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3WPW
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STRUCTURE OF POMBC5, A PERIPLASMIC FRAGMENT OF POMB FROM VIBRIO
Descriptor:PomB, ACETATE ION
Authors:Takao, M., Sakuma, M., Zhu, S., Homma, M., Kojima, S., Imada, K.
Deposit date:2014-01-17
Release date:2014-09-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational change in the periplasmic region of the flagellar stator coupled with the assembly around the rotor
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
3WPX
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STRUCTURE OF POMBC4, A PERIPLASMIC FRAGMENT OF POMB FROM VIBRIO ALGINOLYTICUS
Descriptor:PomB
Authors:Takao, M., Sakuma, M., Zhu, S., Homma, M., Kojima, S., Imada, K.
Deposit date:2014-01-17
Release date:2014-09-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational change in the periplasmic region of the flagellar stator coupled with the assembly around the rotor
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
5Y3Z
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STRUCTURE OF THE PERIPLASMIC DOMAIN OF THE MOTB L119P MUTANT FROM SALMONELLA (CRYSTAL FORM 1)
Descriptor:Motility protein B, ARGININE, IMIDAZOLE, ...
Authors:Takao, M., Kojima, S., Sakuma, M., Homma, M., Imada, K.
Deposit date:2017-07-31
Release date:2018-04-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.
Structure, 26, 2018
5Y40
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STRUCTURE OF THE PERIPLASMIC DOMAIN OF THE MOTB L119P MUTANT FROM SALMONELLA (CRYSTAL FORM 2)
Descriptor:Motility protein B
Authors:Takao, M., Kojima, S., Sakuma, M., Homma, M., Imada, K.
Deposit date:2017-07-31
Release date:2018-04-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Helix Rearrangement in the Periplasmic Domain of the Flagellar Stator B Subunit Activates Peptidoglycan Binding and Ion Influx.
Structure, 26, 2018
6AHP
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STRUCTURE OF THE 58-167 FRAGMENT OF FLIL
Descriptor:Flagellar protein FliL
Authors:Takekawa, N., Isumi, M., Sakuma, M., Kojima, S., Homma, M., Imada, K.
Deposit date:2018-08-20
Release date:2019-03-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function.
MBio, 10, 2019
6AHQ
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STRUCTURE OF THE 40-167 FRAGMENT OF FLIL
Descriptor:Flagellar protein FliL
Authors:Takekawa, N., Isumi, M., Sakuma, M., Kojima, S., Homma, M., Imada, K.
Deposit date:2018-08-20
Release date:2019-03-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.398 Å)
Cite:Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function.
MBio, 10, 2019
2D4U
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CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE BACTERIAL SERINE CHEMORECEPTOR TSR
Descriptor:Methyl-accepting chemotaxis protein I
Authors:Imada, K., Tajima, H., Namba, K., Sakuma, M., Homma, M., Kawagishi, I.
Deposit date:2005-10-24
Release date:2006-11-14
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ligand specificity determined by differentially arranged common ligand-binding residues in the bacterial amino acid chemoreceptors Tsr and Tar.
J.Biol.Chem., 2011
2ZF8
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CRYSTAL STRUCTURE OF MOTY
Descriptor:Component of sodium-driven polar flagellar motor
Authors:Imada, K., Kojima, S., Namba, K., Homma, M.
Deposit date:2007-12-25
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Insights into the stator assembly of the Vibrio flagellar motor from the crystal structure of MotY
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZOV
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STRUCTURE OF THE PERIPLASMIC DOMAIN OF MOTB FROM SALMONELLA (CRYSTAL FORM I)
Descriptor:Chemotaxis protein motB
Authors:Imada, K., Kojima, S., Namba, K., Homma, M.
Deposit date:2008-06-09
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB
Mol.Microbiol., 73, 2009
2ZVY
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STRUCTURE OF THE PERIPLASMIC DOMAIN OF MOTB FROM SALMONELLA (CRYSTAL FORM II)
Descriptor:Chemotaxis protein motB
Authors:Kojima, S., Homma, M., Namba, K., Imada, K.
Deposit date:2008-11-26
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB
Mol.Microbiol., 73, 2009
3W0D
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STRUCTURE OF ELASTASE INHIBITOR AFUEI (CYRSTAL FORM I)
Descriptor:Elastase inhibitor AFUEI
Authors:Imada, K., Sakuma, M., Okumura, Y., Ogawa, K., Nikai, T., Homma, M.
Deposit date:2012-10-29
Release date:2013-05-15
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structure Analysis and Characterization of AFUEI, an Elastase Inhibitor from Aspergillus fumigatus
J.Biol.Chem., 288, 2013
3W0E
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STRUCTURE OF ELASTASE INHIBITOR AFUEI (CRYSTAL FORM II)
Descriptor:Elastase inhibitor AFUEI
Authors:Imada, K., Sakuma, M., Okumura, Y., Ogawa, K., Nikai, T., Homma, M.
Deposit date:2012-10-29
Release date:2013-05-15
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray Structure Analysis and Characterization of AFUEI, an Elastase Inhibitor from Aspergillus fumigatus
J.Biol.Chem., 288, 2013
3W1E
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STRUCTURE OF FLGT, A FLAGELLAR BASAL BODY COMPONENT PROTEIN
Descriptor:Flagella basal-body protein
Authors:Terashima, H., Sakuma, M., Homma, M., Imada, K.
Deposit date:2012-11-14
Release date:2013-04-03
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT
Proc.Natl.Acad.Sci.USA, 110, 2013
3ATP
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STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE BACTERIAL SERINE CHEMORECEPTOR TSR WITH LIGAND
Descriptor:Methyl-accepting chemotaxis protein I, SERINE
Authors:Tajima, H., Sakuma, M., Homma, K., Kawagishi, I., Imada, K.
Deposit date:2011-01-07
Release date:2011-10-19
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar.
J.Biol.Chem., 286, 2011
2ZVZ
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STRUCTURE OF THE PERIPLASMIC DOMAIN OF MOTB FROM SALMONELLA (CRYSTAL FORM III)
Descriptor:Chemotaxis protein motB
Authors:Imada, K., Kojima, S., Namba, K., Homma, S.
Deposit date:2008-11-26
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB
Mol.Microbiol., 73, 2009
3WIX
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 4
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIY
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIZ
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 10
Descriptor:Bcl-2-like protein 1, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, PHOSPHATE ION
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
5AVE
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THE LIGAND BINDING DOMAIN OF MLP37 WITH SERINE
Descriptor:Methyl-accepting chemotaxis (MCP) signaling domain protein, SERINE
Authors:Takahashi, Y., Sumita, K., Uchida, Y., Nishiyama, S., Kawagishi, I., Imada, K.
Deposit date:2015-06-15
Release date:2016-03-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants
Sci Rep, 6, 2016
5AVF
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THE LIGAND BINDING DOMAIN OF MLP37 WITH TAURINE
Descriptor:Methyl-accepting chemotaxis (MCP) signaling domain protein, 2-AMINOETHANESULFONIC ACID
Authors:Takahashi, Y., Sumita, K., Uchida, Y., Nishiyama, S., Kawagishi, I., Imada, K.
Deposit date:2015-06-15
Release date:2016-06-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants
Sci Rep, 6, 2016
5U7Q
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IDENTIFICATION OF A NEW CLASS OF POTENT CDC7 INHIBITORS DESIGNED BY PUTATIVE PHARMACOPHORE MODEL: SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,3-DIHYDROTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONES
Descriptor:Rho-associated protein kinase 2
Authors:Hoffman, I.D.
Deposit date:2016-12-12
Release date:2017-03-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg. Med. Chem., 25, 2017
5U7R
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IDENTIFICATION OF A NEW CLASS OF POTENT CDC7 INHIBITORS DESIGNED BY PUTATIVE PHARMACOPHORE MODEL: SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,3-DIHYDROTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONES
Descriptor:Rho-associated protein kinase 2, (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one
Authors:Hoffman, I.D., Skene, R.J.
Deposit date:2016-12-12
Release date:2017-03-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg. Med. Chem., 25, 2017