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5MRU
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BU of 5mru by Molmil
TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
Descriptor: 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, Tetracycline Repressor, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2016-12-26
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
To Be Published
6YR1
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BU of 6yr1 by Molmil
TetR(D) soaked with Tigecycline I4(1)22
Descriptor: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ...
Authors:Hinrichs, W, Stary, K.
Deposit date:2020-04-18
Release date:2021-04-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:TetR(D) soaked with Tigecycline
to be published
6YR2
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BU of 6yr2 by Molmil
TetR(D) soaked with Tigecycline P4(1)2(1)2
Descriptor: CHLORIDE ION, MAGNESIUM ION, SULFATE ION, ...
Authors:Hinrichs, W, Stary, K.
Deposit date:2020-04-19
Release date:2021-04-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:TetR(D) soaked with Tigecycline
to be published
2TRT
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BU of 2trt by Molmil
TETRACYCLINE REPRESSOR CLASS D
Descriptor: MAGNESIUM ION, TETRACYCLINE, TETRACYCLINE REPRESSOR CLASS D
Authors:Hinrichs, W, Kisker, C, Saenger, W.
Deposit date:1994-03-04
Release date:1996-06-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
6FPL
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BU of 6fpl by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
2TCT
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BU of 2tct by Molmil
THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
Descriptor: 7-CHLOROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
Authors:Hinrichs, W, Kisker, C, Saenger, W.
Deposit date:1995-03-02
Release date:1996-04-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
J.Mol.Biol., 247, 1995
6FPM
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BU of 6fpm by Molmil
TetR(D) T103A mutant in complex with tetracycline and magnesium
Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FTS
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BU of 6fts by Molmil
TETR(D) N82A MUTANT IN COMPLEX WITH PEG4
Descriptor: CHLORIDE ION, TETRAETHYLENE GLYCOL, Tetracycline repressor protein class D
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-23
Release date:2019-02-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJX
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BU of 6qjx by Molmil
TetR(D) T103A mutant in complex with minocycline and magnesium
Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-01-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJW
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BU of 6qjw by Molmil
TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium
Descriptor: 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-01-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RBL
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BU of 6rbl by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RBM
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BU of 6rbm by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM
Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-11
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RCR
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BU of 6rcr by Molmil
TETR(D) H100A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-11
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RGX
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BU of 6rgx by Molmil
TETR(D) N82A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-17
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
2XB5
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BU of 2xb5 by Molmil
Tet repressor (class D) in complex with 7-Iodotetracycline
Descriptor: 7-IODOTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Kisker, C, Saenger, W, Hinrichs, W.
Deposit date:2010-04-05
Release date:2010-10-06
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
8B7U
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BU of 8b7u by Molmil
Bacterial chalcone isomerase H33A with taxifolin
Descriptor: (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, CHLORIDE ION, Chalcone isomerase, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2022-10-03
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
8B7R
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BU of 8b7r by Molmil
Bacterial chalcone isomerase with taxifolin chalcone
Descriptor: (Z)-3-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-1-[2,4,6-tris(oxidanyl)phenyl]prop-2-en-1-one, CHLORIDE ION, Chalcone isomerase, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2022-10-02
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
1A6I
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BU of 1a6i by Molmil
TET REPRESSOR, CLASS D VARIANT
Descriptor: TETRACYCLINE REPRESSOR PROTEIN CLASS D
Authors:Orth, P, Cordes, F, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W.
Deposit date:1998-02-25
Release date:1999-03-02
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes of the Tet repressor induced by tetracycline trapping.
J.Mol.Biol., 279, 1998
1BJZ
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BU of 1bjz by Molmil
TETRACYCLINE CHELATED MG2+-ION INITIATES HELIX UNWINDING FOR TET REPRESSOR INDUCTION
Descriptor: TETRACYCLINE REPRESSOR
Authors:Orth, P, Saenger, W, Hinrichs, W.
Deposit date:1998-06-29
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction.
Biochemistry, 38, 1999
1ORK
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BU of 1ork by Molmil
TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE
Descriptor: 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
Authors:Orth, P, Schnappinger, D, Sum, P.-E, Ellestad, G.A, Hillen, W, Saenger, W, Hinrichs, W.
Deposit date:1998-05-21
Release date:1999-06-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
J.Mol.Biol., 285, 1999
7Z3U
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BU of 7z3u by Molmil
Crystal structure of SARS-CoV-2 Main Protease after incubation with Sulfo-Calpeptin
Descriptor: 3C-like proteinase nsp5, CHLORIDE ION, Calpeptin, ...
Authors:Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
Deposit date:2022-03-02
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
7Z3T
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BU of 7z3t by Molmil
Crystal structure of apo human Cathepsin L
Descriptor: 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ...
Authors:Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
Deposit date:2022-03-02
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
7Z58
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BU of 7z58 by Molmil
Crystal structure of human Cathepsin L in complex with covalently bound Calpeptin
Descriptor: 1,2-ETHANEDIOL, Calpeptin, Cathepsin L, ...
Authors:Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
Deposit date:2022-03-08
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
3PRK
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BU of 3prk by Molmil
INHIBITION OF PROTEINASE K BY METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE. AN X-RAY STUDY AT 2.2-ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE, PROTEINASE K
Authors:Wolf, W.M, Bajorath, J, Mueller, A, Raghunathan, S, Singh, T.P, Hinrichs, W, Saenger, W.
Deposit date:1991-08-07
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibition of proteinase K by methoxysuccinyl-Ala-Ala-Pro-Ala-chloromethyl ketone. An x-ray study at 2.2-A resolution.
J.Biol.Chem., 266, 1991
4UUG
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BU of 4uug by Molmil
The (R)-selective amine transaminase from Aspergillus fumigatus with inhibitor bound
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[O-PHOSPHONOPYRIDOXYL]--AMINO-BENZOIC ACID, ...
Authors:Thomsen, M, Hinrichs, W.
Deposit date:2014-07-28
Release date:2014-11-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Biochemical Characterization of the Dual Substrate Recognition of the (R)-Selective Amine Transaminase from Aspergillus Fumigatus
FEBS J., 282, 2015

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