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6NAQ
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BU of 6naq by Molmil
Crystal structure of Neisseria meningitidis ClpP protease in Apo form
Descriptor: ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION
Authors:Houry, W.A, Mabanglo, M.F, Pai, E.F, Eger, B.T, Bryson, S.
Deposit date:2018-12-06
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.022 Å)
Cite:ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.
Commun Biol, 2, 2019
6W9T
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BU of 6w9t by Molmil
Crystal structure of Neisseria meningitidis ClpP protease complex with small molecule activator ACP1-06
Descriptor: ATP-dependent Clp protease proteolytic subunit, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide, POTASSIUM ION
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2020-03-23
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.
Acs Infect Dis., 6, 2020
7UVM
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BU of 7uvm by Molmil
Crystal structure of human ClpP protease in complex with TR-27
Descriptor: (10R)-4-[(4-chlorophenyl)methyl]-7-[(3-ethynylphenyl)methyl]-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2022-05-02
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31, 2023
7UVU
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BU of 7uvu by Molmil
Crystal structure of human ClpP protease in complex with TR-107
Descriptor: 3-({3-[(4-chlorophenyl)methyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2022-05-02
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31, 2023
7UVR
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BU of 7uvr by Molmil
Crystal structure of human ClpP protease in complex with TR-65
Descriptor: 3-{[(10R)-4-[(4-chlorophenyl)methyl]-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl]methyl}benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2022-05-02
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31, 2023
7UW0
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BU of 7uw0 by Molmil
Crystal structure of human ClpP protease in complex with TR-133
Descriptor: 3-({3-[(4-bromophenyl)methyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2022-05-02
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31, 2023
7UVN
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BU of 7uvn by Molmil
Crystal structure of human ClpP protease in complex with TR-57
Descriptor: 3-({3-[(4-chlorophenyl)methyl]-1-methyl-2,4-dioxo-1,3,4,5,7,8-hexahydropyrido[4,3-d]pyrimidin-6(2H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2022-05-02
Release date:2023-01-11
Last modified:2023-03-01
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31, 2023
2L6J
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BU of 2l6j by Molmil
Tah1 complexed by MEEVD
Descriptor: C-terminus Hsp90 chaperone peptide MEEVD, TPR repeat-containing protein associated with Hsp90
Authors:Jimenez, B, Ugwu, F, Zhao, R, Orti, L, Houry, W.A, Pineda-Lucena, A.
Deposit date:2010-11-22
Release date:2011-12-28
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90.
J.Biol.Chem., 287, 2012
1Y7O
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BU of 1y7o by Molmil
The structure of Streptococcus pneumoniae A153P ClpP
Descriptor: ATP-dependent Clp protease proteolytic subunit, CALCIUM ION
Authors:Kimber, M.S, Gribun, A, Ching, R, Sprangers, R, Fiebig, K.M, Houry, W.A.
Deposit date:2004-12-09
Release date:2005-02-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation.
J.Biol.Chem., 280, 2005
6BBA
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BU of 6bba by Molmil
Crystal structure of human mitochondrial ClpP complex with acyldepsipeptide ADEP-28
Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, Acyldepsipeptide ADEP-28
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2017-10-17
Release date:2018-07-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.
Cell Chem Biol, 25, 2018
5FL2
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BU of 5fl2 by Molmil
Revisited cryo-EM structure of Inducible lysine decarboxylase complexed with LARA domain of RavA ATPase
Descriptor: ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE
Authors:Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I.
Deposit date:2015-10-21
Release date:2016-09-21
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava.
Sci.Rep., 6, 2016
7UGC
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BU of 7ugc by Molmil
Structure of the N-terminal domain of ViaA
Descriptor: Protein ViaA
Authors:Lemak, A, Reichheld, S, Bhandari, V, Houliston, S, Arrowsmith, C.H, Sharpe, S, Houry, W.A.
Deposit date:2022-03-24
Release date:2023-03-29
Method:SOLUTION NMR
Cite:Structure of the N-terminal domain of ViaA
To Be Published
3HLN
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BU of 3hln by Molmil
Crystal structure of ClpP A153C mutant with inter-heptamer disulfide bonds
Descriptor: ATP-dependent Clp protease proteolytic subunit, CALCIUM ION
Authors:Kimber, M.S, Yu, A.Y.H, Borg, M, Chan, H.S, Houry, W.A.
Deposit date:2009-05-27
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations.
Structure, 18, 2010
3N75
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BU of 3n75 by Molmil
X-ray Crystal Structure of the Escherichia coli Inducible Lysine Decarboxylase LdcI
Descriptor: GLYCEROL, GUANOSINE-5',3'-TETRAPHOSPHATE, HEXAETHYLENE GLYCOL, ...
Authors:Kanjee, U, Alexopoulos, E, Pai, E.F, Houry, W.A.
Deposit date:2010-05-26
Release date:2011-02-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
Embo J., 30, 2011
4UPB
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BU of 4upb by Molmil
Electron cryo-microscopy of the complex formed between the hexameric ATPase RavA and the decameric inducible decarboxylase LdcI
Descriptor: ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE
Authors:Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I.
Deposit date:2014-06-15
Release date:2014-08-20
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins.
Elife, 3, 2014
4UPF
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BU of 4upf by Molmil
Assembly principles of the unique cage formed by the ATPase RavA hexamer and the lysine decarboxylase LdcI decamer
Descriptor: ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE
Authors:Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I.
Deposit date:2014-06-16
Release date:2014-08-20
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins.
Elife, 3, 2014
1OVX
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BU of 1ovx by Molmil
NMR structure of the E. coli ClpX chaperone zinc binding domain dimer
Descriptor: ATP-dependent Clp protease ATP-binding subunit clpX, ZINC ION
Authors:Donaldson, L.W, Kwan, J, Wojtyra, U, Houry, W.A.
Deposit date:2003-03-27
Release date:2003-12-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the dimeric zinc binding domain of the chaperone ClpX.
J.Biol.Chem., 278, 2003
5DKP
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BU of 5dkp by Molmil
Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.
Descriptor: ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION, SODIUM ION, ...
Authors:Goodreid, J.D, Janetzko, J, Santa Maria Jr, J.P, Wong, K, Leung, E, Eger, B.T, Bryson, S, Pai, E.F, Gray-Owen, S.D, Walker, S, Houry, W.A, Batey, R.A.
Deposit date:2015-09-03
Release date:2016-01-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.
J.Med.Chem., 59, 2016
5FKX
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BU of 5fkx by Molmil
Structure of E.coli inducible lysine decarboxylase at active pH
Descriptor: LYSINE DECARBOXYLASE, INDUCIBLE
Authors:Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I.
Deposit date:2015-10-20
Release date:2016-09-21
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava.
Sci.Rep., 6, 2016
5FKZ
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BU of 5fkz by Molmil
Structure of E.coli Constitutive lysine decarboxylase
Descriptor: LYSINE DECARBOXYLASE, CONSTITUTIVE
Authors:Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I.
Deposit date:2015-10-20
Release date:2016-09-21
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava.
Sci.Rep., 6, 2016
4GM2
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BU of 4gm2 by Molmil
The crystal structure of a peptidase from plasmodium falciparum
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:El Bakkouri, M, Jung, P, Wernimont, A.K, Calmettes, C, Hui, R, Houry, W.A, Structural Genomics Consortium (SGC)
Deposit date:2012-08-15
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum.
J.Biol.Chem., 288, 2013
4HNK
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BU of 4hnk by Molmil
Crystal structure of an Enzyme
Descriptor: ATP-dependent Clp protease proteolytic subunit, GLYCEROL
Authors:El Bakkouri, M, Calmettes, C, Wernimont, A.K, Houry, W.A, Hui, R, Structural Genomics Consortium (SGC)
Deposit date:2012-10-19
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum.
J.Biol.Chem., 288, 2013
6NB1
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BU of 6nb1 by Molmil
Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06
Descriptor: ATP-dependent Clp protease proteolytic subunit, GLYCEROL, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide
Authors:Mabanglo, M.F, Houry, W.A, Eger, B.T, Bryson, S, Pai, E.F.
Deposit date:2018-12-06
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.
Commun Biol, 2, 2019
6NAY
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BU of 6nay by Molmil
Crystal structure of Neisseria meningitidis ClpP protease E31A+E58A activated double mutant
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2018-12-06
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.
Commun Biol, 2, 2019
6NAH
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BU of 6nah by Molmil
Crystal structure of Neisseria meningitidis ClpP protease in complex with Acyldepsipeptide-14 (ADEP-14)
Descriptor: ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide-14, OCTANOIC ACID (CAPRYLIC ACID)
Authors:Mabanglo, M.F, Houry, W.A.
Deposit date:2018-12-05
Release date:2019-11-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.
Commun Biol, 2, 2019

 

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