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4B1F
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DESIGN OF INHIBITORS OF HELICOBACTER PYLORI GLUTAMATE RACEMASE AS SELECTIVE ANTIBACTERIAL AGENTS: INCORPORATION OF IMIDAZOLES ONTO A CORE PYRAZOLOPYRIMIDINEDIONE SCAFFOLD TO IMPROVE BIOAVAILABILTY
Descriptor:GLUTAMATE RACEMASE, 5-methyl-3-(1-methyl-1H-imidazol-5-yl)-7-(2-methylpropyl)-2-(naphthalen-1-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione, D-GLUTAMIC ACID
Authors:Basarab, G.S., Hill, P., Eyermann, C.J., Gowravaram, M., Kack, H., Osimoni, E.
Deposit date:2012-07-10
Release date:2012-07-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design of Inhibitors of Helicobacter Pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles Onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty.
Bioorg.Med.Chem.Lett., 22, 2012
4MCB
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H.INFLUENZAE TRMD IN COMPLEX WITH N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, GLYCEROL, SULFATE ION, ...
Authors:Olivier, N.B., Hill, P.
Deposit date:2013-08-21
Release date:2013-09-04
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem., 56, 2013
4MCC
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HINTRMD IN COMPLEX WITH N-[4-(AMINOMETHYL)BENZYL]-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Olivier, N.B., Hill, P.
Deposit date:2013-08-21
Release date:2013-09-04
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem., 56, 2013
4J3D
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PSEUDOMONAS AERUGINOSA LPXC IN COMPLEX WITH A HYDROXAMATE INHIBITOR
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide
Authors:Lahiri, S.
Deposit date:2013-02-05
Release date:2013-04-03
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the UDP pocket of LpxC through amino acid analogs.
Bioorg.Med.Chem.Lett., 23, 2013
2W4I
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI GLUTAMATE RACEMASE IN COMPLEX WITH D-GLUTAMATE AND AN INHIBITOR
Descriptor:GLUTAMATE RACEMASE, D-GLUTAMIC ACID, 1-[(3S)-5-PHENYL-3-THIOPHEN-2-YL-3H-1,4-BENZODIAZEPIN-2-YL]AZETIDIN-3-OL
Authors:Lundqvist, T.
Deposit date:2008-11-25
Release date:2008-12-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.
Bioorg. Med. Chem. Lett., 19, 2009
3TTZ
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CRYSTAL STRUCTURE OF A TOPOISOMERASE ATPASE INHIBITOR
Descriptor:DNA gyrase subunit B, 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl]-1,3-thiazole-5-carboxylic acid, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Read, J., Eakin, A.E., Sherer, B.A.
Deposit date:2011-09-15
Release date:2011-11-16
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy.
Bioorg.Med.Chem.Lett., 21, 2011