Author results

2W6R
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CRYSTAL STRUCTURE OF AN ARTIFICIAL (BA)8-BARREL PROTEIN DESIGNED FROM IDENTICAL HALF BARRELS
Descriptor:IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF
Authors:Hocker, B., Lochner, A., Seitz, T., Claren, J., Sterner, R.
Deposit date:2008-12-18
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-Resolution Crystal Structure of an Artificial (Betaalpha)(8)-Barrel Protein Designed from Identical Half-Barrels.
Biochemistry, 48, 2009
4QWV
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A PBP-LIKE PROTEIN BUILT FROM FRAGMENTS OF DIFFERENT FOLDS
Descriptor:High-affinity leucine-specific transport system periplasmic binding protein, Chemotaxis protein CheY
Authors:Hocker, B., Farias-Rico, J.A., Goetz, S., Toledo-Patino, S.
Deposit date:2014-07-17
Release date:2016-01-27
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:A PBP-like protein built from fragments of different folds
To be Published
4Q37
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CRYSTAL STRUCTURE OF THE HYPOTHETICAL PROTEIN TM0182 THERMOTOGA MARITIMA, N-TERMINAL DOMAIN.
Descriptor:Radical SAM protein, PLATINUM (II) ION
Authors:Hocker, B., Farias-Rico, J.A.
Deposit date:2014-04-11
Release date:2014-07-16
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Evolutionary relationship of two ancient protein superfolds.
Nat.Chem.Biol., 10, 2014
2WRZ
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CRYSTAL STRUCTURE OF AN ARABINOSE BINDING PROTEIN WITH DESIGNED SEROTONIN BINDING SITE IN OPEN, LIGAND-FREE STATE
Descriptor:L-ARABINOSE-BINDING PERIPLASMIC PROTEIN
Authors:Schreier, B., Stumpp, C., Wiesner, S., Hocker, B.
Deposit date:2009-09-03
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Computational Design of Ligand Binding is not a Solved Problem
Proc.Natl.Acad.Sci.USA, 106, 2009
2GHA
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THERMOTOGA MARITIMA MALTOTRIOSE BINDING PROTEIN BOUND WITH MALTOTRIOSE
Descriptor:maltose ABC transporter, periplasmic maltose-binding protein, MALTOTRIOSE
Authors:Cuneo, M.J., Changela, A., Hocker, B., Beese, L.S., Hellinga, H.W.
Deposit date:2006-03-27
Release date:2007-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:T. maritima maltotriose binding protein
To be Published
2GHB
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THERMOTOGA MARITIMA MALTOTRIOSE BINDING PROTEIN, LIGAND FREE FORM
Descriptor:maltose ABC transporter, periplasmic maltose-binding protein
Authors:Cuneo, M.J., Changela, A., Hocker, B., Beese, L.S., Hellinga, H.W.
Deposit date:2006-03-27
Release date:2007-02-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:T. maritima maltotriose binding protein open form
To be Published
2LLE
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COMPUTATIONAL DESIGN OF AN EIGHT-STRANDED (BETA/ALPHA)-BARREL FROM FRAGMENTS OF DIFFERENT FOLDS
Descriptor:Chemotaxis protein CheY, Imidazole glycerol phosphate synthase subunit HisF chimera
Authors:Coles, M., Truffault, V., Eisenbeis, S., Proffitt, W., Meiler, J., Hocker, B.
Deposit date:2011-11-07
Release date:2012-03-21
Method:SOLUTION NMR
Cite:Potential of fragment recombination for rational design of proteins.
J.Am.Chem.Soc., 134, 2012
2W79
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ESTABLISHING WILD-TYPE LEVELS OF CATALYTIC ACTIVITY ON NATURAL AND ARTIFICIAL (BA)8-BARREL PROTEIN SCAFFOLDS
Descriptor:1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION
Authors:Claren, J., Malisi, C., Hocker, B., Sterner, R.
Deposit date:2008-12-21
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Establishing Wild-Type Levels of Catalytic Activity on Natural and Artificial (Beta Alpha)8- Barrel Protein Scaffolds.
Proc.Natl.Acad.Sci.USA, 106, 2009
3CWO
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A BETA/ALPHA-BARREL BUILT BY THE COMBINATION OF FRAGMENTS FROM DIFFERENT FOLDS
Descriptor:beta/alpha-barrel protein based on 1THF and 1TMY, SULFATE ION
Authors:Bharat, T.A.M., Eisenbeis, S., Zeth, K., Hocker, B.
Deposit date:2008-04-22
Release date:2008-07-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A beta alpha-barrel built by the combination of fragments from different folds.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4J5N
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CRYSTAL STRUCTURE OF A DEINOCOCCUS RADIODURANS PTE-LIKE LACTONASE (DRPLL) MUTANT Y28L/D71N/E101G/E179D/V235L/L270M
Descriptor:Phosphotriesterase, putative, COBALT (II) ION
Authors:Meier, M.M., Rajendran, C., Malisi, C., Fox, N.G., Xu, C., Schlee, S., Barondeau, D.P., Hocker, B., Sterner, R., Raushel, F.M.
Deposit date:2013-02-08
Release date:2013-07-24
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
J.Am.Chem.Soc., 135, 2013
4JDF
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CRYSTAL STRUCTURE OF A POTF MUTANT COMPLEXED WITH SPERMIDINE
Descriptor:Putrescine-binding periplasmic protein, SPERMIDINE
Authors:Scheib, U., Shanmugaratnam, S., Farias-Rico, J.A., Hocker, B.
Deposit date:2013-02-25
Release date:2013-07-10
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Change in protein-ligand specificity through binding pocket grafting.
J.Struct.Biol., 185, 2014
5BVL
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED TIM-BARREL
Descriptor:designed TIM barrel sTIM11
Authors:Feldmeier, K., Hocker, B.
Deposit date:2015-06-05
Release date:2015-11-18
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy.
Nat.Chem.Biol., 12, 2016
5OWF
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STRUCTURE OF A LAO-BINDING PROTEIN MUTANT WITH GLUTAMINE
Descriptor:Lysine/arginine/ornithine-binding periplasmic protein, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Shanmugaratnam, S., Banda-Vazquez, J., Sosa-Peinado, A., Hocker, B.
Deposit date:2017-08-31
Release date:2018-03-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Redesign of LAOBP to bind novel l-amino acid ligands.
Protein Sci., 27, 2018
6EJW
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI WILDTYPE WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-23
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6EJZ
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID, 1,2-ETHANEDIOL, ...
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-24
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6EKP
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT T44L T81M S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID, 3,6,9,12,15-PENTAOXAHEPTADECANE
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-26
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6ELB
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT M42F T44L T81M N87G S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-28
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.437 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6ELF
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT M42F T44L T81I S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-28
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.832 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6ELG
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT M42F T44L T81I S88Y WITH INDOLE-3-ACETONITRILE
Descriptor:Trp operon repressor, 1H-indol-3-ylacetonitrile
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-09-28
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6ENI
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT T44L S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID, 1,2-ETHANEDIOL
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-10-04
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6ENN
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI VARIANT T44L T81M N87G S88Y WITH INDOLE-3-ACETIC ACID AS LIGAND
Descriptor:Trp operon repressor, 1H-INDOL-3-YLACETIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Herud-Sikimic, O., Juergens, G., Hocker, B.
Deposit date:2017-10-05
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Auxin Sensor based on the Tryptophan Repressor TrpR
To Be Published
6F7F
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI WITH 3-INDOLEPROPIONIC ACID
Descriptor:Trp operon repressor, INDOLYLPROPIONIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Hocker, B.
Deposit date:2017-12-08
Release date:2019-03-27
Method:X-RAY DIFFRACTION (2.128 Å)
Cite:Tryptophan Repressor TrpR: A study of ligand binding specificity
To Be Published
6F7G
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI WITH 5-METHYLTRYPTAMINE
Descriptor:Trp operon repressor, 2-(5-methyl-1~{H}-indol-3-yl)ethanamine
Authors:Stiel, A.C., Shanmugaratnam, S., Hocker, B.
Deposit date:2017-12-08
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.656 Å)
Cite:Tryptophan Repressor TrpR: A ligand specificity study
To Be Published
6F9K
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI WITH 5-METHYL-L-TRYPTOPHAN AS LIGAND
Descriptor:Trp operon repressor, 5-methyl-L-tryptophan, SULFATE ION
Authors:Stiel, A.C., Shanmugaratnam, S., Hocker, B.
Deposit date:2017-12-14
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Tryptophan Repressor TrpR from E.coli: A ligand binding study
To Be Published
6FAL
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TRYPTOPHAN REPRESSOR TRPR FROM E.COLI WITH 3-INDOLEPROPIONIC ACID AS LIGAND
Descriptor:Trp operon repressor, INDOLYLPROPIONIC ACID
Authors:Stiel, A.C., Shanmugaratnam, S., Hocker, B.
Deposit date:2017-12-15
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Tryptophan Repressor TrpR from E.coli: A ligand binding study
To Be Published
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