Author results

1EXM
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS ELONGATION FACTOR TU (EF-TU) IN COMPLEX WITH THE GTP ANALOGUE GPPNHP.
Descriptor:ELONGATION FACTOR TU (EF-TU), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Hogg, T., Mesters, J.R., Hilgenfeld, R.
Deposit date:2000-05-03
Release date:2000-06-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the GTPase Mechanism of EF-Tu from Structural Studies
The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, 28, 2000
5IDK
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CRYSTAL STRUCTURE OF WEST NILE VIRUS NS2B-NS3 PROTEASE IN COMPLEX WITH A CAPPED DIPEPTIDE BORONATE INHIBITOR
Descriptor:Genome polyprotein,SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3, ((R)-1-((S)-3-(4-(aminomethyl)phenyl)-2-benzamidopropaneamido)-4-guanidinobutyl)boronic acid, ...
Authors:Hilgenfeld, R., Zhang, L.
Deposit date:2016-02-24
Release date:2016-12-14
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.
J. Med. Chem., 60, 2017
1HA3
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ELONGATION FACTOR TU IN COMPLEX WITH AURODOX
Descriptor:ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vogeley, L., Palm, G.J., Mesters, J.R., Hilgenfeld, R.
Deposit date:2001-03-26
Release date:2001-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational Change of Elongation Factor TU Induced by Antibiotic Binding: Crystal Structure of the Complex between EF-TU:Gdp and Aurodox
J.Biol.Chem., 276, 2001
1LK9
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THE THREE-DIMENSIONAL STRUCTURE OF ALLIINASE FROM GARLIC
Descriptor:ALLIIN LYASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Kuettner, E.B., Hilgenfeld, R., Weiss, M.S.
Deposit date:2002-04-24
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The active principle of garlic at atomic resolution
J.Biol.Chem., 277, 2002
1F13
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RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII
Descriptor:CELLULAR COAGULATION FACTOR XIII ZYMOGEN
Authors:Weiss, M.S., Hilgenfeld, R.
Deposit date:1998-01-16
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two non-proline cis peptide bonds may be important for factor XIII function.
FEBS Lett., 423, 1998
1VIJ
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM
Descriptor:HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE
Authors:Lange-Savage, G., Berchtold, H., Liesum, A., Hilgenfeld, R.
Deposit date:1997-05-07
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.
Eur.J.Biochem., 248, 1997
1VIK
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM
Descriptor:HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE
Authors:Lange-Savage, G., Berchtold, H., Liesum, A., Hilgenfeld, R.
Deposit date:1997-05-07
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.
Eur.J.Biochem., 248, 1997
2CIJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND METHIONINE
Descriptor:GLUTAMATE CARBOXYPEPTIDASE II, METHIONINE, ZINC ION, ...
Authors:Barinka, C., Plechanovova, A., Rulisek, L., Mlcochova, P., Majer, P., Slusher, B.S., Hilgenfeld, R., Mesters, J.R., Konvalinka, J.
Deposit date:2006-03-21
Release date:2007-03-27
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Glutamate Carboxypeptidase II
Handbook of Metalloproteins, 4, 2011
2JBJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)
Descriptor:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Henning, K., Hilgenfeld, R.
Deposit date:2006-12-07
Release date:2006-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2JBK
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH QUISQUALIC ACID (QUISQUALATE, ALPHA-AMINO-3,5-DIOXO-1,2,4- OXADIAZOLIDINE-2-PROPANOIC ACID)
Descriptor:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Henning, K., Hilgenfeld, R.
Deposit date:2006-12-07
Release date:2006-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2Q8W
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CRYSTAL STRUCTURE OF PAP-S1ACI, A POKEWEED ANTIVIRAL PROTEIN FROM SEEDS OF PHYTOLACCA ACINOSA
Descriptor:POKEWEED ANTIVIRAL PROTEIN, N-ACETYL-D-GLUCOSAMINE
Authors:Hogg, T., Hilgenfeld, R.
Deposit date:2007-06-12
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The complete covalent structure and 1.7 A crystal structure of PAP-S1aci reveals a RIP glycoprotein with multiple Asn-GlcNAc modifications
To be Published
2XCI
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, SUBSTRATE-FREE FORM
Descriptor:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, TETRAETHYLENE GLYCOL, GLYCEROL, ...
Authors:Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
Deposit date:2010-04-26
Release date:2011-05-11
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2XCU
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, COMPLEX WITH CMP
Descriptor:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ...
Authors:Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
Deposit date:2010-04-26
Release date:2011-05-11
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2J97
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 (NSP9)
Descriptor:REPLICASE POLYPROTEIN 1AB, (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION
Authors:Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
Deposit date:2006-11-03
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2J98
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 CYS69ALA MUTANT (NSP9)
Descriptor:REPLICASE POLYPROTEIN 1AB, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
Deposit date:2006-11-03
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2VB0
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 PROTEINASE 3C
Descriptor:POLYPROTEIN 3BCD, CHLORIDE ION
Authors:Anand, K., Mesters, J.R., Goerlach, R., Zell, R., Hilgenfeld, R.
Deposit date:2007-09-05
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Coxsackie Virus B3 Proteinase 3C
To be Published
1JFX
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CRYSTAL STRUCTURE OF THE BACTERIAL LYSOZYME FROM STREPTOMYCES COELICOLOR AT 1.65 A RESOLUTION
Descriptor:1,4-beta-N-Acetylmuramidase M1, CHLORIDE ION
Authors:Rau, A., Hogg, T., Marquardt, R., Hilgenfeld, R.
Deposit date:2001-06-22
Release date:2001-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A new lysozyme fold. Crystal structure of the muramidase from Streptomyces coelicolor at 1.65 A resolution.
J.Biol.Chem., 276, 2001
2VRI
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STRUCTURE OF THE NSP3 X-DOMAIN OF HUMAN CORONAVIRUS NL63
Descriptor:NON-STRUCTURAL PROTEIN 3, 1,2-ETHANEDIOL
Authors:Piotrowski, Y., Mesters, J.R., Moll, R., Hilgenfeld, R.
Deposit date:2008-04-08
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Nsp3 X-Domain of Human Coronavirus Nl63
To be Published
3O5Z
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM P85BETA SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE (PI3K)
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit beta, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Chen, S., Xiao, Y., Ponnusamy, R., Tan, J., Lei, J., Hilgenfeld, R.
Deposit date:2010-07-28
Release date:2011-08-10
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit
Acta Crystallogr.,Sect.F, 67, 2011
3P31
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CRYSTAL STRUCTURE OF THE NS1 EFFECTOR DOMAIN FROM INFLUENZA A/VIETNAM/1203/2004 (H5N1) VIRUS
Descriptor:Nonstructural protein 1, THIOCYANATE ION
Authors:Chen, S., Xiao, Y.B., Ponnusamy, R., Hilgenfeld, R.
Deposit date:2010-10-04
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published
3PV2
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (WT)
Descriptor:DegQ
Authors:Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
Deposit date:2010-12-06
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV3
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (S193A VARIANT)
Descriptor:DegQ, Substrate peptide (Poly-Ala)
Authors:Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
Deposit date:2010-12-06
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV4
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (DELTA-PDZ2 VARIANT)
Descriptor:DegQ, CADMIUM ION
Authors:Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
Deposit date:2010-12-06
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV5
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (N189G/P190G VARIANT)
Descriptor:DegQ
Authors:Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
Deposit date:2010-12-06
Release date:2011-06-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
4YNN
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STRUCTURE OF LEGIONELLA PNEUMOPHILA DEGQ (S190A VARIANT)
Descriptor:Protease DO, Octapeptide, Hexa-peptide, ...
Authors:Wrase, R., Hilgenfeld, R., Hansen, G.
Deposit date:2015-03-10
Release date:2015-06-24
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of DegQ from Legionella pneumophila Define Distinct ON and OFF States.
J.Mol.Biol., 427, 2015