Author results

5MRU
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TETR(CLASS A) IN COMPLEX WITH 5A,6-ANHYDROTETRACYCLINE AND MAGNESIUM
Descriptor:Tetracycline Repressor, class A, 5A,6-ANHYDROTETRACYCLINE, ...
Authors:Hinrichs, W., Palm, G.J.
Deposit date:2016-12-26
Release date:2018-01-17
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
To Be Published
6FPL
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TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
Descriptor:Tetracycline repressor protein class D, TETRACYCLINE, MAGNESIUM ION, ...
Authors:Hinrichs, W., Palm, G.J., Berndt, L., Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
To be published
2TRT
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TETRACYCLINE REPRESSOR CLASS D
Descriptor:TETRACYCLINE REPRESSOR CLASS D, MAGNESIUM ION, TETRACYCLINE
Authors:Hinrichs, W., Kisker, C., Saenger, W.
Deposit date:1994-03-04
Release date:1996-06-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
2TCT
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THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
Descriptor:TETRACYCLINE REPRESSOR, MAGNESIUM ION, 7-CHLOROTETRACYCLINE
Authors:Hinrichs, W., Kisker, C., Saenger, W.
Deposit date:1995-03-02
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
J.Mol.Biol., 247, 1995
2XB5
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TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, 7-IODOTETRACYCLINE, MAGNESIUM ION, ...
Authors:Kisker, C., Saenger, W., Hinrichs, W.
Deposit date:2010-04-05
Release date:2010-10-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tet Repressor-Tetracycline Complex and Regulation of Antibiotic Resistance.
Science, 264, 1994
2XRL
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TET-REPRESSOR CLASS D T103A WITH DOXYCYCLINE
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, CHLORIDE ION, (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, ...
Authors:Palm, G.J., Waack, P., Hinrichs, W.
Deposit date:2010-09-16
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:T103A Mutant of Tetrd with Doxycycline
To be Published
6FPM
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TETR(D) T103A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
Descriptor:Tetracycline repressor protein class D, TETRACYCLINE, MAGNESIUM ION, ...
Authors:Hinrichs, W., Palm, G.J., Berndt, L., Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Modular organisation of inducer recognition and allostery in the tetracycline repressor.
FEBS J., 283, 2016
6FTS
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TETR(D) N82A MUTANT IN COMPLEX WITH PEG4
Descriptor:Tetracycline repressor protein class D, TETRAETHYLENE GLYCOL, CHLORIDE ION
Authors:Hinrichs, W., Palm, G.J., Berndt, L., Girbardt, B.
Deposit date:2018-02-23
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Modular organisation of inducer recognition and allostery in the tetracycline repressor.
FEBS J., 283, 2016
1ORK
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TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE
Descriptor:TETRACYCLINE REPRESSOR, MAGNESIUM ION, 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE
Authors:Orth, P., Schnappinger, D., Sum, P.-E., Ellestad, G.A., Hillen, W., Saenger, W., Hinrichs, W.
Deposit date:1998-05-21
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
J.Mol.Biol., 285, 1999
1A6I
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TET REPRESSOR, CLASS D VARIANT
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D
Authors:Orth, P., Cordes, F., Schnappinger, D., Hillen, W., Saenger, W., Hinrichs, W.
Deposit date:1998-02-25
Release date:1999-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes of the Tet repressor induced by tetracycline trapping.
J.Mol.Biol., 279, 1998
2VPR
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TET REPRESSOR CLASS H IN COMPLEX WITH 5A,6- ANHYDROTETRACYCLINE-MG
Descriptor:TETRACYCLINE RESISTANCE REPRESSOR PROTEIN, 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, ...
Authors:Schuldt, L., Palm, G., Hinrichs, W.
Deposit date:2008-03-03
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Tet Repressor Induction by Tetracycline: A Molecular Dynamics, Continuum Electrostatics, and Crystallographic Study
J.Mol.Biol., 378, 2008
1BJZ
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TETRACYCLINE CHELATED MG2+-ION INITIATES HELIX UNWINDING FOR TET REPRESSOR INDUCTION
Descriptor:TETRACYCLINE REPRESSOR
Authors:Orth, P., Saenger, W., Hinrichs, W.
Deposit date:1998-06-29
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction.
Biochemistry, 38, 1999
2FJ1
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CRYSTAL STRUCTURE ANALYSIS OF TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-CHLORTETRACYCLINE-NICKEL(II)
Descriptor:Tetracycline repressor protein class D, NICKEL (II) ION, CHLORIDE ION, ...
Authors:Orth, P., Saenger, W., Palm, G.J., Hinrichs, W.
Deposit date:2005-12-30
Release date:2007-01-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.
J.Biol.Inorg.Chem., 13, 2008
2PKC
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CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION
Descriptor:PROTEINASE K, SODIUM ION
Authors:Mueller, A., Hinrichs, W., Wolf, W.M., Saenger, W.
Deposit date:1993-06-04
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of calcium-free proteinase K at 1.5-A resolution.
J.Biol.Chem., 269, 1994
4AUX
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TET REPRESSOR CLASS D IN COMPLEX WITH 9-NITROTETRACYCLINE
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, MAGNESIUM ION, ...
Authors:Orth, P., Saenger, W., Hinrichs, W.
Deposit date:2012-05-22
Release date:2012-05-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Tet Repressor Class D in Complex with 9-Nitrotetracycline and Magnesium
To be Published
2JCG
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APO FORM OF THE CATABOLITE CONTROL PROTEIN A (CCPA) FROM BACILLUS MEGATERIUM, WITH THE DNA BINDING DOMAIN
Descriptor:GLUCOSE-RESISTANCE AMYLASE REGULATOR, CALCIUM ION
Authors:Singh, R.K., Panjikar, S., Palm, G.J., Hinrichs, W.
Deposit date:2006-12-22
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Apo Form of the Catabolite Control Protein a (Ccpa) from Bacillus Megaterium with a DNA-Binding Domain.
Acta Crystallogr.,Sect.F, 63, 2007
2X9D
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TET REPRESSOR (CLASS D) IN COMPLEX WITH ISO-7-CHLORTETRACYCLINE
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, ISO-7-CHLORTETRACYCLINE, CHLORIDE ION
Authors:Volkers, G., Hinrichs, W.
Deposit date:2010-03-15
Release date:2011-03-23
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor.
J.Med.Chem., 54, 2011
2XPU
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TETR(D) IN COMPLEX WITH ANHYDROTETRACYCLINE.
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, 5A,6-ANHYDROTETRACYCLINE, CHLORIDE ION, ...
Authors:Dalm, D., Palm, G.J., Hinrichs, W.
Deposit date:2010-08-30
Release date:2011-09-07
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Tetracycline Repressor Allostery Does not Depend on Divalent Metal Recognition.
Biochemistry, 53, 2014
2XPV
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TETR(D) IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM.
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, MAGNESIUM ION, ...
Authors:Dalm, D., Proft, J., Palm, G.J., Hinrichs, W.
Deposit date:2010-08-30
Release date:2011-09-07
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Tetr(D) in Complex with Minocycline.
To be Published
2XPW
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TETR(D) IN COMPLEX WITH OXYTETRACYCLINE AND MAGNESIUM.
Descriptor:TETRACYCLINE REPRESSOR PROTEIN CLASS D, OXYTETRACYCLINE, MAGNESIUM ION, ...
Authors:Dalm, D., Proft, J., Palm, G.J., Hinrichs, W.
Deposit date:2010-08-30
Release date:2011-09-07
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Tetr(D) in Complex with Oxytetracycline.
To be Published
2X3A
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ASAP1 INACTIVE MUTANT E294Q, AN EXTRACELLULAR TOXIC ZINC METALLOENDOPEPTIDASE
Descriptor:TOXIC EXTRACELLULAR ENDOPEPTIDASE, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Bogdanovic, X., Palm, G.J., Singh, R.K., Hinrichs, W.
Deposit date:2010-01-22
Release date:2011-02-02
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Evidence of Intramolecular Propeptide Inhibition of the Aspzincin Metalloendopeptidase Asap1.
FEBS Lett., 590, 2016
2X3B
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ASAP1 INACTIVE MUTANT E294A, AN EXTRACELLULAR TOXIC ZINC METALLOENDOPEPTIDASE
Descriptor:TOXIC EXTRACELLULAR ENDOPEPTIDASE, ZINC ION
Authors:Bogdanovic, X., Palm, G.J., Singh, R.K., Hinrichs, W.
Deposit date:2010-01-22
Release date:2011-02-02
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Evidence of Intramolecular Propeptide Inhibition of the Aspzincin Metalloendopeptidase Asap1.
FEBS Lett., 590, 2016
2X3C
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ASAP1 INACTIVE MUTANT E294Q, AN EXTRACELLULAR TOXIC ZINC METALLOENDOPEPTIDASE
Descriptor:TOXIC EXTRACELLULAR ENDOPEPTIDASE, ZINC ION, CHLORIDE ION, ...
Authors:Bogdanovic, X., Palm, G.J., Singh, R.K., Hinrichs, W.
Deposit date:2010-01-22
Release date:2011-02-02
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Evidence of Intramolecular Propeptide Inhibition of the Aspzincin Metalloendopeptidase Asap1.
FEBS Lett., 590, 2016
2XDO
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STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX2 FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:TETX2 PROTEIN, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Volkers, G., Palm, G.J., Wright, G.D., Hinrichs, W.
Deposit date:2010-05-05
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
FEBS Lett., 585, 2011
2XT0
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DEHALOGENASE DPPA FROM PLESIOCYSTIS PACIFICA SIR-I
Descriptor:HALOALKANE DEHALOGENASE, SULFATE ION
Authors:Bogdanovic, X., Palm, G.J., Hinrichs, W.
Deposit date:2010-10-02
Release date:2011-08-10
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cloning, Functional Expression, Biochemical Characterization, and Structural Analysis of a Haloalkane Dehalogenase from Plesiocystis Pacifica Sir-1.
Appl.Microbiol.Biotechnol., 91, 2011