.Res.Commun., 364, 2007
1AI9
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Whitlow, M., Howard, A.J., Stewart, D.
Deposit date:1997-05-01
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex.
J.Biol.Chem., 272, 1997
1AOE
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CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE (GW345)
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE
Authors:Whitlow, M., Howard, A.J., Stewart, D.
Deposit date:1997-07-02
Release date:1998-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex.
J.Biol.Chem., 272, 1997
1EEA
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ACETYLCHOLINESTERASE
Descriptor:PROTEIN (ACETYLCHOLINESTERASE)
Authors:Raves, M.L., Giles, K., Schrag, J.D., Schmid, M.F., Phillips Jr., G.N., Wah, C., Howard, A.J., Silman, I., Sussman, J.L.
Deposit date:1999-01-26
Release date:1999-02-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Quaternary Structure of Tetrameric Acetylcholinesterase
Structure and Function of Cholinesterases and Related Proteins, 1998
1I2K
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AMINODEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI
Descriptor:4-AMINO-4-DEOXYCHORISMATE LYASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Jensen, P.Y., Parsons, J.F., Fisher, K.E., Pachikara, A.S., Tordova, M., Howard, A.J., Eisenstein, E., Ladner, J.E.
Deposit date:2001-02-09
Release date:2003-09-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure and Mechanism of Escherichia coli Aminodeoxychorismate Lyase
To be Published
1I2L
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DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR
Descriptor:4-AMINO-4-DEOXYCHORISMATE LYASE, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE
Authors:Jensen, P.Y., Parsons, J.F., Fisher, K.E., Pachikara, A.S., Tordova, M., Howard, A.J., Eisenstein, E., Ladner, J.E.
Deposit date:2001-02-09
Release date:2003-09-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Mechanism of Escherichia coli Aminodeoxychorismate Lyase
To be Published
1I3H
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CONCANAVALIN A-DIMANNOSE STRUCTURE
Descriptor:Concanavalin-A, ALPHA-D-MANNOSE, MANGANESE (II) ION, ...
Authors:Sanders, D.A.R., Moothoo, D.N., Raftery, J., Howard, A.J., Helliwell, J.R., Naismith, J.H.
Deposit date:2001-02-15
Release date:2001-07-25
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The 1.2 A resolution structure of the Con A-dimannose complex.
J.Mol.Biol., 310, 2001
1JJV
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DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP
Descriptor:DEPHOSPHO-COA KINASE, SULFATE ION, MERCURY (II) ION, ...
Authors:Obmolova, G., Teplyakov, A., Bonander, N., Eisenstein, E., Howard, A.J., Gilliland, G.L., Structure 2 Function Project (S2F)
Deposit date:2001-07-09
Release date:2002-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.
J.Struct.Biol., 136, 2001
1JOS
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RIBOSOME BINDING FACTOR A(RBFA)
Descriptor:RIBOSOME-BINDING FACTOR A
Authors:Bonander, N., Tordova, M., Howard, A.J., Eisenstein, E., Gilliland, G.L., Structure 2 Function Project (S2F)
Deposit date:2001-07-30
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The 1.7-A Crystal Structure of HI1288 - Ribosome Binding Factor A (rbfA), a Cold Response Protein
To be Published
1JOV
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CRYSTAL STRUCTURE ANALYSIS OF HI1317
Descriptor:HI1317, SULFATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Bonander, N., Tordova, M., Howard, A.J., Eisenstein, E., Gilliland, G., Structure 2 Function Project (S2F)
Deposit date:2001-07-31
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Crystal 1.57-A Crystal Structure of HI1317
TO BE PUBLISHED
1K0E
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THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM FORMATE GROWN CRYSTALS
Descriptor:p-aminobenzoate synthase component I, TRYPTOPHAN, FORMIC ACID
Authors:Parsons, J.F., Jensen, P.Y., Pachikara, A.S., Howard, A.J., Eisenstein, E., Ladner, J.E.
Deposit date:2001-09-19
Release date:2002-02-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes.
Biochemistry, 41, 2002
1K0G
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THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM PHOSPHATE GROWN CRYSTALS
Descriptor:p-aminobenzoate synthase component I, PHOSPHATE ION, TRYPTOPHAN
Authors:Parsons, J.F., Jensen, P.Y., Pachikara, A.S., Howard, A.J., Eisenstein, E., Ladner, J.E.
Deposit date:2001-09-19
Release date:2002-02-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes.
Biochemistry, 41, 2002
1LQA
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TAS PROTEIN FROM ESCHERICHIA COLI IN COMPLEX WITH NADPH
Descriptor:Tas protein, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Obmolova, G., Teplyakov, A., Khil, P.P., Howard, A.J., Camerini-Otero, R.D., Gilliland, G.L., Structure 2 Function Project (S2F)
Deposit date:2002-05-09
Release date:2003-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.604 Å)
Cite:Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase
PROTEINS: STRUCT.,FUNCT.,GENET., 53, 2003
1NIJ
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YJIA PROTEIN
Descriptor:Hypothetical protein yjiA
Authors:Khil, P.P., Obmolova, G., Teplyakov, A., Howard, A.J., Gilliland, G.L., Camerini-Otero, R.D., Structure 2 Function Project (S2F)
Deposit date:2002-12-24
Release date:2003-06-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function.
Proteins, 54, 2004
1PGX
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THE 1.66 ANGSTROMS X-RAY STRUCTURE OF THE B2 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G AND COMPARISON TO THE NMR STRUCTURE OF THE B1 DOMAIN
Descriptor:PROTEIN G
Authors:Whitlow, M., Achari, A., Howard, A.J.
Deposit date:1992-04-03
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:1.67-A X-ray structure of the B2 immunoglobulin-binding domain of streptococcal protein G and comparison to the NMR structure of the B1 domain.
Biochemistry, 31, 1992
1Q8H
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CRYSTAL STRUCTURE OF PORCINE OSTEOCALCIN
Descriptor:Osteocalcin, CALCIUM ION
Authors:Hoang, Q.Q., Sicheri, F., Howard, A.J., Yang, D.S.
Deposit date:2003-08-21
Release date:2003-11-11
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bone recognition mechanism of porcine osteocalcin from crystal structure.
Nature, 425, 2003
1XIS
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A METAL-MEDIATED HYDRIDE SHIFT MECHANISM FOR XYLOSE ISOMERASE BASED ON THE 1.6 ANGSTROMS STREPTOMYCES RUBIGINOSUS STRUCTURES WITH XYLITOL AND D-XYLOSE
Descriptor:XYLOSE ISOMERASE, MANGANESE (II) ION
Authors:Whitlow, M., Howard, A.J.
Deposit date:1991-03-25
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 A Streptomyces rubiginosus structures with xylitol and D-xylose.
Proteins, 9, 1991
2F6L
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X-RAY STRUCTURE OF CHORISMATE MUTASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Chorismate mutase
Authors:Kim, S.K., Howard, A.J., Gilliland, G.L., Reddy, P.T., Ladner, J.E.
Deposit date:2005-11-29
Release date:2005-12-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biochemical and structural characterization of the secreted chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv: an *AroQ enzyme not regulated by the aromatic amino acids.
J.Bacteriol., 188, 2006