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1F2T
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BU of 1f2t by Molmil
Crystal Structure of ATP-Free RAD50 ABC-ATPase
Descriptor: RAD50 ABC-ATPASE
Authors:Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L.
Deposit date:2000-05-29
Release date:2000-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell(Cambridge,Mass.), 101, 2000
1F2U
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BU of 1f2u by Molmil
Crystal Structure of RAD50 ABC-ATPase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAD50 ABC-ATPASE
Authors:Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L.
Deposit date:2000-05-29
Release date:2000-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell(Cambridge,Mass.), 101, 2000
1FXY
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BU of 1fxy by Molmil
COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE
Descriptor: COAGULATION FACTOR XA-TRYPSIN CHIMERA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:Hopfner, K.P, Kopetzki, E, Kresse, G.-B, Huber, R, Bode, W, Engh, R.A.
Deposit date:1998-04-22
Release date:1998-06-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:New enzyme lineages by subdomain shuffling.
Proc.Natl.Acad.Sci.USA, 95, 1998
1L8D
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BU of 1l8d by Molmil
Rad50 coiled-coil Zn hook
Descriptor: CITRIC ACID, DNA double-strand break repair rad50 ATPase, MERCURY (II) ION, ...
Authors:Hopfner, K.P, Tainer, J.A.
Deposit date:2002-03-20
Release date:2002-08-28
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Nature, 418, 2002
1S8E
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BU of 1s8e by Molmil
Crystal structure of Mre11-3
Descriptor: MANGANESE (II) ION, exonuclease putative
Authors:Hopfner, K.P.
Deposit date:2004-02-02
Release date:2004-08-10
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional analysis of Mre11-3
Nucleic Acids Res., 32, 2004
2BA1
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BU of 2ba1 by Molmil
Archaeal exosome core
Descriptor: Archaeal exosome RNA binding protein CSL4, Archaeal exosome complex exonuclease RRP41, Archaeal exosome complex exonuclease RRP42, ...
Authors:Hopfner, K.P, Buttner, K, Wenig, K.
Deposit date:2005-10-13
Release date:2005-11-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural framework for the mechanism of archaeal exosomes in RNA processing.
Mol.Cell, 20, 2005
3RA7
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BU of 3ra7 by Molmil
Bispecific digoxigenin binding antibodies for targeted payload delivery
Descriptor: DIGOXIGENIN, Fab fragment, heavy chain, ...
Authors:Hopfner, K.P, Lammens, A.
Deposit date:2011-03-27
Release date:2011-07-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Bispecific digoxigenin-binding antibodies for targeted payload delivery
Proc.Natl.Acad.Sci.USA, 108, 2011
2W4R
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BU of 2w4r by Molmil
Crystal structure of the regulatory domain of human LGP2
Descriptor: MERCURY (II) ION, PROBABLE ATP-DEPENDENT RNA HELICASE DHX58, SULFATE ION
Authors:Pippig, D.A, Hellmuth, J.C, Cui, S, Kirchhofer, A, Lammens, K, Lammens, A, Schmidt, A, Rothenfusser, S, Hopfner, K.P.
Deposit date:2008-12-01
Release date:2009-02-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Regulatory Domain of the Rig-I Family ATPase Lgp2 Senses Double-Stranded RNA.
Nucleic Acids Res., 37, 2009
2XGP
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BU of 2xgp by Molmil
Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA
Descriptor: 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ...
Authors:Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T.
Deposit date:2010-06-07
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Proc.Natl.Acad.Sci.USA, 107, 2010
8AV6
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BU of 8av6 by Molmil
CryoEM structure of INO80 core nucleosome complex in closed grappler conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DASH complex subunit DAD4, ...
Authors:Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P.
Deposit date:2022-08-26
Release date:2022-12-14
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (4.68 Å)
Cite:Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Adv, 8, 2022
8ATF
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BU of 8atf by Molmil
Nucleosome-bound Ino80 ATPase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (226-MER), DNA (227-MER), ...
Authors:Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P.
Deposit date:2022-08-23
Release date:2022-12-14
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Adv, 8, 2022
8BAH
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BU of 8bah by Molmil
Human Mre11-Nbs1 complex
Descriptor: Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin
Authors:Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P.
Deposit date:2022-10-11
Release date:2023-01-11
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
7YZP
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BU of 7yzp by Molmil
Hairpin-bound state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and a DNA hairpin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA hairpin (59-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
7YZO
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BU of 7yzo by Molmil
Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
7Z03
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BU of 7z03 by Molmil
Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
6GK2
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BU of 6gk2 by Molmil
Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex
Descriptor: B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Schlauderer, F, Desfosses, A, Gutsche, I, Hopfner, K.P, Lammens, K.
Deposit date:2018-05-18
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Molecular architecture and regulation of BCL10-MALT1 filaments.
Nat Commun, 9, 2018
4LEO
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BU of 4leo by Molmil
Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RG7116 Fab heavy chain, ...
Authors:Schiller, C.B, Hopfner, K.P.
Deposit date:2013-06-26
Release date:2013-07-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation.
Cancer Res., 73, 2013
6S85
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BU of 6s85 by Molmil
Cutting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), DNA (32-MER), ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-08
Release date:2019-09-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
6S6V
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BU of 6s6v by Molmil
Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-03
Release date:2019-09-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
4ON9
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BU of 4on9 by Molmil
DECH box helicase domain
Descriptor: CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58, SULFATE ION
Authors:Deimling, T, Witte, G, Hopfner, K.P.
Deposit date:2014-01-28
Release date:2014-07-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal and solution structure of the human RIG-I SF2 domain
Acta Crystallogr.,Sect.F, 70, 2014
6SKY
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BU of 6sky by Molmil
FAT and kinase domain of CtTel1
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SL0
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BU of 6sl0 by Molmil
Complete CtTel1 dimer with C2 symmetry
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SL1
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BU of 6sl1 by Molmil
Structure of the open conformation of CtTel1
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2020-05-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SKZ
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BU of 6skz by Molmil
Structure of the closed conformation of CtTel1
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
1YQT
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BU of 1yqt by Molmil
RNase-L Inhibitor
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RNase l inhibitor
Authors:Karcher, A, Buttner, K, Martens, B, Jansen, R.P, Hopfner, K.P.
Deposit date:2005-02-02
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly.
Structure, 13, 2005

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